Results 41 to 50 of about 41,207 (254)

Discovery of 7-Azanorbornane-Based Dual Agonists for the Delta and Kappa Opioid Receptors through an In Situ Screening Protocol

Molecules, 2023
In medicinal chemistry, the copper-catalyzed click reaction is used to prepare ligand candidates. This reaction is so clean that the bioactivities of the products can be determined without purification.
Fumika Karaki, Taro Takamori, Koumei Kawakami, Sae Sakurai, Kyoko Hidaka, Kei Ishii, Tomoya Oki, Noriko Sato, Nao Atsumi, Karin Ashizawa, Ai Taguchi, Asuka Ura, Toko Naruse, Shigeto Hirayama, Miki Nonaka, Kanako Miyano, Yasuhito Uezono, Hideaki Fujii   +17 more
doaj   +1 more source

A Return to Normality: A Descriptive Qualitative Interview Study Exploring the Patient Experience of Gout Flare Resolution

Arthritis Care &Research, EarlyView.
Objective Although the definition of a gout flare is well established, the state of gout flare resolution has not yet been defined. This study aimed to explore patients’ experiences and perceptions of gout flare resolution. Methods Semistructured interviews were conducted with 24 people with gout, guided by open‐ended questions exploring their ...
Sarah Stewart, Anne Horne, Angelo Gaffo, Lisa K. Stamp, N. Lawrence Edwards, Nicola Dalbeth   +5 more
wiley   +1 more source

Risk Factors for Respiratory Depression Associated with Tramadol Based on the Global Pharmacovigilance Database (VigiBase)

Pharmaceuticals
Tramadol, a weak μ-opioid receptor agonist, has been used worldwide for pain management. It is considered to have a favorable safety profile without serious adverse events; however, safety issues of respiratory depression were proposed by regulatory ...
Sunny Park, Geon-Ho Lee, Soyun Kim, Solee Kim, Yeju Kim, Soo-An Choi   +5 more
doaj   +1 more source

The Impact of Stigma on People with Opioid Use Disorder, Opioid Treatment, and Policy

Substance Abuse and Rehabilitation, 2022
Ali Cheetham,1,2 Louisa Picco,1 Anthony Barnett,1,2 Dan I Lubman,1,2 Suzanne Nielsen1,2 1Monash Addiction Research Centre, Eastern Health Clinical School, Monash University Peninsula Campus, Frankston, Victoria, 3199, Australia; 2Turning Point, Eastern ...
Cheetham A, Picco L, Barnett A, Lubman DI, Nielsen S   +4 more
doaj  

Mitochondria‐Targeted Nanotherapies in Aging Neurodegenerative Disorders: Emerging Prospects and Clinical Potential

Advanced Healthcare Materials, EarlyView.
Mitochondria‐targeted nanotherapies emerge as a promising strategy for combating aging‐associated neurodegenerative disorders (NDs) by restoring mitochondrial function, reducing oxidative stress, and improving neuronal survival. Recent advances in nanotechnology, therapeutic delivery, and translational research are highlighted, providing insights into ...
Dnyandev G. Gadhave, Ashish B. Jadhav, Nitin B. Waghamode, Shubham Khot, Rajiya Khan, Ravi Hole, Shankar M. Dhobale, Manoj Aswar, Keshav Raj Paudel   +8 more
wiley   +1 more source

Innate Immunocompetent hiPSC‐Derived Neurospheroids Capture Early CNS Responses to rAAV

Advanced Science, EarlyView.
Knowledge of human CNS immune responses to AAV‐based gene therapies remains limited due to the lack of immune‐competent human models. Here, a hiPSC‐derived 3D neuroimmune platform integrating neurospheroids and microglia is established using stirred‐tank bioreactors.
Catarina M. Gomes, Gabriela Silva, Mafalda Aleixo, Marta Gomes, Daniel Simão, Stephan J. Holtkamp, Diana D. Lobo, Pradeep Harish, Rosalind Jenkins, Lekh N. Dahal, Rui J. Nobre, Luís de Pereira de Almeida, Mark Trautwein, Paula M. Alves, Catarina Brito   +14 more
wiley   +1 more source

Forensic analysis of analgesics by TLC [PDF]

, 2011
An introductory laboratory on the identification of analgesics in an unknown sample. Ideal for the first week of an organic chemistry sequence to get students familiar with their surroundings.
Mulcahy, Seann P.
core  

Analgesics score.

, 2013
Analgesics score at 1, 2, 4, 8 and 12 weeks from the beginning of treatment. Consumption of analgesics was evaluated by the physician on the basis of the medical records using the 5-point WHO score, as follows: level 0, no analgesics required; level 1 ...
Zvi Symon (432623), Baruch Brenner (432625), Bella Kaufman (196589), Nicola J. Nasser (374364), Raphael M. Pfeffer (432621), Ofer Purim (432618), Yulia Kundel (432617), Aaron Sulkes (432624), Rinat Yerushalmi (432619), Salomon M. Stemmer (206132), Shulamith Rizel (432622), Eyal Fenig (432620)   +11 more
core   +1 more source

Narcotic Analgesics: OPIOIDS [PDF]

, 2019
Opioids are morphine-like analgesics used for the management of severe pain, such as acute pain and cancer pain. They are mostly preferred in cases of acute and chronic severe pain.
Erbaba, Hülya
core   +1 more source

Influence of fentanyl, ketamine or lidocaine infusion on the intraocular pressure and pupil size in conscious dogs

Veterinární Medicína, 2022
Fifty-five healthy conscious dogs were included in a prospective randomised double-blinded clinical study. The dogs allocated to one of four groups received intravenous bolus followed by infusion of fentanyl (FEN-group), or ketamine (KET-group), or ...
P Rauser, H Nemeckova, M Mrazova, J Vaclavikova, L Novak   +4 more
doaj   +1 more source