Results 131 to 140 of about 1,564,973 (286)

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

FEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman, Anna E. Lester, Brian D. Zoltowski   +2 more
wiley   +1 more source

Development of a quality by design-based ultra-performance liquid chromatography method for the simultaneous estimation of casirivimab and imdevimab with greenness metrics

Green Analytical Chemistry
This study presents the development and optimization of an ultra-performance liquid chromatography method for the simultaneous analysis of casirivimab and imdevimab, guided by the principles of Quality by Design.
Sravanthi Gandu, Kumaraswamy Gandla
doaj   +1 more source

Determination of Bupropion and Its Impurities via a Chaotropic Chromatography Method Following Analytical Quality-by-Design Principles for Method Development. [PDF]

Pharmaceuticals (Basel), 2022
Gkountanas K, Malenović A, Dotsikas Y.
europepmc   +1 more source

ANALYTICAL QUALITY by DESIGN – A REVIEW

INDIAN RESEARCH JOURNAL OF PHARMACY AND SCIENCE, 2020
Asmita Mahapatra, Subramania Nainar Meyyanathan   +1 more
openaire   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Development of an Analytical Method for Determination of Related Substances and Degradation Products of Cabotegravir Using Analytical Quality by Design Principles. [PDF]

ACS Omega, 2022
Kovač L, Časar Z, Trdan Lušin T, Roškar R.   +3 more
europepmc   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Analytical quality by design aided RP-HPLC method for the estimation of sunset yellow in commercial food samples employing green ultrasound assisted extraction: Greenness, blueness and whiteness evaluation

Green Analytical Chemistry
Sunset Yellow FCF (E110) is a widely utillized azo synthetic food colorant due to its appealing hue and significant market popularity. Attributable to the health risks caused by excessive usage of Sunset Yellow, ecologically safe method for quantifying ...
Atyurmila Chakraborty, Kavitha Jayaseelan   +1 more
doaj   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

Analytical quality by design methodology for botanical raw material analysis: a case study of flavonoids in Genkwa Flos. [PDF]

Sci Rep, 2021
Kim MK, Park SC, Park G, Choi E, Ji Y, Jang YP.   +5 more
europepmc   +1 more source