Results 21 to 30 of about 53,781 (249)
Ubc1 turnover contributes to the spindle assembly checkpoint in Saccharomyces cerevisiae
G3: Genes, Genomes, Genetics, 2021 The spindle assembly checkpoint protects the integrity of the genome by ensuring that chromosomes are properly attached to the mitotic spindle before they are segregated during anaphase.
Heather E Arsenault +8 more
doaj +1 more source
A novel function of anaphase promoting complex subunit 10 in tumor progression in non-small cell lung cancer. [PDF]
Cell Cycle, 2019 Wang Y +9 more
europepmc +3 more sources
NIR is degraded by the anaphase-promoting complex proteasome pathway [PDF]
Archives of Biological Sciences, 2014 Novel INHAT Repressor (NIR) is a histone acetylation inhibitor that can directly bind histone complexes and the tumor suppressors p53 and p63.
Jeong Ho Myong +3 more
doaj +1 more source
Regulation of the anaphase-promoting complex by phosphorylation
, 2019 Regulation of the eukaryotic cell cycle is accomplished in large part by well-timed and targeted destruction of proteins that inhibit or activate passage through cell cycle transitions. Ubiquitin-mediated proteolysis is well established as the primary mechanism through which this occurs, and the anaphase-promoting complex (APC), an E3 ubiquitin ligase,
Matthew P. Torres
openalex +3 more sources
An architectural map of the anaphase-promoting complex [PDF]
Genes & Development, 2006 The anaphase-promoting complex or cyclosome (APC) is an unusually complicated ubiquitin ligase, composed of 13 core subunits and either of two loosely associated regulatory subunits, Cdc20 and Cdh1. We analyzed the architecture of the APC using a recently constructed budding yeast strain that is viable in the absence of normally essential APC subunits.
Brian R, Thornton +5 more
openaire +2 more sources
MAD2B is an inhibitor of the anaphase-promoting complex [PDF]
Genes & Development, 2001 Anaphase-promoting complex (APC), a ubiquitin ligase, controls both sister chromatid separation and mitotic exit. The APC is activated in mitosis and G1 by CDC20 and CDH1, and inhibited by the checkpoint protein MAD2, a specific inhibitor of CDC20. We show here that a MAD2 homolog MAD2B also inhibits APC.
J, Chen, G, Fang
openaire +2 more sources
Nature Communications, 2020 The spindle assembly checkpoint (SAC) safeguards chromosome segregation by regulating the anaphase promoting complex/cyclosome (APC/C), allowing chromosomes to correctly attach to mitotic spindles. Here the authors reveal a role for Cullin–RING ubiquitin
Sang-Min Jang +12 more
doaj +1 more source
Three-Dimensional Structure of the Anaphase-Promoting Complex [PDF]
Molecular Cell, 2001 The anaphase-promoting complex (APC) is a cell cycle-regulated ubiquitin-protein ligase, composed of at least 11 subunits, that controls progression through mitosis and G1. Using cryo-electron microscopy and angular reconstitution, we have obtained a three-dimensional model of the human APC at a resolution of 24 A.
Gieffers, C. +4 more
openaire +4 more sources
Biology Open, 2014 The Anaphase Promoting Complex or Cyclosome (APC/C) is critical to the control of mitosis. The APC/C is an ubiquitin ligase that targets specific mitotic regulators for proteolysis at distinct times in mitosis, but how this is achieved is not well ...
Takahiro Matsusaka +3 more
doaj +1 more source
Phosphorylation of MCPH1 isoforms during mitosis followed by isoform‐specific degradation by APC/C‐CDH1 [PDF]
, 2019 Microcephalin‐1 (MCPH1) exists as 2 isoforms that regulate cyclin‐dependent kinase‐1 activation and chromosome condensation during mitosis, with MCPH1 mutations causing primary microcephaly.
Blain, Peter G. +5 more
core +2 more sources