The anaphase-promoting complex regulates the degradation of the inner nuclear membrane protein Mps3. [PDF]
J Cell Biol, 2019 The nucleus is enclosed by the inner nuclear membrane (INM) and the outer nuclear membrane (ONM). While the ONM is continuous with the endoplasmic reticulum (ER), the INM is independent and separates the nucleoplasm from the ER lumen.
Koch BA, Jin H, Tomko RJ, Yu HG.
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Activating the Anaphase Promoting Complex to Enhance Genomic Stability and Prolong Lifespan. [PDF]
Int J Mol Sci, 2018 In aging cells, genomic instability is now recognized as a hallmark event. Throughout life, cells encounter multiple endogenous and exogenous DNA damaging events that are mostly repaired, but inevitably DNA mutations, chromosome rearrangements, and ...
Harkness TAA.
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Three-Dimensional Structure of the Anaphase-Promoting Complex [PDF]
Molecular Cell, 2001 The anaphase-promoting complex (APC) is a cell cycle-regulated ubiquitin-protein ligase, composed of at least 11 subunits, that controls progression through mitosis and G1. Using cryo-electron microscopy and angular reconstitution, we have obtained a three-dimensional model of the human APC at a resolution of 24 A.
Christian Gieffers +4 more
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Peptide inhibitors of the anaphase promoting-complex that cause sensitivity to microtubule poison. [PDF]
PLoS ONE, 2018 There is an interest in identifying Anaphase Promoting-Complex/Cyclosome (APC/C) inhibitors that lead to sensitivity to microtubule poisons as a strategy for targeting cancer cells.
Scott C Schuyler +13 more
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Genomic evolution and complexity of the Anaphase-promoting Complex (APC) in land plants [PDF]
BMC Plant Biology, 2010 Background The orderly progression through mitosis is regulated by the Anaphase-Promoting Complex (APC), a large multiprotein E3 ubiquitin ligase that targets key cell-cycle regulators for destruction by the 26 S proteasome.
Hemerly Adriana S +10 more
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Spatiotemporal regulation of the anaphase-promoting complex in mitosis [PDF]
Nature Reviews Molecular Cell Biology, 2015 The appropriate timing of events that lead to chromosome segregation during mitosis and cytokinesis is essential to prevent aneuploidy, and defects in these processes can contribute to tumorigenesis. Key mitotic regulators are controlled through ubiquitylation and proteasome-mediated degradation. The APC/C (anaphase-promoting complex; also known as the
Sushama Sivakumar, G. Gorbsky
semanticscholar +4 more sources
Mutations in ANAPC1, Encoding a Scaffold Subunit of the Anaphase-Promoting Complex, Cause Rothmund-Thomson Syndrome Type 1. [PDF]
Am J Hum Genet, 2019 Ajeawung NF +13 more
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The anaphase-promoting complex: proteolysis in mitosis and beyond. [PDF]
Molecular Cell, 2002 Key events in mitosis such as sister chromatid separation and subsequent inactivation of cyclin-dependent kinase 1 are regulated by ubiquitin-dependent proteolysis. These events are mediated by the anaphase-promoting complex (APC), a cell cycle-regulated ubiquitin ligase that assembles multiubiquitin chains on regulatory proteins such as securin and ...
J. Peters
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The Anaphase-Promoting Complex/Cyclosome Is a Cellular Ageing Regulator. [PDF]
Int J Mol Sci, 2022 The anaphase-promoting complex/cyclosome (APC/C) is a complicated cellular component that plays significant roles in regulating the cell cycle process of eukaryotic organisms. The spatiotemporal regulation mechanisms of APC/C in distinct cell cycle transitions are no longer mysterious, and the components of this protein complex are gradually identified
Hu X, Jin X, Cao X, Liu B.
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APC/C-Cdh1-targeted substrates as potential therapies for Alzheimer’s disease
Frontiers in Pharmacology, 2022 Alzheimer’s disease (AD) is the most prevalent neurodegenerative disorder and the main cause of dementia in the elderly. The disease has a high impact on individuals and their families and represents a growing public health and socio-economic burden ...
Rebeca Lapresa +7 more
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