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Correction: A Minimal Anaphase Promoting Complex/Cyclosome (APC/C) in Trypanosoma brucei
PLoS ONE, 2013 doaj
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The anaphase promoting complex/cyclosome: a machine designed to destroy
Nature Reviews Molecular Cell Biology, 2006The anaphase promoting complex/cyclosome (APC/C) is a ubiquitin ligase that has essential functions in and outside the eukaryotic cell cycle. It is the most complex molecular machine that is known to catalyse ubiquitylation reactions, and it contains more than a dozen subunits that assemble into a large 1.5-MDa complex. Recent discoveries have revealed
J. Peters
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Genes, Chromosomes and Cancer, 2020
The anaphase‐promoting complex/cyclosome (APC/C) is an E3 ubiquitin ligase that helps control chromosome separation and exit from mitosis in many different kinds of organisms, including yeast, flies, worms, and humans.
P. Melloy
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The anaphase‐promoting complex/cyclosome (APC/C) is an E3 ubiquitin ligase that helps control chromosome separation and exit from mitosis in many different kinds of organisms, including yeast, flies, worms, and humans.
P. Melloy
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Mitotic regulation of the anaphase-promoting complex
Cellular and Molecular Life Sciences, 2007Orderly progression through mitosis is regulated by the anaphase-promoting complex/cyclosome (APC/C), a large multiprotein E3 ubiquitin ligase that targets key mitotic regulators for destruction by the proteasome. APC/C has two activating subunits, Cdc20 and Cdh1. The well-established view is that Cdc20 activates APC/C from the onset of mitosis through
Paul J. Galardy +3 more
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Identification of BIME as a Subunit of the Anaphase-Promoting Complex [PDF]
Science, 1996 The initiation of anaphase and exit from mitosis require the activation of a proteolytic system that ubiquitinates and degrades cyclin B. The regulated component of this system is a large ubiquitin ligase complex, termed the anaphase-promoting complex (APC) or cyclosome.
Jan-Michael Peters +3 more
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Enzymology of the Anaphase‐Promoting Complex
2005The anaphase-promoting complex (APC) is an ubiquitin-protein ligase that promotes mitotic progression by catalyzing the ubiquitination of numerous proteins, including securin and cyclin. Its complex subunit composition and extensive regulation make the APC an active subject of investigation for both cell biologists and enzymologists.
David O. Morgan, Christopher W. Carroll
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Non-mitotic functions of the Anaphase-Promoting Complex
Seminars in Cell & Developmental Biology, 2011The Anaphase-Promoting Complex or Cyclosome (APC/C) is an E3 ubiquitin ligase whose activation requires the binding of a cofactor, either Cdc20 or Cdh1. While APC/C-Cdc20 is a major player during mitotic exit, APC/C-Cdh1 plays a central role in maintaining quiescence and controlling the onset of DNA replication. In addition, APC/C-Cdh1 is essential for
Marcos Malumbres +2 more
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Subunits and Substrates of the Anaphase-Promoting Complex
Experimental Cell Research, 1999The initiation of anaphase and exit from mitosis depend on a ubiquitination complex called the anaphase-promoting complex (APC) or cyclosome. The APC is composed of more than 10 constitutive subunits and associates with additional regulatory factors in mitosis and during the G1 phase of the cell cycle.
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A role for the anaphase promoting complex in hormone regulation
Planta, 2011To increase our knowledge of anaphase promoting complex (APC/C) function during plant development, we characterized an Arabidopsis thaliana T-DNA-insertion line where the T-DNA fell within the 5' regulatory region of the APC10 gene. The insert disrupted endogenous expression, resulting in overexpression of APC10 mRNA from the T-DNA- internal CaMV 35S ...
Troy A. A. Harkness +4 more
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