Identification of anaphase promoting complex substrates in S. cerevisiae. [PDF]
PLoS ONE, 2012 The Anaphase-Promoting Complex/Cyclosome (APC/C) is an essential ubiquitin ligase that targets numerous proteins for proteasome-mediated degradation in mitosis and G1. To gain further insight into cellular pathways controlled by APC/C(Cdh1), we developed
Denis Ostapenko +2 more
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A decade of the anaphase-promoting complex in the nervous system [PDF]
Genes & Development, 2016 Control of protein abundance by the ubiquitin–proteasome system is essential for normal brain development and function. Just over a decade ago, the first post-mitotic function of the anaphase-promoting complex, a major cell cycle-regulated E3 ubiquitin ...
Bonni, Azad, Huang, Ju
core +6 more sources
The role of the anaphase-promoting complex/cyclosome in plant growth [PDF]
Critical Reviews in Plant Sciences, 2015 The anaphase-promoting complex/cyclosome (APC/C) is a multi-subunit E3 ubiquitin ligase that plays a major role in the progression of the eukaryotic cell cycle.
de Freitas Lima, Marcelo +3 more
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The Anaphase Promoting Complex/Cyclosome Subunit 11 and Its Role in Organ Size and Plant Development. [PDF]
Front Plant Sci, 2021 Schwedersky RP +6 more
europepmc +2 more sources
Lactate: A critical regulator of cell proliferation via anaphase promoting complex remodeling [PDF]
MedComm – Oncology, 2023 Qiqing Yang, Long Zhang, Jun Chen
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Proximity Labeling Reveals Spatial Regulation of the Anaphase-Promoting Complex/Cyclosome by a Microtubule Adaptor. [PDF]
ACS Chem Biol, 2022 Cao X +4 more
europepmc +3 more sources
Peptide inhibitors of the anaphase promoting-complex that cause sensitivity to microtubule poison. [PDF]
PLoS ONE, 2018 There is an interest in identifying Anaphase Promoting-Complex/Cyclosome (APC/C) inhibitors that lead to sensitivity to microtubule poisons as a strategy for targeting cancer cells.
Scott C Schuyler +13 more
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APC/C-Cdh1-targeted substrates as potential therapies for Alzheimer’s disease
Frontiers in Pharmacology, 2022 Alzheimer’s disease (AD) is the most prevalent neurodegenerative disorder and the main cause of dementia in the elderly. The disease has a high impact on individuals and their families and represents a growing public health and socio-economic burden ...
Rebeca Lapresa +7 more
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The Plant Anaphase-Promoting Complex/Cyclosome
Annual Review of Cell and Developmental Biology, 2022 The anaphase-promoting complex/cyclosome (APC/C) represents a large multisubunit E3-ubiquitin ligase complex that controls the unidirectional progression through the cell cycle by the ubiquitination of specific target proteins, marking them for proteasomal destruction.
Willems, Alex, De Veylder, Lieven
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Anaphase Promoting Complex or Cyclosome? [PDF]
Cell Cycle, 2005 The anaphase promoting complex/cyclosome (APC/C) was initially described as a multi-subunit protein complex that ubiquitinates anaphase inhibitors thus targeting them for destruction by proteasomes to initiate loss of sister chromatid cohesion. However, recent studies have identified important new functions of the APC/C.
Duncan J, Clarke +2 more
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