Identification of anaphase promoting complex substrates in S. cerevisiae. [PDF]
PLoS ONE, 2012 The Anaphase-Promoting Complex/Cyclosome (APC/C) is an essential ubiquitin ligase that targets numerous proteins for proteasome-mediated degradation in mitosis and G1. To gain further insight into cellular pathways controlled by APC/C(Cdh1), we developed
Denis Ostapenko +2 more
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The Plant Anaphase-Promoting Complex/Cyclosome [PDF]
Annual Review of Cell and Developmental Biology, 2022 The anaphase-promoting complex/cyclosome (APC/C) represents a large multisubunit E3-ubiquitin ligase complex that controls the unidirectional progression through the cell cycle by the ubiquitination of specific target proteins, marking them for proteasomal destruction.
Alex Willems, Lieven De Veylder
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Peptide inhibitors of the anaphase promoting-complex that cause sensitivity to microtubule poison. [PDF]
PLoS ONE, 2018 There is an interest in identifying Anaphase Promoting-Complex/Cyclosome (APC/C) inhibitors that lead to sensitivity to microtubule poisons as a strategy for targeting cancer cells.
Scott C Schuyler +13 more
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Bifidobacterium infantis Maintains Genome Stability in Ulcerative Colitis via Regulating Anaphase-Promoting Complex Subunit 7. [PDF]
Front Microbiol, 2021 Han T +5 more
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A comparative study of the cryo-EM structures of S. cerevisiae and human anaphase-promoting complex/cyclosome (APC/C) [PDF]
Vazquez-Fernandez E +5 more
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The role of Anaphase Promoting Complex activation, inhibition and substrates in cancer development and progression. [PDF]
Aging (Albany NY), 2020 VanGenderen C, Harkness TAA, Arnason TG.
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APC/C-Cdh1-targeted substrates as potential therapies for Alzheimer’s disease
Frontiers in Pharmacology, 2022 Alzheimer’s disease (AD) is the most prevalent neurodegenerative disorder and the main cause of dementia in the elderly. The disease has a high impact on individuals and their families and represents a growing public health and socio-economic burden ...
Rebeca Lapresa +7 more
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Ubc1 turnover contributes to the spindle assembly checkpoint in Saccharomyces cerevisiae
G3: Genes, Genomes, Genetics, 2021 The spindle assembly checkpoint protects the integrity of the genome by ensuring that chromosomes are properly attached to the mitotic spindle before they are segregated during anaphase.
Heather E Arsenault +8 more
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Anaphase Promoting Complex or Cyclosome? [PDF]
Cell Cycle, 2005 The anaphase promoting complex/cyclosome (APC/C) was initially described as a multi-subunit protein complex that ubiquitinates anaphase inhibitors thus targeting them for destruction by proteasomes to initiate loss of sister chromatid cohesion. However, recent studies have identified important new functions of the APC/C.
Duncan J, Clarke +2 more
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