Development of D-box peptides to inhibit the anaphase-promoting complex/cyclosome [PDF]
eLifeE3 ubiquitin ligases engage their substrates via ‘degrons’ - short linear motifs typically located within intrinsically disordered regions of substrates.
Rohan Eapen +12 more
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Interplay between Phosphatases and the Anaphase-Promoting Complex/Cyclosome in Mitosis [PDF]
Cells, 2019 Accurate division of cells into two daughters is a process that is vital to propagation of life. Protein phosphorylation and selective degradation have emerged as two important mechanisms safeguarding the delicate choreography of mitosis.
Meghna Kataria, Hiroyuki Yamano
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Upregulation of anaphase promoting complex (APC) 7 as a prognostic marker for esophageal squamous cell carcinoma: A hospital based study [PDF]
Heliyon, 2022 Esophageal cancer is the sixth leading cause of cancer death, and esophageal squamous cell carcinoma (ESCC) is the most prevalent type worldwide, with a poor prognosis due to late diagnosis.
Eyashin Ali +9 more
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Small Molecules Identified by an In Silico Docking Screen Targeting Anaphase-Promoting Complex/Cyclosome Subunit 1 (APC1) Potentiate Paclitaxel-Induced Breast Cancer Cell Death [PDF]
MoleculesDelaying mitotic cell cycle progression has been proposed as a strategy to potentiate the effects of anti-mitotic anti-cancer drugs that induce multipolar mitotic spindles. Toward this end, we have performed an in silico docking screen targeting anaphase-
Scott C. Schuyler +4 more
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The Role of Anaphase-Promoting Complex/Cyclosome (APC/C) in Plant Reproduction [PDF]
Frontiers in Plant Science, 2021 Most eukaryotic species propagate through sexual reproduction that requires male and female gametes. In flowering plants, it starts through a single round of DNA replication (S phase) and two consecutive chromosome segregation (meiosis I and II ...
Marina de Lyra Soriano Saleme +2 more
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Regulated interaction of ID2 with the anaphase-promoting complex links progression through mitosis with reactivation of cell-type-specific transcription [PDF]
Nature Communications, 2022 Tissue-specific transcriptional activity is silenced in mitotic cells. Here the authors reveal a general phosphorylation-dependent mechanism of recognition for the anaphase-promoting complex (APC) substrates, and show that the APC targets ID2 during the ...
Sang Bae Lee +10 more
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The Anaphase-Promoting Complex (APC) ubiquitin ligase affects chemosensory behavior in C. elegans [PDF]
PeerJ, 2016 The regulation of fundamental aspects of neurobiological function has been linked to the ubiquitin signaling system (USS), which regulates the degradation and activity of proteins and is catalyzed by E1, E2, and E3 enzymes. The Anaphase-Promoting Complex
Julia Wang +2 more
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Reciprocal Regulation between 53BP1 and the Anaphase-Promoting Complex/Cyclosome Is Required for Genomic Stability during Mitotic Stress [PDF]
Cell Reports, 2017 The anaphase-promoting complex/cyclosome (APC/C) is an E3 ubiquitin ligase that targets substrates for degradation to promote mitotic progression. Here, we show that the DNA damage response protein 53BP1 contains conserved KEN boxes that are required for
Thomas J. Kucharski +4 more
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Cyclin B3 activates the Anaphase-Promoting Complex/Cyclosome in meiosis and mitosis. [PDF]
PLoS Genetics, 2020 In mitosis and meiosis, chromosome segregation is triggered by the Anaphase-Promoting Complex/Cyclosome (APC/C), a multi-subunit ubiquitin ligase that targets proteins for degradation, leading to the separation of chromatids.
Damien Garrido +5 more
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Mechanisms for the temporal regulation of substrate ubiquitination by the anaphase-promoting complex/cyclosome [PDF]
Cell Division, 2019 The anaphase-promoting complex/cyclosome (APC/C) is a multi-subunit, multifunctional ubiquitin ligase that controls the temporal degradation of numerous cell cycle regulatory proteins to direct the unidirectional cell cycle phases.
Shivangee Bansal, Swati Tiwari
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