Results 41 to 50 of about 119,844 (299)

Third order digital-to-analog converter [PDF]

open access: yes, 1972
System, consisting of sample and hold digital-to-analog converter, clock circuit, sample delay circuit, initial condition circuit and interpolator circuit, improves accuracy of reconstructed analog signal without increasing sample ...
Dotson, W. P.
core   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

open access: yesMolecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto   +13 more
wiley   +1 more source

Nonlinear feedback reduces analog-to-digital converter error [PDF]

open access: yes, 1965
Nonlinear analog-to-digital converter measures the analog input level and continuously adjusts the digital readout scale sensitivity to effectively increase the accuracy.
Munoz, R. M.
core   +1 more source

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

open access: yesMolecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto   +8 more
wiley   +1 more source

Small, low power analog-to-digital converter [PDF]

open access: yes, 1968
A small, low-power, high-speed, 8-bit analog-to-digital converter using silicon chip integrated circuits is suitable for use in airborne test data systems.
Dunn, R. D., Fullerton, D. H.
core   +1 more source

A Digitally Calibrated 12 bits 25 MS/s Pipelined ADC with a 3 input multiplexer for CALICE Integrated Readout [PDF]

open access: yes, 2009
The necessity of full integrated electronics readout for the next ILC ECAL presents many challenges for low power mixed signal design. The analog to digital converter is a critical stage for the system going from the very front-end stages to digital ...
Dzahini, D   +3 more
core   +1 more source

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

open access: yesMolecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg   +43 more
wiley   +1 more source

Rate augmented digital to analog converter Patent [PDF]

open access: yes, 1971
Development and characteristics of rate augmented digital to analog converter for computed time-dependent ...
Kopelson, S.
core   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang   +12 more
wiley   +1 more source

Highly linear, sensitive analog-to-digital converter [PDF]

open access: yes, 1969
Analog-to-digital converter converts 10 volt full scale input signal into 13 bit digital output. Advantages include high sensitivity, linearity, low quantitizing error, high resistance to mechanical shock and vibration loads, and temporary data storage ...
Cox, J., Finley, W. R.
core   +1 more source

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