Results 91 to 100 of about 54,411 (234)

Regulation of the anaphase-promoting complex by the COP9 signalosome [PDF]

Cell Cycle, 2009
The COP9 complex (signalosome) is a known regulator of the proteasome/ubiquitin pathway. Furthermore it regulates the activity of the cullin-RING ligase (CRL) families of ubiquitin E3-complexes. Besides the CRL family, the anaphase-promoting complex (APC/C) is a major regulator of the cell cycle.
Robert, Kob, Juliane, Kelm, Nicole, Posorski, Aria, Baniahmad, Ferdinand, von Eggeling, Christian, Melle   +5 more
openaire   +2 more sources

RNase H enables efficient repair of R-loop induced DNA damage. [PDF]

, 2016
R-loops, three-stranded structures that form when transcripts hybridize to chromosomal DNA, are potent agents of genome instability. This instability has been explained by the ability of R-loops to induce DNA damage. Here, we show that persistent R-loops
Amon, Jeremy D, Koshland, Douglas
core   +1 more source

Calpain Proteases and the Evolving Signaling Network in Insect Embryonic Patterning

Journal of Experimental Zoology Part B: Molecular and Developmental Evolution, EarlyView.
Insect embryonic Dorsal‐Ventral (DV) patterning relies on the BMP and Toll pathways to different extents. Calcium‐dependent cystein proteases of the Calpain family also exert an important function to pattern the DV axis. In Drosophila, Calpain A cleaves the Cactus/IkappaB inhibitor and modifies Toll signals in ventral regions of the embryo. In Rhodnius
Alison Julio, Helena Araujo
wiley   +1 more source

The Anaphase-Promoting Complex/Cyclosome in Control of Plant Development [PDF]

Molecular Plant, 2012
Temporal controlled degradation of key cell division proteins ensures a correct onset of the different cell cycle phases and exit from the cell division program. In light of the cell cycle, the Anaphase-Promoting Complex/Cyclosome (APC/C) is an important conserved multi-subunit ubiquitin ligase, marking targets for degradation by the 26S proteasome ...
Heyman, Jefri, De Veylder, Lieven
openaire   +2 more sources

Spindle assembly checkpoint is sufficient for complete Cdc20 sequestering in mitotic control

Computational and Structural Biotechnology Journal, 2015
The spindle checkpoint assembly (SAC) ensures genome fidelity by temporarily delaying anaphase onset, until all chromosomes are properly attached to the mitotic spindle.
Bashar Ibrahim
doaj   +1 more source

The importance of CDC27 in cancer: molecular pathology and clinical aspects

Cancer Cell International, 2021
Background CDC27 is one of the core components of Anaphase Promoting complex/cyclosome. The main role of this protein is defined at cellular division to control cell cycle transitions. Here we review the molecular aspects that may affect CDC27 regulation
Golnaz Ensieh Kazemi-Sefat, Mohammad Keramatipour, Saeed Talebi, Kaveh Kavousi, Roya Sajed, Nazanin Atieh Kazemi-Sefat, Kazem Mousavizadeh   +6 more
doaj   +1 more source

Latrunculin A delays anaphase onset in fission yeast by disrupting an ase1-independent pathway controlling mitotic spindle stability [PDF]

, 2008
It has been proposed previously that latrunculin A, an inhibitor of actin polymerization, delays the onset of anaphase by causing spindle misorientation in fission yeast.
Meadows, John C., Millar, Jonathan B. A.
core   +2 more sources

Exploration of Therapeutic Targets Using CDK4 Inhibitors for Head and Neck Mucosal Melanoma

Otolaryngology–Head and Neck Surgery, EarlyView.
Abstract Objective Mucosal melanoma (MM) is an extremely aggressive malignant tumor in the head and neck region associated with a poor prognosis. In the present study, we conducted cell proliferation assay and western blotting using cell lines derived from MM and the immunohistochemical analysis of pathological MM tissues to identify novel therapeutic ...
Takayoshi Hattori, Makiko Fujii, Tsutomu Ueda, Akira Ishikawa, Yuichi Mine, Bingwen Xu, Tomoya Suehiro, Minoru Hattori, Hiroaki Tahara, Yuki Sato, Nobuyuki Chikuie, Takayuki Taruya, Takao Hamamoto, Takashi Ishino, Sachio Takeno   +14 more
wiley   +1 more source

The human SKA complex drives the metaphase-anaphase cell cycle transition by recruiting protein phosphatase 1 to kinetochores

eLife, 2016
The spindle- and kinetochore-associated (Ska) complex is essential for normal anaphase onset in mitosis. The C-terminal domain (CTD) of Ska1 binds microtubules and was proposed to facilitate kinetochore movement on depolymerizing spindle microtubules ...
Sushama Sivakumar, Paweł Ł Janczyk, Qianhui Qu, Chad A Brautigam, P Todd Stukenberg, Hongtao Yu, Gary J Gorbsky   +6 more
doaj   +1 more source

Cdc13 (cyclin B) is degraded by autophagy under sulfur depletion in fission yeast

Autophagy Reports, 2022
Cyclins are degraded by the anaphase-promoting complex/cyclosome (APC/C)-mediated proteasome in normal mitosis. We showed that Cdc13 (cyclin B) is also degraded by macroautophagy/autophagy in sulfur-deficient fission yeast.
Hokuto Ohtsuka, Yoshiko Hatta, Kana Hayashi, Takafumi Shimasaki, Yoko Otsubo, Yurika Ito, Yu Tsutsui, Nobutake Hattori, Akira Yamashita, Hiroshi Murakami, Hirofumi Aiba   +10 more
doaj   +1 more source