The newfound relationship between extrachromosomal DNAs and excised signal circles
FEBS Letters, EarlyView.Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
Analytical Quality by Design approach in development and optimization of HPLC method for assay of angiotensin – converting enzyme inhibitor in tablets [PDF]
Makedonsko Farmacevtski BiltenImplementation of analytical quality by design approach is a helpful tool in development of a robust analytical method which is applicable throughout the lifecycle of the product.
Veronika Popovska Jakimovska +7 more
doaj +1 more source
Towards Evaluating the Quality of a Spreadsheet: The Case of the Analytical Spreadsheet Model [PDF]
, 2011 We consider the challenge of creating guidelines to evaluate the quality of a spreadsheet model. We suggest four principles. First, state the domain-the spreadsheets to which the guidelines apply.
Grossman, Thomas A. +2 more
core +2 more sources
FEBS Letters, EarlyView.This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva +5 more
wiley +1 more source
Assessment, development, and application of combustor aerothermal models [PDF]
The gas turbine combustion system design and development effort is an engineering exercise to obtain an acceptable solution to the conflicting design trade-offs between combustion efficiency, gaseous emissions, smoke, ignition, restart, lean blowout ...
Holdeman, J. D. +2 more
core +1 more source
In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS
FEBS Letters, EarlyView.We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka +11 more
wiley +1 more source
Discover ChemistryThe present research study outlines the development and validation of a cost-effective, eco-sustainable, and robust analytical procedure for the quantitative estimation of Ritonavir in bulk and tablet dosage form using UV Spectrophotometry and Reverse ...
Vaibhav Sawale +3 more
doaj +1 more source
ANALISIS PENGARUH KUALITAS PRODUK, HARGA, DESAIN PRODUK DAN WORD OF MOUTH TERHADAP KEPUTUSAN PEMBELIAN PADA PRODUK SARUNG TINJU MEREK “AN-DA” DI JAWA TENGAH [PDF]
, 2017 This study aims to analyze the influence of product quality, price, product design, and word of mouth of AN-DA boxing gloves purchase decision in Central Java.
FIRDAUS, Faisal, SUDARYANTO , Budi
core
Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions
FEBS Letters, EarlyView.We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva +10 more
wiley +1 more source
Scalable RAN Virtualization in Multi-Tenant LTE-A Heterogeneous Networks (Extended version)
, 2015 Cellular communications are evolving to facilitate the current and expected increasing needs of Quality of Service (QoS), high data rates and diversity of offered services.
Adelantado, Ferran +2 more
core +1 more source