Results 81 to 90 of about 3,397,715 (333)

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

Modeling thermo-mechanical fatigue for rolling die under continuous casting process

Results in Engineering
In the continuous casting process, the rolling die is exposed to non-steady stress conditions that can initiate thermo-mechanical fatigue damage. Understanding the rolling die failure mechanism is essential in metal-forming industries.
Mesay Alemu Tolcha, Hirpa Gelgele Lemu
doaj   +1 more source

Conditions of equivalence of effects for the solid body from incompressible material

MATEC Web of Conferences, 2018
Polemicizing with the existing opinion that modern numerical methods allow to solve practically any problem of mechanics, it should be noted that analytical and experimental methods still are relevant, and a complex of methods leads to development of ...
Agakhanov Elephan, Agakhanov Murad, Sultanova Lyudmila, Hizriyeva Zabiya   +3 more
doaj   +1 more source

Contact area of rough spheres: Large scale simulations and simple scaling laws

, 2016
We use molecular simulations to study the nonadhesive and adhesive atomic-scale contact of rough spheres with radii ranging from nanometers to micrometers over more than ten orders of magnitude in applied normal load. At the lowest loads, the interfacial
Bowden F. P., Hockney R. W., Israelachvili J. N., Lars Pastewka, Mark O. Robbins, Maugis D.   +5 more
core   +1 more source

Investigating the cell of origin and novel molecular targets in Merkel cell carcinoma: a historic misnomer

Molecular Oncology, EarlyView.
This study indicates that Merkel cell carcinoma (MCC) does not originate from Merkel cells, and identifies gene, protein & cellular expression of immune‐linked and neuroendocrine markers in primary and metastatic Merkel cell carcinoma (MCC) tumor samples, linked to Merkel cell polyomavirus (MCPyV) status, with enrichment of B‐cell and other immune cell
Richie Jeremian, Sriraam Sivachandran, Melissa Galati, Brandon Ramchatesingh, Hibo Rijal, Johnny Hanna, Elena Netchiporouk, May Chergui, Margaret Redpath, Samy Abou Setah, Ivan V. Litvinov   +10 more
wiley   +1 more source

Analytical Elastostatic Contact Mechanics of Highly-Loaded Contacts of Varying Conformity

Lubricants, 2020
In applications requiring high load carrying capacity, conforming contacting pairs with a relatively large contact footprint are used. These include circular arc, Novikov, and Wildhaber gears found, for example, in helicopter rotors.
Patricia M. Johns-Rahnejat, Nader Dolatabadi, Homer Rahnejat   +2 more
doaj   +1 more source

Analytical solution of stochastic model of risk-spreading with global coupling

, 2013
We study a stochastic matrix model to understand the mechanics of risk-spreading (or bet-hedging) by dispersion. Such model has been mostly dealt numerically except for well-mixed case, so far.
Morita, Satoru, Yoshimura, Jin
core   +1 more source

Tumor‐agnostic detection of circulating tumor DNA in patients with advanced pancreatic cancer using targeted DNA methylation sequencing and cell‐free DNA fragmentomics

Molecular Oncology, EarlyView.
We evaluated circulating tumor DNA (ctDNA) detection in advanced pancreatic cancer using DNA methylation, cell‐free DNA fragment lengths, and 5′ end motifs. Machine learning models were trained to estimate ctDNA levels from each feature and their combination.
Morten Lapin, Kjersti Tjensvoll, Karin Hestnes Edland, Satu Oltedal, Herish Garresori, Bjørnar Gilje, Saga Ekedal, Trygve Eftestøl, Jan Terje Kvaløy, Filip Janku, Oddmund Nordgård   +10 more
wiley   +1 more source

Self-Similar Crossover in Statistical Physics

, 2000
An analytical method is advanced for constructing interpolation formulae for complicated problems of statistical mechanics, in which just a few terms of asymptotic expansions are available.
Baker, Baker, Benettin, Blote, Edwards, Fisher, Girardeau, Gluzman, Irving, Lieb, Muthukumar, Muthukumar, Nakamura, Oguchi, S Gluzman, Saff, Selyugin, Simon, Takahashi, Takahashi, Theodorakopoulos, V.I Yukalov, Von Meyenn, Yukalov, Yukalov, Yukalov, Yukalov, Yukalov, Yukalov, Yukalov, Yukalov, Yukalov, Yukalov, Yukalova, Čizek   +34 more
core   +1 more source

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source