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Mechanics of elastic-plastic shells
Issued as Annual report and Final report, Project no. E-23-649Includes two reprints from "Journal of Applied Mechanics" and "Computer Methods in Applied Mechanics and Engineering.
Wempner, Gerald
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Design and analysis strategies for robust microbiome ageing research
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
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Reconstructing enzyme evolution by protein engineering
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
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Entanglement Exchange and Bohmian Mechanics [PDF]
This paper analyses the phenomenon of entanglement exchange in Bohm's pilot wave interpretation of quantum mechanics. The interesting feature of the phenomenon is that systems become entangled without causal interaction; hence it is a useful situation ...
Vistarini, Tiziana, Huggett, Nick
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The X-Mechanics toolbox to solve Y-Mechanics problems [PDF]
The philosophy of "X-Mechanics" is introduced, and a few examples of its application by the author and collaborators to study "Y-Mechanics" problems are presented ...
Curtin, W. A., W.A. Curtin
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Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
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Analytic invariants associated with a parabolic fixed point in C2 [PDF]
It is well known that in a small neighbourhood of a parabolic fixed point a real-analytic diffeomorphism of (R2,0) embeds in a smooth autonomous flow.
Naudot, V., Gelfreich, Vassili
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Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
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Structure‐forward targeting of claudins with synthetic binders
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
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Proceedings of the Fifth Canadian Soil Mechanics Conference, January 10 and 11, 1952
This is the record of a Conference of most of the active Canadian workers in the field of soil mechanics, held in the Seminar Room of the Montreal Road Laboratories of the National Research Councilor Canada, in Ottawa on January 10-11, 1952, under the ...
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