Interplay between Phosphatases and the Anaphase-Promoting Complex/Cyclosome in Mitosis [PDF]
Cells, 2019 Accurate division of cells into two daughters is a process that is vital to propagation of life. Protein phosphorylation and selective degradation have emerged as two important mechanisms safeguarding the delicate choreography of mitosis.
Meghna Kataria, Hiroyuki Yamano
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The Role of Anaphase-Promoting Complex/Cyclosome (APC/C) in Plant Reproduction [PDF]
Frontiers in Plant Science, 2021 Most eukaryotic species propagate through sexual reproduction that requires male and female gametes. In flowering plants, it starts through a single round of DNA replication (S phase) and two consecutive chromosome segregation (meiosis I and II ...
Marina de Lyra Soriano Saleme +2 more
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Cyclin B3 activates the Anaphase-Promoting Complex/Cyclosome in meiosis and mitosis. [PDF]
PLoS Genetics, 2020 In mitosis and meiosis, chromosome segregation is triggered by the Anaphase-Promoting Complex/Cyclosome (APC/C), a multi-subunit ubiquitin ligase that targets proteins for degradation, leading to the separation of chromatids.
Damien Garrido +5 more
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Mechanisms for the temporal regulation of substrate ubiquitination by the anaphase-promoting complex/cyclosome [PDF]
Cell Division, 2019 The anaphase-promoting complex/cyclosome (APC/C) is a multi-subunit, multifunctional ubiquitin ligase that controls the temporal degradation of numerous cell cycle regulatory proteins to direct the unidirectional cell cycle phases.
Shivangee Bansal, Swati Tiwari
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The Plant Anaphase-Promoting Complex/Cyclosome.
Annual Review of Cell and Developmental Biology, 2022 The anaphase-promoting complex/cyclosome (APC/C) represents a large multisubunit E3-ubiquitin ligase complex that controls the unidirectional progression through the cell cycle by the ubiquitination of specific target proteins, marking them for ...
Alex Willems, L. De Veylder
semanticscholar +4 more sources
The role of Anaphase Promoting Complex activation, inhibition and substrates in cancer development and progression. [PDF]
Aging (Albany NY), 2020 The Anaphase Promoting Complex (APC), a multi-subunit ubiquitin ligase, facilitates mitotic and G1 progression, and is now recognized to play a role in maintaining genomic stability. Many APC substrates have been observed overexpressed in multiple cancer
VanGenderen C, Harkness TAA, Arnason TG.
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Identification of anaphase promoting complex substrates in S. cerevisiae. [PDF]
PLoS ONE, 2012 The Anaphase-Promoting Complex/Cyclosome (APC/C) is an essential ubiquitin ligase that targets numerous proteins for proteasome-mediated degradation in mitosis and G1. To gain further insight into cellular pathways controlled by APC/C(Cdh1), we developed
Denis Ostapenko +2 more
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Three-Dimensional Structure of the Anaphase-Promoting Complex [PDF]
Molecular Cell, 2001 The anaphase-promoting complex (APC) is a cell cycle-regulated ubiquitin-protein ligase, composed of at least 11 subunits, that controls progression through mitosis and G1. Using cryo-electron microscopy and angular reconstitution, we have obtained a three-dimensional model of the human APC at a resolution of 24 A.
Christian Gieffers +4 more
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Visualizing the complex functions and mechanisms of the anaphase promoting complex/cyclosome (APC/C) [PDF]
Open Biology, 2017 The anaphase promoting complex or cyclosome (APC/C) is a large multi-subunit E3 ubiquitin ligase that orchestrates cell cycle progression by mediating the degradation of important cell cycle regulators.
Claudio Alfieri +2 more
doaj +2 more sources
Upregulation of anaphase promoting complex (APC) 7 as a prognostic marker for esophageal squamous cell carcinoma: A hospital based study [PDF]
Heliyon, 2022 Esophageal cancer is the sixth leading cause of cancer death, and esophageal squamous cell carcinoma (ESCC) is the most prevalent type worldwide, with a poor prognosis due to late diagnosis.
Eyashin Ali +9 more
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