Results 121 to 130 of about 54,411 (234)

Interplay between c-Src and the APC/C co-activator Cdh1 regulates mammary tumorigenesis

Nature Communications, 2019
The Anaphase Promoting Complex adaptor protein Cdh1 tightly controls cell cycle progression to restrain tumorigenesis but the mechanism is not completely known.
Tao Han, Shulong Jiang, Hong Zheng, Qing Yin, Mengyu Xie, Margaret R Little, Xiu Yin, Ming Chen, Su Jung Song, Amer A. Beg, Pier Paolo Pandolfi, Lixin Wan   +11 more
doaj   +1 more source

Maternal age-dependent APC/C-mediated decrease in securin causes premature sister chromatid separation in meiosis II

Nature Communications, 2017
Sister chromatid cohesion during meiosis II (MII), maintained by securin-mediated inhibition of separase, is reduced in aged mouse oocytes. Here the authors show that, in MII oocytes, securin levels are reduced by increased destruction by the anaphase ...
Ibtissem Nabti, Rosanna Grimes, Hema Sarna, Petros Marangos, John Carroll   +4 more
doaj   +1 more source

Genomic evolution and complexity of the Anaphase-promoting Complex (APC) in land plants

BMC Plant Biology, 2010
Background The orderly progression through mitosis is regulated by the Anaphase-Promoting Complex (APC), a large multiprotein E3 ubiquitin ligase that targets key cell-cycle regulators for destruction by the 26 S proteasome.
Hemerly Adriana S, de Oliveira Antonio, Elofsson Arne, Vargas Lívia, Bretz Thiago, Rojas Cristian, Sagit Rauan, Pegoraro Camila, Eloy Núbia B, Lima Marcelo de F, Ferreira Paulo CG   +10 more
doaj   +1 more source

Antagonistic Gcn5-Hda1 interactions revealed by mutations to the Anaphase Promoting Complex in yeast

Cell Division, 2011
Background Histone post-translational modifications are critical for gene expression and cell viability. A broad spectrum of histone lysine residues have been identified in yeast that are targeted by a variety of modifying enzymes.
Malo Mackenzie E, Menzel Johannes, Turner Emma L, Islam Azharul, Harkness Troy AA   +4 more
doaj   +1 more source

Precocious activation of APC/C-Cdh1 at pre-anaphase causes genome instability [PDF]

, 2008
Faithful chromosome segregation and thereby accurate gene transmission are crucial for all organisms. Until proper attachment of the mitotic spindle to the kinetochore is established, the ubiquitin ligase (E3) Cdc20-activated APC/C (anaphase promoting ...
Asuka Suzuki, Ayumu Yamamoto, Kazuhiro Toda, Masahiro Uritani, Masaru Ueno, Takanori Ohyoshi, Takashi Ushimaru   +6 more
core   +1 more source

Purification and Assay of the Budding Yeast Anaphase‐Promoting Complex [PDF]

, 2005
The anaphase-promoting complex (APC) is a central regulator of the eukaryotic cell cycle and functions as an E3 ubiquitin protein ligase to catalyze the ubiquitination of a number of cell cycle regulatory proteins. The APC contains at least 13 subunits in addition to two activator subunits, Cdc20 and Cdh1, that associate with the APC in a cell cycle ...
Lori A, Passmore, David, Barford, J Wade, Harper   +2 more
openaire   +2 more sources

Linear ubiquitination of p31comet by HOIP couples cytokine response with mitotic regulation

Cell & Bioscience
Background Inflammation and genomic instability are among the hallmarks of human cancer. Proinflammatory cytokines induce DNA damage through the accumulation of reactive oxygen and nitrogen species (RONS), which often leads to base alternations. The link
Yifeng Gao, Qing Yin, Yaser Gamallat, Michael G. Grant, Aidan H. Snell, Xingxing Shi, Lara N. Ulstad, Arshita Singh, Tingan Chen, Joseph O. Johnson, Dorina Avram, Lixin Wan   +11 more
doaj   +1 more source

CHMP4C: A novel regulator of the mitotic spindle checkpoint

Molecular & Cellular Oncology, 2018
The mitotic spindle checkpoint delays anaphase onset until all chromosomes have achieved stable kinetochore-microtubule attachments. Here, we discuss recent findings showing that CHMP4C, a component of the endosomal sorting complex required for transport
Eleni Petsalaki, George Zachos
doaj   +1 more source

Overexpression of the Anaphase Promoting Complex/Cyclosome Inhibitor Emi1 Leads to Tetraploidy and Genomic Instability of p53-Deficient Cells [PDF]

, 2006
Norman L. Lehman, Emmy W. Verschuren, Jerry Y. Hsu, Athena M. Cherry, Peter K. Jackson   +4 more
openalex   +1 more source

Anaphase-promoting Complex/Cyclosome-mediated Proteolysis of Ams2 in the G1 Phase Ensures the Coupling of Histone Gene Expression to DNA Replication in Fission Yeast [PDF]

, 2012
Michelle Trickey, Kazuyuki Fujimitsu, Hiroyuki Yamano   +2 more
openalex   +1 more source