Results 121 to 130 of about 53,781 (249)

HIM-10 is required for kinetochore structure and function on Caenorhabditis elegans holocentric chromosomes. [PDF]

, 2001
Macromolecular structures called kinetochores attach and move chromosomes within the spindle during chromosome segregation. Using electron microscopy, we identified a structure on the holocentric mitotic and meiotic chromosomes of Caenorhabditis elegans ...
Albertson, Albertson, Albertson, Amon, Buchwitz, Dernburg, Fire, Gonczy, Harlow, Heald, Hedgecock, Hodgkin, Howman, Kainta, Kimble, Lombillo, Maney, McDonald, McEwen, Mello, Moore, Nabetani, Newman, Nicklas, O'Connell, Rappleye, Roos, Savoian, Shah, Sharp, Sharp, Wigge, Yanagida, Yao   +33 more
core   +2 more sources

Loss of E3 ligase HvST1 function substantially increases distal crossover frequency

New Phytologist, EarlyView.
Summary This study characterizes the function of a grass‐specific E3 ubiquitin ligase, HvST1, in regulating synapsis and crossover (CO) formation during meiosis in barley (Hordeum vulgare). In large‐genome cereals, COs are predominantly restricted to distal chromosomal regions, limiting genetic recombination and breeding flexibility.
Jamie Neil Orr, Sybille Ursula Mittmann, Luke Ramsay, Dominika Lewandowska, Abdellah Barakate, Malcolm Macaulay, Nicola McCallum, Robbie Waugh, Isabelle Colas   +8 more
wiley   +1 more source

Purification and Assay of the Budding Yeast Anaphase‐Promoting Complex [PDF]

, 2005
The anaphase-promoting complex (APC) is a central regulator of the eukaryotic cell cycle and functions as an E3 ubiquitin protein ligase to catalyze the ubiquitination of a number of cell cycle regulatory proteins. The APC contains at least 13 subunits in addition to two activator subunits, Cdc20 and Cdh1, that associate with the APC in a cell cycle ...
Lori A, Passmore, David, Barford, J Wade, Harper   +2 more
openaire   +2 more sources

PLK4 is a potential therapeutic target in nonmelanoma skin cancers: Evidence from molecular and in vivo studies

Photochemistry and Photobiology, EarlyView.
Exposure to solar ultraviolet radiation is the main etiologic driver of nonmelanoma skin cancers (NMSCs), including basal cell (BCC) and cutaneous squamous cell carcinomas (cSCC), which are the most prevalent types of cancers in the US. In this study, we demonstrate that the serine/threonine kinase Polo‐like kinase 4 (PLK4) is overexpressed in NMSCs ...
Mary A. Ndiaye, Debra R. Garvey, Gagan Chhabra, Chandra K. Singh, Minakshi Nihal, Nihal Ahmad   +5 more
wiley   +1 more source

Interplay between c-Src and the APC/C co-activator Cdh1 regulates mammary tumorigenesis

Nature Communications, 2019
The Anaphase Promoting Complex adaptor protein Cdh1 tightly controls cell cycle progression to restrain tumorigenesis but the mechanism is not completely known.
Tao Han, Shulong Jiang, Hong Zheng, Qing Yin, Mengyu Xie, Margaret R Little, Xiu Yin, Ming Chen, Su Jung Song, Amer A. Beg, Pier Paolo Pandolfi, Lixin Wan   +11 more
doaj   +1 more source

Sex differences in the physiological response to acute anterior cruciate ligament overuse

The Journal of Physiology, EarlyView.
Abstract figure legend With equivalent in vivo fatigue loading of the anterior cruciate ligament (ACL), females accumulate more tissue damage and mount a slower reparative response than males, when the applied loads between sexes are equivalent. By contrast, males accumulate less tissue damage and mount a robust reparative response that includes ...
Stephen H. Schlecht, Benjamin E. Loflin, Adam R. Carter, Roufael Hanna, Simran Shergill, Edward M. Wojtys   +5 more
wiley   +1 more source

Genomic evolution and complexity of the Anaphase-promoting Complex (APC) in land plants

BMC Plant Biology, 2010
Background The orderly progression through mitosis is regulated by the Anaphase-Promoting Complex (APC), a large multiprotein E3 ubiquitin ligase that targets key cell-cycle regulators for destruction by the 26 S proteasome.
Hemerly Adriana S, de Oliveira Antonio, Elofsson Arne, Vargas Lívia, Bretz Thiago, Rojas Cristian, Sagit Rauan, Pegoraro Camila, Eloy Núbia B, Lima Marcelo de F, Ferreira Paulo CG   +10 more
doaj   +1 more source

Epigenomics‐guided precision oncology: Chromatin variants in prostate tumor evolution

International Journal of Cancer, Volume 158, Issue 2, Page 314-332, 15 January 2026.
Abstract Prostate cancer is a common malignancy that in 5%–30% leads to treatment‐resistant and highly aggressive disease. Metastasis‐potential and treatment‐resistance is thought to rely on increased plasticity of the cancer cells—a mechanism whereby cancer cells alter their identity to adapt to changing environments or therapeutic pressures to create
Kira Furlano, Tina Keshavarzian, Nadine Biernath, Annika Fendler, Maria de Santis, Joachim Weischenfeldt, Mathieu Lupien   +6 more
wiley   +1 more source

Maternal age-dependent APC/C-mediated decrease in securin causes premature sister chromatid separation in meiosis II

Nature Communications, 2017
Sister chromatid cohesion during meiosis II (MII), maintained by securin-mediated inhibition of separase, is reduced in aged mouse oocytes. Here the authors show that, in MII oocytes, securin levels are reduced by increased destruction by the anaphase ...
Ibtissem Nabti, Rosanna Grimes, Hema Sarna, Petros Marangos, John Carroll   +4 more
doaj   +1 more source

Antagonistic Gcn5-Hda1 interactions revealed by mutations to the Anaphase Promoting Complex in yeast

Cell Division, 2011
Background Histone post-translational modifications are critical for gene expression and cell viability. A broad spectrum of histone lysine residues have been identified in yeast that are targeted by a variety of modifying enzymes.
Malo Mackenzie E, Menzel Johannes, Turner Emma L, Islam Azharul, Harkness Troy AA   +4 more
doaj   +1 more source