Results 61 to 70 of about 298,426 (292)
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Digital input is buffered to real-time analog display [PDF]
, 1970 Buffering technique utilizes nine-bit binary counter and holding register of eight flip-flops. These flip-flops form the memory device that allows precise asynchronous conversion of the digital source data.
Bower, K. F.
core +1 more source
, 2006 This paper studies the sensitivity of hybrid filter banks (HFB) to analog inaccuracies and finite word implementation. It is shown that very small errors affecting very simple analog structures have a dramatic influence on the performances of the HFB ...
Oksman, Jacques, Petrescu, Tudor
core +4 more sources
The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity
Molecular Oncology, EarlyView.Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli +7 more
wiley +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Molecular Oncology, EarlyView.Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley +5 more
wiley +1 more source
Circuit analysis of RC integration circuits for use in PWM-based DACs
Известия Томского политехнического университета: Промышленная кибернетикаIn scientific, educational, and engineering settings, it is often necessary to transmit analog signals to control various actuators. Examples of such devices include motors, valves, dampers, lighting, and audio equipment.
Kirill A. Volobuev +3 more
doaj +1 more source
Advanced analog filters for telecommunications [PDF]
Proceedings of the conference on Design, automation and test in Europe, 2008 In this paper advances on analog filter design for telecom transceivers are addressed. Portable devices require a strong power consumption reduction to increase the battery life. Since a considerable part of the power consumption is due to the analog baseband filters, improved and/or novel analog filter design approaches have to be developed.
DE MATTEIS, MARCELLO +2 more
openaire +1 more source
Digitized synchronous demodulator [PDF]
, 1990 A digitized synchronous demodulator is constructed entirely of digital components including timing logic, an accumulator, and means to digitally filter the digital output signal.
Woodhouse, Christopher E.
core +1 more source
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source