Results 141 to 150 of about 282,951 (269)

DNA damage in mitosis: SOD1 delays anaphase onset

The FEBS Journal, EarlyView.
Mitotic cells do not exhibit a DNA damage checkpoint delay and do not repair DNA double strand breaks (DSBs) until the next cell cycle. Instead, DSBs can delay anaphase through the mitotic spindle checkpoint, by an incompletely understood mechanism. Li et al.
George Zachos
wiley   +1 more source

Editing a gibberellin receptor gene improves yield and nitrogen fixation in soybean

Journal of Integrative Plant Biology, EarlyView.
Knockout of the soybean gibberellin receptor gene GmGID1‐2 reduced plant height; strengthened stems; increased the number of branches, nodes, pods, and seeds; and improved yield, seed oil content and nitrogen fixation. ABSTRACT Soybean is an important source of oil, protein, and feed. However, its yield is far below that of major cereal crops.
Jiajun Tang, Shuhan Yang, Shuxuan Li, Xiuli Yue, Ting Jin, Xinyu Yang, Kai Zhang, Qianqian Yang, Tengfei Liu, Shancen Zhao, Junyi Gai, Yan Li   +11 more
wiley   +1 more source

Interplay between c-Src and the APC/C co-activator Cdh1 regulates mammary tumorigenesis

Nature Communications, 2019
The Anaphase Promoting Complex adaptor protein Cdh1 tightly controls cell cycle progression to restrain tumorigenesis but the mechanism is not completely known.
Tao Han, Shulong Jiang, Hong Zheng, Qing Yin, Mengyu Xie, Margaret R Little, Xiu Yin, Ming Chen, Su Jung Song, Amer A. Beg, Pier Paolo Pandolfi, Lixin Wan   +11 more
doaj   +1 more source

Targeting the anaphase-promoting complex/cyclosome (APC/C)- bromodomain containing 7 (BRD7) pathway for human osteosarcoma

OncoTarget, 2014
Osteosarcoma is the most common primary malignant bone tumor in childhood and adolescence and has a propensity for local invasion and early lung metastasis.
K. Hu, D. Liao, Wenjing Wu, A. Han, Hui-juan Shi, Fen Wang, Xin Wang, L. Zhong, Tingmei Duan, Yuanzhong Wu, Jingying Cao, Jianjun Tang, Y. Sang, Li Wang, Xiaobin Lv, Shuangbing Xu, Ruhua Zhang, Wuguo Deng, Sheng-ping Li, Y. Zeng, Tiebang Kang   +20 more
semanticscholar   +1 more source

PLK4 is a potential therapeutic target in nonmelanoma skin cancers: Evidence from molecular and in vivo studies

Photochemistry and Photobiology, EarlyView.
Exposure to solar ultraviolet radiation is the main etiologic driver of nonmelanoma skin cancers (NMSCs), including basal cell (BCC) and cutaneous squamous cell carcinomas (cSCC), which are the most prevalent types of cancers in the US. In this study, we demonstrate that the serine/threonine kinase Polo‐like kinase 4 (PLK4) is overexpressed in NMSCs ...
Mary A. Ndiaye, Debra R. Garvey, Gagan Chhabra, Chandra K. Singh, Minakshi Nihal, Nihal Ahmad   +5 more
wiley   +1 more source

Sex differences in the physiological response to acute anterior cruciate ligament overuse

The Journal of Physiology, EarlyView.
Abstract figure legend With equivalent in vivo fatigue loading of the anterior cruciate ligament (ACL), females accumulate more tissue damage and mount a slower reparative response than males, when the applied loads between sexes are equivalent. By contrast, males accumulate less tissue damage and mount a robust reparative response that includes ...
Stephen H. Schlecht, Benjamin E. Loflin, Adam R. Carter, Roufael Hanna, Simran Shergill, Edward M. Wojtys   +5 more
wiley   +1 more source

Maternal age-dependent APC/C-mediated decrease in securin causes premature sister chromatid separation in meiosis II

Nature Communications, 2017
Sister chromatid cohesion during meiosis II (MII), maintained by securin-mediated inhibition of separase, is reduced in aged mouse oocytes. Here the authors show that, in MII oocytes, securin levels are reduced by increased destruction by the anaphase ...
Ibtissem Nabti, Rosanna Grimes, Hema Sarna, Petros Marangos, John Carroll   +4 more
doaj   +1 more source

Antagonistic Gcn5-Hda1 interactions revealed by mutations to the Anaphase Promoting Complex in yeast

Cell Division, 2011
Background Histone post-translational modifications are critical for gene expression and cell viability. A broad spectrum of histone lysine residues have been identified in yeast that are targeted by a variety of modifying enzymes.
Malo Mackenzie E, Menzel Johannes, Turner Emma L, Islam Azharul, Harkness Troy AA   +4 more
doaj   +1 more source

Histone H2B Ubiquitination Promotes the Function of the Anaphase-Promoting Complex/Cyclosome in Schizosaccharomyces pombe

G3: Genes, Genomes, Genetics, 2014
Ubiquitination and deubiquitination of proteins are reciprocal events involved in many cellular processes, including the cell cycle. During mitosis, the metaphase to anaphase transition is regulated by the ubiquitin ligase activity of the anaphase ...
Zachary C. Elmore, Janel R Beckley, Jun-Song Chen, K. Gould   +3 more
semanticscholar   +1 more source

When the Clock Is Ticking: The Role of Mitotic Duration in Cell Fate Determination

BioEssays, Volume 47, Issue 11, November 2025.
Recently, several studies identified mechanisms by which cells measure mitotic duration and how this influences cell fate, leading to normal cell cycle progression or G1 arrest. In light of drug‐resistant cancer cells that continue proliferating even after mitotic errors, understanding these mechanisms opens the door for new potential therapeutic ...
Cornelia Sala, Elmar Schiebel
wiley   +1 more source