Results 41 to 50 of about 460,894 (401)
Molecules, 2023 In medicinal chemistry, the copper-catalyzed click reaction is used to prepare ligand candidates. This reaction is so clean that the bioactivities of the products can be determined without purification.
Fumika Karaki +17 more
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Addressing the Global Tragedy of Needless Pain: Rethinking the United Nations Single Convention on Narcotic Drugs [PDF]
, 2007 The lack of medical availability of effective pain medication is an enduring and expanding global health calamity. Despite important medical advances, pain remains severely under-treated worldwide, particularly in developing countries.
Allyn L. Taylor +11 more
core +2 more sources
Journal of the American Medical Association (JAMA), 2019 Discontinuation of Long-term Opioid Analgesics was responsible for developing the HHS Guide for Clinicians on the Appropriate Dosage Reduction or Discontinuation of Long-Term Opioid Analgesics. Deborah (US Centers for and Christopher PharmD, DrPH and MPE
D. Dowell, W. Compton, B. Giroir
semanticscholar +1 more source
British medical journal, 2015 Objective To study the association between benzodiazepine prescribing patterns including dose, type, and dosing schedule and the risk of death from drug overdose among US veterans receiving opioid analgesics. Design Case-cohort study.
Tae Woo Park +4 more
semanticscholar +1 more source
Acute pain management in the trauma patient population: are we doing enough? A prospective observational study [PDF]
Journal of Trauma and Injury, 2022 Purpose There is a strong correlation between trauma and pain. Pain increases the rate of depression, posttraumatic stress disorder, and even mortality in trauma patients.
Segni Kejela, Nebyou Seyoum
doaj +1 more source
In vitro and in vivo pharmacological activities of 14-o-phenylpropyloxymorphone, a potent mixed mu/delta/kappa-opioid receptor agonist with reduced constipation in mice [PDF]
, 2018 Pain, particularly chronic pain, is still an unsolved medical condition. Central goals in pain control are to provide analgesia of adequate efficacy and to reduce complications associated with the currently available drugs.
Lattanzi, Roberta +4 more
core +2 more sources
Reactions weekly, 2019 It is the responsibility of the professional care team to develop an effective person-centred Pain Management strategy which appropriately assesses patients, analyses the results of the assessment and devises a person centred plan to manage pain while ...
M. Botea
semanticscholar +1 more source
Veterinární Medicína, 2022 Fifty-five healthy conscious dogs were included in a prospective randomised double-blinded clinical study. The dogs allocated to one of four groups received intravenous bolus followed by infusion of fentanyl (FEN-group), or ketamine (KET-group), or ...
P Rauser +4 more
doaj +1 more source
BU10038 as a safe opioid analgesic with fewer side-effects after systemic and intrathecal administration in primates [PDF]
, 2019 © 2019 British Journal of Anaesthesia. Published by Elsevier Ltd. All rights reserved.Background: The marked increase in mis-use of prescription opioids has greatly affected our society. One potential solution is to develop improved analgesics which have
Cami-Kobeci, Gerta +9 more
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An interpretable boosting model to predict side effects of analgesics for osteoarthritis
BMC Systems Biology, 2018 BackgroundOsteoarthritis (OA) is the most common disease of arthritis. Analgesics are widely used in the treat of arthritis, which may increase the risk of cardiovascular diseases by 20% to 50% overall.There are few studies on the side effects of OA ...
Liangliang Liu +7 more
semanticscholar +1 more source