Results 21 to 30 of about 54,411 (234)
NIR is degraded by the anaphase-promoting complex proteasome pathway [PDF]
Archives of Biological Sciences, 2014 Novel INHAT Repressor (NIR) is a histone acetylation inhibitor that can directly bind histone complexes and the tumor suppressors p53 and p63.
Jeong Ho Myong +3 more
doaj +1 more source
A novel function of anaphase promoting complex subunit 10 in tumor progression in non-small cell lung cancer. [PDF]
Cell Cycle, 2019 Wang Y +9 more
europepmc +3 more sources
Nature Communications, 2020 The spindle assembly checkpoint (SAC) safeguards chromosome segregation by regulating the anaphase promoting complex/cyclosome (APC/C), allowing chromosomes to correctly attach to mitotic spindles. Here the authors reveal a role for Cullin–RING ubiquitin
Sang-Min Jang +12 more
doaj +1 more source
A decade of the anaphase-promoting complex in the nervous system [PDF]
, 2016 Control of protein abundance by the ubiquitin–proteasome system is essential for normal brain development and function. Just over a decade ago, the first post-mitotic function of the anaphase-promoting complex, a major cell cycle-regulated E3 ubiquitin ...
Bonni, Azad, Huang, Ju
core +2 more sources
Biology Open, 2014 The Anaphase Promoting Complex or Cyclosome (APC/C) is critical to the control of mitosis. The APC/C is an ubiquitin ligase that targets specific mitotic regulators for proteolysis at distinct times in mitosis, but how this is achieved is not well ...
Takahiro Matsusaka +3 more
doaj +1 more source
Phosphorylation of MCPH1 isoforms during mitosis followed by isoform‐specific degradation by APC/C‐CDH1 [PDF]
, 2019 Microcephalin‐1 (MCPH1) exists as 2 isoforms that regulate cyclin‐dependent kinase‐1 activation and chromosome condensation during mitosis, with MCPH1 mutations causing primary microcephaly.
Blain, Peter G. +5 more
core +2 more sources
Frontiers in Cellular Neuroscience, 2017 Neonatal exposure to isoflurane can result in neuroapoptosis and persistent cognitive impairments. However, the underlying mechanisms remain elusive. Anaphase-promoting complex/cyclosome (APC/C) and its co-activator Cdh1 are E3 ubiquitin ligases that ...
Xuan Li +7 more
doaj +1 more source
The meiosis-specific Cdc20 family-member Ama1 promotes binding of the Ssp2 activator to the Smk1 MAP kinase. [PDF]
, 2018 Smk1 is a meiosis-specific MAP kinase (MAPK) in budding yeast that is required for spore formation. It is localized to prospore membranes (PSMs), the structures that engulf haploid cells during meiosis II (MII).
Diamond, Aviva +5 more
core +3 more sources
The anaphase-promoting complex/cyclosome: APC/C [PDF]
Journal of Cell Science, 2006 The major ubiquitin ligase required for mitosis is the anaphase-promoting complex/cyclosome (APC/C). This unusually complex E3 ubiquitin ligase targets cell-cycle-related proteins such as cyclins and securin for degradation by the proteasome in mitosis and meiosis.
Claire, Acquaviva, Jonathon, Pines
openaire +2 more sources
BMC Evolutionary Biology, 2011 Background The Anaphase Promoting Complex or Cyclosome (APC/C) is the largest member of the ubiquitin ligase [E3] family. It plays a crucial role in the control of the cell cycle and cell proliferation by mediating the proteolysis of key components by ...
Brochier-Armanet Céline +3 more
doaj +1 more source