Results 51 to 60 of about 1,113,738 (296)

Mechanics of elastic-plastic shells

open access: yes, 1980
Issued as Annual report and Final report, Project no. E-23-649Includes two reprints from "Journal of Applied Mechanics" and "Computer Methods in Applied Mechanics and Engineering.
Wempner, Gerald
core   +1 more source

Design and analysis strategies for robust microbiome ageing research

open access: yesFEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik   +5 more
wiley   +1 more source

Reconstructing enzyme evolution by protein engineering

open access: yesFEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler   +2 more
wiley   +1 more source

Entanglement Exchange and Bohmian Mechanics [PDF]

open access: yes, 2009
This paper analyses the phenomenon of entanglement exchange in Bohm's pilot wave interpretation of quantum mechanics. The interesting feature of the phenomenon is that systems become entangled without causal interaction; hence it is a useful situation ...
Vistarini, Tiziana, Huggett, Nick
core  

The X-Mechanics toolbox to solve Y-Mechanics problems [PDF]

open access: yes, 2017
The philosophy of "X-Mechanics" is introduced, and a few examples of its application by the author and collaborators to study "Y-Mechanics" problems are presented ...
Curtin, W. A., W.A. Curtin
core   +2 more sources

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

open access: yesFEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang   +4 more
wiley   +1 more source

Analytic invariants associated with a parabolic fixed point in C2 [PDF]

open access: yes, 2008
It is well known that in a small neighbourhood of a parabolic fixed point a real-analytic diffeomorphism of (R2,0) embeds in a smooth autonomous flow.
Naudot, V., Gelfreich, Vassili
core   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

open access: yesFEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta   +3 more
wiley   +1 more source

Structure‐forward targeting of claudins with synthetic binders

open access: yesFEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Proceedings of the Fifth Canadian Soil Mechanics Conference, January 10 and 11, 1952

open access: yes, 1952
This is the record of a Conference of most of the active Canadian workers in the field of soil mechanics, held in the Seminar Room of the Montreal Road Laboratories of the National Research Councilor Canada, in Ottawa on January 10-11, 1952, under the ...

core   +1 more source

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