Results 151 to 160 of about 282,951 (269)

Structural insights into anaphase-promoting complex function and mechanism [PDF]

Philosophical Transactions of the Royal Society B: Biological Sciences, 2011
The anaphase-promoting complex or cyclosome (APC/C) controls sister chromatid segregation and the exit from mitosis by catalysing the ubiquitylation of cyclins and other cell cycle regulatory proteins. This unusually large E3 RING-cullin ubiquitin ligase is assembled from 13 different proteins.
openaire   +3 more sources

BUB1B Promotes Ovarian Cancer Cell Proliferation and Metastasis by Activating the Wnt/β‐Catenin Pathway

Cancer Medicine, Volume 14, Issue 21, November 2025.
ABSTRACT Background BUB1 mitotic checkpoint serine/threonine kinase B (BUB1B) has been found to participate in cancer progression. Nevertheless, the function and mechanism of BUB1B in ovarian cancer (OC) remain unknown. Method Based on datasets GSE14407, GSE18520, and the TCGA combined GTEx database, the differently expressed genes (DEGs) between OC ...
Jing Wang, Xiaoling Su, Nan Lin, Tao Su
wiley   +1 more source

Linear ubiquitination of p31comet by HOIP couples cytokine response with mitotic regulation

Cell & Bioscience
Background Inflammation and genomic instability are among the hallmarks of human cancer. Proinflammatory cytokines induce DNA damage through the accumulation of reactive oxygen and nitrogen species (RONS), which often leads to base alternations. The link
Yifeng Gao, Qing Yin, Yaser Gamallat, Michael G. Grant, Aidan H. Snell, Xingxing Shi, Lara N. Ulstad, Arshita Singh, Tingan Chen, Joseph O. Johnson, Dorina Avram, Lixin Wan   +11 more
doaj   +1 more source

CHMP4C: A novel regulator of the mitotic spindle checkpoint

Molecular & Cellular Oncology, 2018
The mitotic spindle checkpoint delays anaphase onset until all chromosomes have achieved stable kinetochore-microtubule attachments. Here, we discuss recent findings showing that CHMP4C, a component of the endosomal sorting complex required for transport
Eleni Petsalaki, George Zachos
doaj   +1 more source

Phosphorylation by Cdc28 Activates the Cdc20-Dependent Activity of the Anaphase-Promoting Complex [PDF]

, 2000
Adam D. Rudner, Andrew W. Murray
openalex   +1 more source

Chromosomal instability and genomic alterations in cholangiocarcinoma from Northeastern Thailand

The Journal of Pathology, Volume 267, Issue 3, Page 261-274, November 2025.
Abstract Cholangiocarcinoma (CCA) is a lethal cancer of the bile duct and is a major health concern in several parts of the world, including northeastern Thailand, where CCA incidence is the highest due to the endemic liver fluke Opisthorchis viverrini.
Raksawan Deenonpoe, Molly A Guscott, Sasithorn Watcharadetwittaya, Isabel L McNeill, Daniela Moralli, Nadeem Shaikh, Sarah E McClelland   +6 more
wiley   +1 more source

The RING-H2 finger protein APC11 and the E2 enzyme UBC4 are sufficient to ubiquitinate substrates of the anaphase-promoting complex [PDF]

, 2000
Michael Gmachl, Christian Gieffers, Alexandre V. Podtelejnikov, Matthias Mann, Jan‐Michael Peters   +4 more
openalex   +1 more source

The checkpoint protein MAD2 and the mitotic regulator CDC20 form a ternary complex with the anaphase-promoting complex to control anaphase initiation.

Genes & Development, 1998
The spindle assembly checkpoint mechanism delays anaphase initiation until all chromosomes are aligned at the metaphase plate. Activation of the anaphase-promoting complex (APC) by binding of CDC20 and CDH1 is required for exit from mitosis, and APC has ...
G. Fang, Hongtao Yu, Hongtao Yu, M. Kirschner   +3 more
semanticscholar   +1 more source

Mcm10 proteolysis initiates before the onset of M-phase

BMC Cell Biology, 2010
Background Mcm10 protein is essential for initiation and elongation phases of replication. Human cells proteolyze Mcm10 during mitosis, presumably to ensure a single round of replication. It has been proposed that anaphase promoting complex ubiquitinates
Khan Muntaz, Sharma Aparna, Kaur Manpreet, Kar Ananya, Saxena Sandeep   +4 more
doaj   +1 more source

The anaphase-promoting complex controls a ubiquitination-phosphoprotein axis in chromatin during neurodevelopment. [PDF]

Dev Cell, 2023
Ledvin L, Gassaway BM, Tawil J, Urso O, Pizzo D, Welsh KA, Bolhuis DL, Fisher D, Bonni A, Gygi SP, Brown NG, Ferguson CJ.   +11 more
europepmc   +1 more source