Results 161 to 170 of about 53,781 (249)

High‐throughput screening identifies a previously undescribed checkpoint controlling mitotic progression in response to DNA damage

The FEBS Journal, Volume 292, Issue 24, Page 6516-6532, December 2025.
DNA damage can slow or delay the cell cycle to allow for DNA repair to occur. However, the mechanism underlying this is unclear. Here, we show that in response to cells entering mitosis with damaged DNA, SOD1 restrains the activity of the phosphatase PP2a activity via oxidation of cysteine residues at PP2a's active site.
Nan Li, Rachel Gatenby, Thomas Walne, Caroline Daye, Steven Watson, Priya Lata, Stephen Brown, Ruth Thompson   +7 more
wiley   +1 more source

Dysfunction of an Anaphase-Promoting Complex Subunit 8 Homolog Leads to Super-Short Petioles and Enlarged Petiole Angles in Soybean. [PDF]

Int J Mol Sci, 2023
Gao Y, Zhu J, Zhai H, Xu K, Zhu X, Wu H, Zhang W, Wu S, Chen X, Xia Z.   +9 more
europepmc   +1 more source

Smad3 recruits the anaphase-promoting complex for ubiquitination and degradation of SnoN [PDF]

, 2001
Shannon L. Stroschein, Shirin Bonni, Jeffrey L. Wrana, Kunxin Luo   +3 more
openalex   +1 more source

DNA damage in mitosis: SOD1 delays anaphase onset

The FEBS Journal, Volume 292, Issue 24, Page 6512-6515, December 2025.
Mitotic cells do not exhibit a DNA damage checkpoint delay and do not repair DNA double strand breaks (DSBs) until the next cell cycle. Instead, DSBs can delay anaphase through the mitotic spindle checkpoint, by an incompletely understood mechanism. Li et al.
George Zachos
wiley   +1 more source

Control of division in Chlamydomonas by cyclin B/CDKB1 and the anaphase-promoting complex. [PDF]

PLoS Genet, 2022
Pecani K, Lieberman K, Tajima-Shirasaki N, Onishi M, Cross FR.   +4 more
europepmc   +1 more source

The Phosphatase-Transcription Activator EYA1 Is Targeted by Anaphase-Promoting Complex/Cdh1 for Degradation at M-to-G₁ Transition [PDF]

, 2012
Jianbo Sun, Zoi Karoulia, Elaine Y.M. Wong, Mohi Ahmed, Keiji Itoh, Pin‐Xian Xu   +5 more
openalex   +1 more source

Time-resolved cryo-EM (TR-EM) analysis of substrate polyubiquitination by the RING E3 anaphase-promoting complex/cyclosome (APC/C). [PDF]

Nat Struct Mol Biol, 2023
Bodrug T, Welsh KA, Bolhuis DL, Paulаkonis E, Martinez-Chacin RC, Liu B, Pinkin N, Bonacci T, Cui L, Xu P, Roscow O, Amann SJ, Grishkovskaya I, Emanuele MJ, Harrison JS, Steimel JP, Hahn KM, Zhang W, Zhong ED, Haselbach D, Brown NG.   +20 more
europepmc   +1 more source

Overexpression of the Anaphase Promoting Complex/Cyclosome Inhibitor Emi1 Leads to Tetraploidy and Genomic Instability of p53-Deficient Cells [PDF]

, 2006
Norman L. Lehman, Emmy W. Verschuren, Jerry Y. Hsu, Athena M. Cherry, Peter K. Jackson   +4 more
openalex   +1 more source

Precocious activation of APC/C-Cdh1 at pre-anaphase causes genome instability [PDF]

, 2008
Faithful chromosome segregation and thereby accurate gene transmission are crucial for all organisms. Until proper attachment of the mitotic spindle to the kinetochore is established, the ubiquitin ligase (E3) Cdc20-activated APC/C (anaphase promoting ...
Asuka Suzuki, Ayumu Yamamoto, Kazuhiro Toda, Masahiro Uritani, Masaru Ueno, Takanori Ohyoshi, Takashi Ushimaru   +6 more
core   +1 more source

Targeting the anaphase-promoting complex/cyclosome (APC/C) enhanced antiproliferative and apoptotic response in bladder cancer. [PDF]

Saudi J Biol Sci, 2023
Sevim Nalkiran H, Akcora Yildiz D, Saydam F, Guzel AI, Nalkiran I.   +4 more
europepmc   +1 more source