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The Anaphase-Promoting Complex: New Subunits and Regulators
Annual Review of Biochemistry, 1999▪ Abstract Ubiquitin-mediated proteolysis of cell cycle regulators is a crucial process during the cell cycle. The anaphase-promoting complex (APC) is a large, multiprotein complex whose E3-ubiquitin ligase activity is required for the ubiquitination of mitotic cyclins and other regulatory proteins that are targeted for destruction during cell ...
Philip Hieter, A M Page
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The Doc1 subunit is a processivity factor for the anaphase-promoting complex
Nature Cell Biology, 2002Ubiquitin-mediated proteolysis of securin and mitotic cyclins is essential for exit from mitosis. The final step in ubiquitination of these and other proteins is catalysed by the anaphase-promoting complex (APC), a multi-subunit ubiquitin-protein ligase (E3).
David O. Morgan, Christopher W. Carroll
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Anaphase-Promoting Complex / Cyclosome
RCSB Protein Data Bank, 2023D. Goodsell
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Anaphase-Promoting Complex Control in Female Mouse Meiosis
2011Entry into, and passage through, the two meiotic divisions of the oocyte has to be highly coordinated to ensure proper segregation of chromosomes. This coordination ensures that the hallmark stops and starts of the meiotic process occur at the right time to prevent aneuploidy.
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The anaphase-promoting complex (APC): the sum of its parts?
Biochemical Society Transactions, 2004The APC (anaphase-promoting complex) is a multisubunit E3 ubiquitin ligase that targets cell-cycle-related proteins for degradation by the 26 S proteasome. The APC contains at least 13 subunits and is regulated by the binding of co-activator proteins and by phosphorylation.
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Insights into the anaphase-promoting complex: a molecular machine that regulates mitosis.
Current Opinion in Structural Biology, 2014Leifu Chang, D. Barford
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The Anaphase Promoting Complex and Aging: The APCs of Longevity
Current Genomics, 2006openaire +2 more sources