Results 121 to 130 of about 282,951 (269)
مجله دانشکده پزشکی اصفهان, 2013 Background: Anaphase promoting complex (APC) plays a critical role in cell division and mitotic exit. This protein complex may have a pivotal role in the cell cycle control affecting pathological conditions such as cancer.
Hamzeh Rahimi +5 more
doaj
eLife, 2016 The spindle- and kinetochore-associated (Ska) complex is essential for normal anaphase onset in mitosis. The C-terminal domain (CTD) of Ska1 binds microtubules and was proposed to facilitate kinetochore movement on depolymerizing spindle microtubules ...
Sushama Sivakumar +6 more
doaj +1 more source
Cdc13 (cyclin B) is degraded by autophagy under sulfur depletion in fission yeast
Autophagy Reports, 2022 Cyclins are degraded by the anaphase-promoting complex/cyclosome (APC/C)-mediated proteasome in normal mitosis. We showed that Cdc13 (cyclin B) is also degraded by macroautophagy/autophagy in sulfur-deficient fission yeast.
Hokuto Ohtsuka +10 more
doaj +1 more source
Nuclear-localized subtype of end-binding 1 protein regulates spindle organization in Arabidopsis [PDF]
, 2010 End-binding 1 (EB1) proteins are evolutionarily conserved plus-end-tracking proteins that localize to growing microtubule plus ends where they regulate microtubule dynamics and interactions with intracellular targets.
Abe, Tatsuya +5 more
core +2 more sources
Cancer Science, EarlyView.M12BD deficiency increases a chromosomal aneuploidy, particularly trisomy of chromosomes 6 and 10. ABSTRACT CENP‐C, an essential component of the kinetochore, connects centromeric chromatin to the outer kinetochore, and thereby ensures accurate chromosome segregation.
Megumi Saito +10 more
wiley +1 more source
The importance of CDC27 in cancer: molecular pathology and clinical aspects
Cancer Cell International, 2021 Background CDC27 is one of the core components of Anaphase Promoting complex/cyclosome. The main role of this protein is defined at cellular division to control cell cycle transitions. Here we review the molecular aspects that may affect CDC27 regulation
Golnaz Ensieh Kazemi-Sefat +6 more
doaj +1 more source
RNase H enables efficient repair of R-loop induced DNA damage. [PDF]
, 2016 R-loops, three-stranded structures that form when transcripts hybridize to chromosomal DNA, are potent agents of genome instability. This instability has been explained by the ability of R-loops to induce DNA damage. Here, we show that persistent R-loops
Amon, Jeremy D, Koshland, Douglas
core +1 more source
YKT6 Is Essential for Male Fertility by Promoting Meiosis Progression During Spermatogenesis of Mice
Cell Proliferation, EarlyView.Specifically ablating Ykt6 in pre‐meiotic germ cells and meiotic spermatocytes leads to complete sterility and meiotic arrest in conditional knockout male mice. YTK6 is required for stabilising intercellular bridges between spermatocytes due to its key role in maintaining protein homeostasis and vesicular transport‐dependent functions in spermatocytes,
Jie Cen +8 more
wiley +1 more source
OncoTarget, 2016 Cancer dormancy is a stage in tumor progression in which residual disease remains occult and asymptomatic for a prolonged period. Cancer cell dormancy is the main cause of cancer recurrence and failure of therapy.
Yafei Dai +11 more
semanticscholar +1 more source
Cell Proliferation, EarlyView.Maternal TCF12 ensures the competence of fertilisation by controlling the expression of Astl and the proper location of cortical granules. Furthermore, maternal TCF12 maintains the phosphatase activity of PP2A by regulating the expression of Arpp19. Oocyte‐specific deletion of Tcf12 leads to fertilisation defects as well as ZGA failure at the 2‐cell ...
Lan‐Rui Cao +7 more
wiley +1 more source