Results 31 to 40 of about 282,951 (269)
Anaphase Promoting Complex or Cyclosome? [PDF]
Cell Cycle, 2005 The anaphase promoting complex/cyclosome (APC/C) was initially described as a multi-subunit protein complex that ubiquitinates anaphase inhibitors thus targeting them for destruction by proteasomes to initiate loss of sister chromatid cohesion. However, recent studies have identified important new functions of the APC/C.
Duncan J. Clarke +2 more
openaire +3 more sources
Molecular architecture and mechanism of the anaphase-promoting complex [PDF]
Nature, 2014 The ubiquitination of cell cycle regulatory proteins by the anaphase-promoting complex/cyclosome (APC/C) controls sister chromatid segregation, cytokinesis and the establishment of the G1 phase of the cell cycle. The APC/C is an unusually large multimeric cullin-RING ligase.
Leifu Chang +4 more
semanticscholar +4 more sources
Ubc1 turnover contributes to the spindle assembly checkpoint in Saccharomyces cerevisiae
G3: Genes, Genomes, Genetics, 2021 The spindle assembly checkpoint protects the integrity of the genome by ensuring that chromosomes are properly attached to the mitotic spindle before they are segregated during anaphase.
Heather E Arsenault +8 more
doaj +1 more source
An architectural map of the anaphase-promoting complex [PDF]
Genes & Development, 2006 The anaphase-promoting complex or cyclosome (APC) is an unusually complicated ubiquitin ligase, composed of 13 core subunits and either of two loosely associated regulatory subunits, Cdc20 and Cdh1. We analyzed the architecture of the APC using a recently constructed budding yeast strain that is viable in the absence of normally essential APC subunits.
Mary E. Matyskiela +5 more
openaire +3 more sources
MAD2B is an inhibitor of the anaphase-promoting complex [PDF]
Genes & Development, 2001 Anaphase-promoting complex (APC), a ubiquitin ligase, controls both sister chromatid separation and mitotic exit. The APC is activated in mitosis and G1 by CDC20 and CDH1, and inhibited by the checkpoint protein MAD2, a specific inhibitor of CDC20. We show here that a MAD2 homolog MAD2B also inhibits APC.
Guowei Fang, James Chen
openaire +3 more sources
Mechanisms of ubiquitin transfer by the anaphase-promoting complex [PDF]
Journal of Biology, 2009 The anaphase-promoting complex (APC) is a ubiquitin-protein ligase required for the completion of mitosis in all eukaryotes. Recent mechanistic studies reveal how this remarkable enzyme combines specificity in substrate binding with flexibility in ubiquitin transfer, thereby allowing the modification of multiple lysines on the substrate as well as ...
Matyskiela, Mary E +2 more
openaire +5 more sources
Mitotic regulation of the human anaphase-promoting complex by phosphorylation [PDF]
The EMBO Journal, 2003 The anaphase-promoting complex (APC) or cyclosome is a ubiquitin ligase that initiates anaphase and mitotic exit. APC activation is thought to depend on APC phosphorylation and Cdc20 binding. We have identified 43 phospho-sites on APC of which at least 34 are mitosis specific.
Casey T. Kraft
openalex +6 more sources
NIR is degraded by the anaphase-promoting complex proteasome pathway [PDF]
Archives of Biological Sciences, 2014 Novel INHAT Repressor (NIR) is a histone acetylation inhibitor that can directly bind histone complexes and the tumor suppressors p53 and p63.
Jeong Ho Myong +3 more
doaj +1 more source
Regulation of the anaphase-promoting complex by the COP9 signalosome [PDF]
Cell Cycle, 2009 The COP9 complex (signalosome) is a known regulator of the proteasome/ubiquitin pathway. Furthermore it regulates the activity of the cullin-RING ligase (CRL) families of ubiquitin E3-complexes. Besides the CRL family, the anaphase-promoting complex (APC/C) is a major regulator of the cell cycle.
Robert Kob +5 more
openaire +3 more sources
Nature Communications, 2020 The spindle assembly checkpoint (SAC) safeguards chromosome segregation by regulating the anaphase promoting complex/cyclosome (APC/C), allowing chromosomes to correctly attach to mitotic spindles. Here the authors reveal a role for Cullin–RING ubiquitin
Sang-Min Jang +12 more
doaj +1 more source