Interplay between Phosphatases and the Anaphase-Promoting Complex/Cyclosome in Mitosis [PDF]
Cells, 2019 Accurate division of cells into two daughters is a process that is vital to propagation of life. Protein phosphorylation and selective degradation have emerged as two important mechanisms safeguarding the delicate choreography of mitosis.
Meghna Kataria, Hiroyuki Yamano
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The Role of Anaphase-Promoting Complex/Cyclosome (APC/C) in Plant Reproduction [PDF]
Frontiers in Plant Science, 2021 Most eukaryotic species propagate through sexual reproduction that requires male and female gametes. In flowering plants, it starts through a single round of DNA replication (S phase) and two consecutive chromosome segregation (meiosis I and II ...
Marina de Lyra Soriano Saleme +2 more
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A decade of the anaphase-promoting complex in the nervous system [PDF]
Genes & Development, 2016 Control of protein abundance by the ubiquitin–proteasome system is essential for normal brain development and function. Just over a decade ago, the first post-mitotic function of the anaphase-promoting complex, a major cell cycle-regulated E3 ubiquitin ...
Bonni, Azad, Huang, Ju
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Cyclin B3 activates the Anaphase-Promoting Complex/Cyclosome in meiosis and mitosis. [PDF]
PLoS Genetics, 2020 In mitosis and meiosis, chromosome segregation is triggered by the Anaphase-Promoting Complex/Cyclosome (APC/C), a multi-subunit ubiquitin ligase that targets proteins for degradation, leading to the separation of chromatids.
Damien Garrido +5 more
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Mechanisms for the temporal regulation of substrate ubiquitination by the anaphase-promoting complex/cyclosome [PDF]
Cell Division, 2019 The anaphase-promoting complex/cyclosome (APC/C) is a multi-subunit, multifunctional ubiquitin ligase that controls the temporal degradation of numerous cell cycle regulatory proteins to direct the unidirectional cell cycle phases.
Shivangee Bansal, Swati Tiwari
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Intricate Regulatory Mechanisms of the Anaphase-Promoting Complex/Cyclosome and Its Role in Chromatin Regulation. [PDF]
Front Cell Dev Biol, 2021 The ubiquitin (Ub)-proteasome system is vital to nearly every biological process in eukaryotes. Specifically, the conjugation of Ub to target proteins by Ub ligases, such as the Anaphase-Promoting Complex/Cyclosome (APC/C), is paramount for cell cycle ...
Bodrug T +4 more
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The role of Anaphase Promoting Complex activation, inhibition and substrates in cancer development and progression. [PDF]
Aging (Albany NY), 2020 The Anaphase Promoting Complex (APC), a multi-subunit ubiquitin ligase, facilitates mitotic and G1 progression, and is now recognized to play a role in maintaining genomic stability. Many APC substrates have been observed overexpressed in multiple cancer
VanGenderen C, Harkness TAA, Arnason TG.
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Upregulation of anaphase promoting complex (APC) 7 as a prognostic marker for esophageal squamous cell carcinoma: A hospital based study [PDF]
Heliyon, 2022 Esophageal cancer is the sixth leading cause of cancer death, and esophageal squamous cell carcinoma (ESCC) is the most prevalent type worldwide, with a poor prognosis due to late diagnosis.
Eyashin Ali +9 more
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Visualizing the complex functions and mechanisms of the anaphase promoting complex/cyclosome (APC/C) [PDF]
Open Biology, 2017 The anaphase promoting complex or cyclosome (APC/C) is a large multi-subunit E3 ubiquitin ligase that orchestrates cell cycle progression by mediating the degradation of important cell cycle regulators.
Claudio Alfieri +2 more
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Small Molecules Identified by an In Silico Docking Screen Targeting Anaphase-Promoting Complex/Cyclosome Subunit 1 (APC1) Potentiate Paclitaxel-Induced Breast Cancer Cell Death [PDF]
MoleculesDelaying mitotic cell cycle progression has been proposed as a strategy to potentiate the effects of anti-mitotic anti-cancer drugs that induce multipolar mitotic spindles. Toward this end, we have performed an in silico docking screen targeting anaphase-
Scott C. Schuyler +4 more
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