Results 101 to 110 of about 282,951 (269)
Making Two out of One: Kinesin Motors Driving Plant Cell Division
Cytoskeleton, EarlyView.ABSTRACT The Kinesin superfamily of microtubule dependent motors is present in all eukaryotes. Not all of the subfamilies are represented in all kingdoms, and the ones that are do not always show conserved functions. Tight control of the cytoskeleton is essential for proper progression and completion of mitosis and cytokinesis, and key functions are ...
Choy Kriechbaum, Sabine Müller
wiley +1 more source
Processive ubiquitin chain formation by the anaphase-promoting complex [PDF]
Seminars in Cell & Developmental Biology, 2011 Progression through mitosis requires the sequential ubiquitination of cell cycle regulators by the anaphase-promoting complex, resulting in their proteasomal degradation. Although several mechanisms contribute to APC/C regulation during mitosis, the APC/C is able to discriminate between its many substrates by exploiting differences in the processivity ...
Michael Rape, Hermann-Josef Meyer
openaire +2 more sources
Transitions Regulating the Timing of Cytokinesis in Embryonic Cells [PDF]
, 2002 Anaphase, mitotic exit, and cytokinesis proceed in rapid succession, and while mitotic exit is a requirement for cytokinesis in yeast [1, 2], it may not be a direct requirement for furrow initiation in animal cells [3, 4].
Sigrist +24 more
core +1 more source
An Orthogonal Way of Writing the Tubulin Code
Cytoskeleton, EarlyView.ABSTRACT The Elongator complex has long been characterized for its role in tRNA modification and modulation of protein translation. Beyond these established functions, recent findings reveal an unexpected role for Elongator in directly interacting and tuning microtubule dynamics and properties, broadening its biological significance in eukaryotic cells.
Vicente Jose Planelles‐Herrero +1 more
wiley +1 more source
The Bub1–Plk1 kinase complex promotes spindle checkpoint signalling through Cdc20 phosphorylation
Nature Communications, 2016 The mitotic checkpoint complex (MCC) inhibits the anaphase-promoting complex (APC/C) bound to Cdc20 in response to spindle defects. Here, the authors show that Bub1-Plk1-mediated phosphorylation of Cdc20 constitutes a parallel, non-redundant APC/C ...
Luying Jia, Bing Li, Hongtao Yu
doaj +1 more source
Biology Open, 2017 Kinetochores move chromosomes on dynamic spindle microtubules and regulate signaling of the spindle checkpoint. The spindle- and kinetochore-associated (Ska) complex, a hexamer composed of two copies of Ska1, Ska2 and Ska3, has been implicated in both ...
Sushama Sivakumar, Gary J. Gorbsky
doaj +1 more source
Control the host cell cycle: Viral regulation of the anaphase-promoting complex [PDF]
, 2013 Viruses commonly manipulate cell cycle progression to create cellular conditions that are most beneficial to their replication. To accomplish this feat, viruses often target critical cell cycle regulators in order to have maximal effect with minimal ...
Fehr, Anthony R, Yu, Dong
core +2 more sources
Drug Discovery Applications of Nitroso (Hetero)Arene Derivatives
ChemPlusChem, EarlyView.Nitroso (hetero)aromatic compounds are bioactive molecules with antiviral, anticancer, neuroprotective, and antimicrobial properties. This review highlights their mechanisms of action—oxidative stress, DNA damage, and enzyme inhibition—alongside synthesis, structure–activity relationships, and toxicity challenges, offering insight into their ...
Silvia Roscales, Aurelio G. Csáky
wiley +1 more source
Latrunculin A delays anaphase onset in fission yeast by disrupting an ase1-independent pathway controlling mitotic spindle stability [PDF]
, 2008 It has been proposed previously that latrunculin A, an inhibitor of actin polymerization, delays the onset of anaphase by causing spindle misorientation in fission yeast.
Meadows, John C., Millar, Jonathan B. A.
core +2 more sources
Aging, 2016 The Saccharomyces cerevisiae Forkhead Box (Fox) orthologs, Forkheads (Fkh) 1 and 2, are conserved transcription factors required for stress response, cell cycle progression and longevity.
M. Malo +3 more
semanticscholar +1 more source