Results 81 to 90 of about 515,471 (330)
A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression
Molecular Oncology, EarlyView.Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak +8 more
wiley +1 more source
Frontiers in Remote SensingIndroductionEstimating snow depth over Arctic sea ice is essential for understanding climate processes and supporting operational forecasting. Previous work has demonstrated the use of lidar backscattering pathlength moments from Ice, Cloud, and land ...
Sunny Sun-Mack +4 more
doaj +1 more source
Retrieving information from a noisy "knowledge network"
, 2007 We address the problem of retrieving information from a noisy version of the ``knowledge networks'' introduced by Maslov and Zhang. We map this problem onto a disordered statistical mechanics model, which opens the door to many analytical and numerical ...
Castellani T, J Barré, Montanari A
core +1 more source
Molecular Oncology, EarlyView.CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir +12 more
wiley +1 more source
Modeling thermo-mechanical fatigue for rolling die under continuous casting process
Results in EngineeringIn the continuous casting process, the rolling die is exposed to non-steady stress conditions that can initiate thermo-mechanical fatigue damage. Understanding the rolling die failure mechanism is essential in metal-forming industries.
Mesay Alemu Tolcha, Hirpa Gelgele Lemu
doaj +1 more source
Conditions of equivalence of effects for the solid body from incompressible material
MATEC Web of Conferences, 2018 Polemicizing with the existing opinion that modern numerical methods allow to solve practically any problem of mechanics, it should be noted that analytical and experimental methods still are relevant, and a complex of methods leads to development of ...
Agakhanov Elephan +3 more
doaj +1 more source
Analytical Elastostatic Contact Mechanics of Highly-Loaded Contacts of Varying Conformity
Lubricants, 2020 In applications requiring high load carrying capacity, conforming contacting pairs with a relatively large contact footprint are used. These include circular arc, Novikov, and Wildhaber gears found, for example, in helicopter rotors.
Patricia M. Johns-Rahnejat +2 more
doaj +1 more source
Acoustic emission from a growing crack [PDF]
An analytical method is being developed to determine the signature of an acoustic emission waveform from a growing crack and the results of this analysis are compared to experimentally obtained values.
Jacobs, Laurence J.
core +1 more source
Numerical approach to the Schrodinger equation in momentum space
, 2009 The treatment of the time-independent Schrodinger equation in real-space is an indispensable part of introductory quantum mechanics. In contrast, the Schrodinger equation in momentum space is an integral equation that is not readily amenable to an ...
Christopher R. Jamell +9 more
core +1 more source
Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA
Molecular Oncology, EarlyView.Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson +2 more
wiley +1 more source