Results 61 to 70 of about 46,932 (244)

Advancing Maternal Health with Long‐Acting Therapeutics: Priorities, Efficacy and Safety Considerations, and Emerging Technologies

Clinical Pharmacology &Therapeutics, EarlyView.
Maternal health remains a critical global concern, particularly in underserved populations and in low‐ and middle‐income countries where access to safe and effective therapeutics is limited. Despite the use of medications by most women during pregnancy, the exclusion of pregnant and lactating women from clinical trials has resulted in significant data ...
Rachel K. Scott, Sharon Nachman, Ethel D. Weld, Rachel Daley, Shakir Atoyebi, Robert Bies, Catriona Waitt, Adeniyi Olagunju   +7 more
wiley   +1 more source

A longitudinal cohort study on dispensed analgesic and psychotropic medications in older adults before, during, and after the COVID-19 pandemic: the HUNT study

BMC Geriatrics
Background There is a growing concern and debate over the inappropriate use of analgesics and psychotropic medications by older adults, especially those with dementia.
Tanja Louise Ibsen, Ekaterina Zotcheva, Sverre Bergh, Debby Gerritsen, Gill Livingston, Hilde Lurås, Svenn-Erik Mamelund, Anne Marie Mork Rokstad, Bjørn Heine Strand, Richard C. Oude Voshaar, Geir Selbæk   +10 more
doaj   +1 more source

Unveiling Hepatic Protein Alterations in Neonatal and Infant Biliary Atresia

Clinical Pharmacology &Therapeutics, EarlyView.
Pediatric populations differ from adults in drug elimination capacity. While current scaling methods account for enzyme and transporter maturation, they overlook comorbidities, such as biliary atresia (BA), a liver disease appearing within the first 2–8 weeks of life that can progress to cirrhosis.
Zubida M. Al‐Majdoub, Martyn Howard, Brahim Achour, Jill Barber, Naved Alizai, Amin Rostami‐Hodjegan   +5 more
wiley   +1 more source

Patient‐ and Clinician‐Related Factors Associated With the Reduction in Opioid Use Among Adults With Chronic Non‐Cancer Pain: A Systematic Review

Clinical Pharmacology &Therapeutics, EarlyView.
Despite known risks, opioids are widely used for chronic non‐cancer pain (CNCP). Clinical guidelines now recommend deprescribing, but factors predicting success are poorly understood. This systematic review aimed to identify clinician and patient factors associated with attaining successful opioid dose reduction or discontinuation in adults with CNCP ...
Alessandra C. Marcelo, Sarah N. Hilmer, David J. Hunter, Stephanie Mathieson, Riyaas Mohamed, Leo Li, Natalie Fung, Anthony Yue, Manuela L. Ferreira   +8 more
wiley   +1 more source

Obtainment of prescribed analgesics among patients with Lyme neuroborreliosis; a nationwide, population-based matched cohort study

Ticks and Tick-Borne Diseases
Background: Radicular pain is the most predominant symptom among adults with Lyme neuroborreliosis (LNB) but the duration preceding and following diagnosis remains unknown.
Malte M. Tetens, Nanna S. Andersen, Ram B. Dessau, Svend Ellermann-Eriksen, Charlotte Sværke Jørgensen, Michael Pedersen, Jacob Bodilsen, Kirstine K. Søgaard, Jette Bangsborg, Alex Christian Yde Nielsen, Jens Kjølseth Møller, Niels Obel, Anne-Mette Lebech, Lars Haukali Omland   +13 more
doaj   +1 more source

Evaluation of Therapeutic Opioids in Skin‐Derived Matrices (Sweat and Sebum) of Neonatal and Pediatric Patients and Their Role in Opioid Incorporation Into Hair

Drug Testing and Analysis, EarlyView.
Concentration ranges, dose–concentration relationships, and metabolite‐to‐parent drug ratios of therapeutic opioids were evaluated in hair and skin swab samples of 150 pediatric patients. Skin‐derived matrices such as sweat or sebum were shown to contribute to analyte incorporation into hair in a systematic manner.
Max Polke, Florian Zapf, Julia T. Scherer, Clarissa D. Voegel, Tanja Restin, Marc W. Schmid, Thomas Kraemer, Tina M. Binz   +7 more
wiley   +1 more source

Overuse of the psychoactive analgesics' opioids and gabapentinoid drugs in patients having surgery for nerve entrapment disorders. [PDF]

Sci Rep, 2023
Dahlin LB, Perez R, Nyman E, Zimmerman M, Merlo J.   +4 more
europepmc   +1 more source

The Depth‐Specific Effects of Acupuncture for Post‐Stroke Gastroparesis: Protocol for a Randomized Controlled Trial of Deep Versus Superficial Needling

Gut Medicine, EarlyView.
ABSTRACT Background Post‐stroke gastroparesis (GP) is a debilitating complication that severely impairs quality of life. Although abdominal acupuncture is widely used, robust evidence regarding its efficacy, particularly concerning the critical parameter of the needling depth, is still lacking.
Xiangcheng Wei, Can Wang, Yuan Qin, Lanping Li, Shiqing Zhao, Yee Hwee Cheong, Yang Guo, Lingyong Xiao, Xiaoyu Dai   +8 more
wiley   +1 more source

Use of analgesics before and after total joint replacement in working-age Japanese patients with knee and hip osteoarthritis: A retrospective database study

Asia-Pacific Journal of Sports Medicine, Arthroscopy, Rehabilitation and Technology
Background: Patterns of analgesic use before and after total joint replacement (TJR) in patients with knee/hip osteoarthritis (OA) is not well reported.
Nozomi Ebata, Takashi Sakai, Hiroyuki Yamamoto, Tetsumi Toyoda, Kanae Togo, Masataka Deie   +5 more
doaj   +1 more source

Spotlight commentary: Deprescribing in long‐term care facilities—Towards safer and smarter medication use in older adults

British Journal of Clinical Pharmacology, EarlyView.
Nataša Skočibušić, Igor Rubinić, Vera Vlahović‐Palčevski   +2 more
wiley   +1 more source