Results 31 to 40 of about 247,850 (306)

Trends and characteristics of accidental and intentional codeine overdose deaths in Australia [PDF]

, 2015
Examines trends in codeine-related mortality rates in Australia, and the clinical and toxicological characteristics of codeine-related deaths. Abstract Objectives: To examine trends in codeine-related mortality rates in Australia, and the clinical and ...
Amanda Roxburgh, Eva Saar, Jennifer Pilgrim, Louisa Degenhardt, Lucinda Burns, Suzanne Nielsen, Wayne D Hall   +6 more
core   +1 more source

Opioid Analgesics [PDF]

Mayo Clinic Proceedings, 2015
Chronic pain is an international health issue of immense importance that is influenced by both physical and psychological factors. Opioids are useful in treating chronic pain but have accompanying complications. It is important for clinicians to understand the basics of opioid pharmacology, the benefits and adverse effects of opioids, and related ...
Robert N, Jamison, Jianren, Mao
openaire   +2 more sources

Spray-Dried Celtis iguanaea (Jacq.) Planch (Cannabaceae) Extract: Building Evidence for Its Therapeutic Potential in Pain and Inflammation Management

Plants
Celtis iguanaea, widely used in Brazilian folk medicine, is known for its analgesic and anti-inflammatory properties. This study evaluated the in vitro antioxidant capacity and the in vivo antinociceptive and anti-inflammatory mechanisms of the ...
Kátia Regina Ribeiro, Rúbia Bellard e Silva, João Paulo Costa Rodrigues, Mairon César Coimbra, Laura Jéssica Pereira, Emmilly de Oliveira Alves, Flávio Martins de Oliveira, Marx Osório Araújo Pereira, Eric de Souza Gil, Carlos Alexandre Carollo, Nadla Soares Cassemiro, Camile Aparecida da Silva, Pablinny Moreira Galdino de Carvalho, Flávia Carmo Horta Pinto, Renan Diniz Ferreira, Zakariyya Muhammad Bello, Edilene Santos Alves de Melo, Marina Andrade Rocha, Ana Gabriela Silva, Rosy Iara Maciel Azambuja Ribeiro, Adriana Cristina Soares, Renê Oliveira do Couto   +21 more
doaj   +1 more source

Analgesic and anti-inflammatory effects of hydroalcoholic and hexane extracts of Smyrniopsis aucheri in animal models

International Journal of Preventive Medicine, 2021
Background: The fruits of Apiaceae family have been widely used in traditional medicine for the treatment of pain and inflammation. In this study, we evaluated the analgesic and anti-inflammatory effects of wild celery (Smyrniopsis aucheri) seeds, as a ...
Valiollah Hajhashemi, Seyed Ebrahim Sajjadi, Maram Hasani   +2 more
doaj   +1 more source

Development of a Novel Method of Spinal Electrophysiological Assessment via Intrathecal Administration at Analgesic Doses

Neurology International
Background/Objectives: Chronic pain is a significant global health challenge and is associated with diverse conditions, such as diabetic neuropathic pain and spinal stenosis.
Daisuke Uta, Takuya Yamane, Sosuke Yoneda, Erika Kasai, Toshiaki Kume   +4 more
doaj   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Prescribed medication for postoperative endodontic pain management by dentists in Taif, Saudi Arabia

Saudi Journal of Oral Sciences
Introduction: Endodontic treatment may require the prescription of analgesics. Current research is unclear regarding their use, especially after root canal therapy. Dentists over-prescribing them can negatively affect the patient’s health and well-being.
Faisal K. Altalhi, Hassan T. Shawli, Ayman Mandorah, Bandar S. Shukr, Sami Dakhil Allah Alharthi, Ghada A. Althobiti, Saif K. Alzahrani   +6 more
doaj   +1 more source

Continuous quadratus lumborum block as post-operative strategy for pain control in spinal fusion surgery

Indian Journal of Anaesthesia, 2020
Background and Aims: Lumbar spinal fusions have post-operative pain levels that can be difficult to treat. The objective of this study was to determine if using bilateral quadratus lumborum (QL) nerve block catheters for lumbar fusions changes the ...
Jon Wilton, Helen Chiu, Natalie Codianne, Herschel Knapp, Vicente Roques Escolar, Shari Burns   +5 more
doaj   +1 more source

Quantitative sensory testing in painful hand osteoarthritis demonstrates features of peripheral sensitisation. [PDF]

, 2012
Hand osteoarthritis (HOA) is a prevalent condition for which treatments are based on analgesia and physical therapies. Our primary objective was to evaluate pain perception in participants with HOA by assessing the characteristics of nodal involvement ...
Ejindu, V, Hermansson, M, Heron, C, Kiely, P, Sofat, N, Wajed, J   +5 more
core   +2 more sources

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source