Results 61 to 70 of about 298,889 (339)
Molecular Oncology, EarlyView.This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris +10 more
wiley +1 more source
Digital data transition tracking loop improves data reception [PDF]
, 1970 Transition tracking loop eliminates drifts, leakages, and instabilities inherent in analog filters.
Anderson, T. O. +2 more
core +1 more source
Molecular Oncology, EarlyView.Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang +3 more
wiley +1 more source
Circuit analysis of RC integration circuits for use in PWM-based DACs
Известия Томского политехнического университета: Промышленная кибернетикаIn scientific, educational, and engineering settings, it is often necessary to transmit analog signals to control various actuators. Examples of such devices include motors, valves, dampers, lighting, and audio equipment.
Kirill A. Volobuev +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Digitized synchronous demodulator [PDF]
, 1990 A digitized synchronous demodulator is constructed entirely of digital components including timing logic, an accumulator, and means to digitally filter the digital output signal.
Woodhouse, Christopher E.
core +1 more source
Advanced analog filters for telecommunications [PDF]
Proceedings of the conference on Design, automation and test in Europe, 2008 In this paper advances on analog filter design for telecom transceivers are addressed. Portable devices require a strong power consumption reduction to increase the battery life. Since a considerable part of the power consumption is due to the analog baseband filters, improved and/or novel analog filter design approaches have to be developed.
DE MATTEIS, MARCELLO +2 more
openaire +1 more source
The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity
Molecular Oncology, EarlyView.Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli +7 more
wiley +1 more source
Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer
Molecular Oncology, EarlyView.PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta +10 more
wiley +1 more source
Novel CCII-based Field Programmable Analog Array and its Application to a Sixth-Order Butterworth LPF [PDF]
, 2013 In this paper, a field programmable analog array (FPAA) is proposed. The proposed FPAA consists of seven configurable analog blocks (CABs) arranged in a hexagonal lattice such that the CABs are directly connected to each other.
Mahmoud, S. A., Soliman, E. A.
core +1 more source