Results 131 to 140 of about 53,781 (249)

The Double Face of Base Excision Repair: Preventing and Triggering Double‐Strand Breaks

BioEssays, Volume 48, Issue 1, January 2026.
Base excision repair is conserved from bacteria to man, robustly eliminating oxidized bases in DNA and reinserting the appropriate nucleotide to restore an intact double helix. Recent results describe conditions and mechanisms that misregulate long‐patch BER to generate double‐strand breaks, triggering chromosome fragmentation and cell death, altering ...
Susan M. Gasser
wiley   +1 more source

Where, When, and How? Integrating Spatiotemporal Cues in Cell Division

BioEssays, Volume 48, Issue 1, January 2026.
Accurate chromosome segregation during mitosis depends on the spatial and temporal regulation of spindle assembly, kinetochore‐microtubule attachment, and checkpoint signaling. Here, we highlight how mitotic chromosomes can serve as dynamic hubs that integrate molecular cues to coordinate spindle organization and timing, ensuring faithful genome ...
Luca Cirillo, Hradini Konthalapalli, Claudio Alfieri, Jonathon Pines   +3 more
wiley   +1 more source

Linear ubiquitination of p31comet by HOIP couples cytokine response with mitotic regulation

Cell & Bioscience
Background Inflammation and genomic instability are among the hallmarks of human cancer. Proinflammatory cytokines induce DNA damage through the accumulation of reactive oxygen and nitrogen species (RONS), which often leads to base alternations. The link
Yifeng Gao, Qing Yin, Yaser Gamallat, Michael G. Grant, Aidan H. Snell, Xingxing Shi, Lara N. Ulstad, Arshita Singh, Tingan Chen, Joseph O. Johnson, Dorina Avram, Lixin Wan   +11 more
doaj   +1 more source

CHMP4C: A novel regulator of the mitotic spindle checkpoint

Molecular & Cellular Oncology, 2018
The mitotic spindle checkpoint delays anaphase onset until all chromosomes have achieved stable kinetochore-microtubule attachments. Here, we discuss recent findings showing that CHMP4C, a component of the endosomal sorting complex required for transport
Eleni Petsalaki, George Zachos
doaj   +1 more source

Functional specialization of the yeast Rho1 GTP exchange factors [PDF]

, 2012
Rho GTPases are regulated in complex spatiotemporal patterns that may be dependent, in part at least, on the multiplicity of their GTP exchange factors (GEFs).
Cundell, M., Gray, J., Johnston, G., Krause, S., McGhie, J., Poon, P., Price, C.   +6 more
core  

Diploid origins and early genome stabilization in the allotetraploid Arabidopsis suecica

New Phytologist, Volume 249, Issue 1, Page 524-538, January 2026.
Summary Polyploidization, followed by genome downsizing, is a recurrent evolutionary cycle that dramatically reshapes genome structure. Newly formed polyploids must quickly adjust their cell division machinery to maintain stable chromosome inheritance, while long‐term stabilization involves rediploidization, returning the genome to a diploid‐like state.
Robin Burns, Anna Glushkevich, Aboli Kulkarni, Uliana K. Kolesnikova, Filip Kolář, Alison Dawn Scott, Polina Yu. Novikova   +6 more
wiley   +1 more source

Drug Discovery Applications of Nitroso (Hetero)Arene Derivatives

ChemPlusChem, Volume 90, Issue 12, December 10, 2025.
Nitroso (hetero)aromatic compounds are bioactive molecules with antiviral, anticancer, neuroprotective, and antimicrobial properties. This review highlights their mechanisms of action—oxidative stress, DNA damage, and enzyme inhibition—alongside synthesis, structure–activity relationships, and toxicity challenges, offering insight into their ...
Silvia Roscales, Aurelio G. Csáky
wiley   +1 more source

Mcm10 proteolysis initiates before the onset of M-phase

BMC Cell Biology, 2010
Background Mcm10 protein is essential for initiation and elongation phases of replication. Human cells proteolyze Mcm10 during mitosis, presumably to ensure a single round of replication. It has been proposed that anaphase promoting complex ubiquitinates
Khan Muntaz, Sharma Aparna, Kaur Manpreet, Kar Ananya, Saxena Sandeep   +4 more
doaj   +1 more source

Disruption of the anaphase-promoting complex confers resistance to TTK inhibitors in triple-negative breast cancer [PDF]

, 2018
Kelsie L. Thu, Jennifer Silvester, Mitchell J. Elliott, Wail Ba-Alawi, Meghan Duncan, Andrea C. Elia, Arvind Singh Mer, Petr Smirnov, Zhaleh Safikhani, Benjamin Haibe‐Kains, Tak W. Mak, David W. Cescon   +11 more
openalex   +1 more source

Engineering the Link: From Genome Interaction Maps to Functional Insight

Advanced Biology, Volume 9, Issue 12, December 2025.
Advances in chromosome conformation capture have revealed the genome's 3D organization, yet its causal impact on gene regulation remains elusive. This review highlights emerging genome‐engineering tools ‐ zinc fingers, TALEs, and CRISPR‐Cas9 ‐ that enable targeted manipulation of chromatin loops to dissect structure–function relationships. It discusses
Frido Petersen, Simon Westermann, Valeriia Smialkovska, Jan Mathony, Angelika Feldmann, Dominik Niopek   +5 more
wiley   +1 more source