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The anaphase promoting complex.
Cancer surveys, 1997We have proposed a preliminary model of how the anaphase promoting complex functions throughout the cell cycle, but despite the flurry of recent publications characterizing the APC--its components, regulation and substrate specificity--many fundamental questions remain to be answered.
A M, Page, P, Hieter
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Subunits and Substrates of the Anaphase-Promoting Complex
Experimental Cell Research, 1999The initiation of anaphase and exit from mitosis depend on a ubiquitination complex called the anaphase-promoting complex (APC) or cyclosome. The APC is composed of more than 10 constitutive subunits and associates with additional regulatory factors in mitosis and during the G1 phase of the cell cycle.
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Anaphase‐promoting complex/cyclosome‐Cdc‐20 promotes Zwint‐1 degradation
Cell Biochemistry and Function, 2020ZW10 interactor (Zwint‐1) is an important component of the centromere and can recruit the dynamic protein kinase and dynein to promote chromosome movement and regulate the spindle assembly checkpoint (SAC). Zwint‐1 activity is tightly regulated during the cell cycle. However, how the stability of Zwint‐1 is regulated has not been clarified.
Yan He +7 more
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Regulation of Anaphase Promoting Complex Coactivators
2010Ubiquitin-mediated proteolytic degradation is fundamental to eukaryotic cell cycle progression. From late mitosis through early G1, the Anaphase Promoting Complex (APC) is essential for cell-cycle relevant proteolytic degradation, and its activity is targeted to appropriate substrates by the evolutionarily conserved coactivators Cdc20 and Cdh1.
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Anaphase-Promoting Complex Control in Female Mouse Meiosis
2011Entry into, and passage through, the two meiotic divisions of the oocyte has to be highly coordinated to ensure proper segregation of chromosomes. This coordination ensures that the hallmark stops and starts of the meiotic process occur at the right time to prevent aneuploidy.
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Regulation of the anaphase-promoting complex by phosphorylation
2007Regulation of the eukaryotic cell cycle is accomplished in large part by well-timed and targeted destruction of proteins that inhibit or activate passage through cell cycle transitions. Ubiquitin-mediated proteolysis is well established as the primary mechanism through which this occurs, and the anaphase-promoting complex (APC), an E3 ubiquitin ligase,
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