Results 41 to 50 of about 53,781 (249)
Control of mitotic transitions by the anaphase–promoting complex [PDF]
Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences, 1999 Proteolysis controls key transitions at several points in the cell cycle. In mitosis, the activation of a large ubiquitin–protein ligase, the anaphase–promoting complex (APC), is required for anaphase initiation and for exit from mitosis. We show that APC is under complex control by a network of regulatory factors, CDC20, CDH1 and MAD2.
G, Fang, H, Yu, M W, Kirschner
openaire +2 more sources
Separase prevents genomic instability by controlling replication fork speed [PDF]
, 2016 Proper chromosome segregation is crucial for preserving genomic integrity, and errors in this process cause chromosome mis-segregation, which may contribute to cancer development.
Cucco, Francesco +11 more
core +6 more sources
A minimal anaphase promoting complex/cyclosome (APC/C) in Trypanosoma brucei. [PDF]
PLoS ONE, 2013 The anaphase-promoting complex/cyclosome (APC/C) is a multi-subunit E3 ubiquitin ligase that initiates chromosome segregation and mitotic exit by targeting critical cell-cycle regulators for proteolytic destruction.
Mohamed Bessat +3 more
doaj +1 more source
Novel regulation of mitotic exit by the Cdc42 effectors Gic1 and Gic2 [PDF]
, 2004 Copyright @ The Rockefeller University PressThe guanine nucleotide exchange factor Cdc24, the GTPase Cdc42, and the Cdc42 effectors Cla4 and Ste20, two p21-activated kinases, form a signal transduction cascade that promotes mitotic exit in yeast.
Höfken, T, Schiebel, E
core +2 more sources
Haematologica, 2013 Spindle poison-based therapy is of only limited benefit in acute myeloid leukemia while lymphoblastic leukemia/lymphoma responds well. In this study, we demonstrated that the spindle assembly checkpoint protein BubR1 was down-regulated in the vast ...
Dominik Schnerch +7 more
doaj +1 more source
Mad2, Bub3, and Mps1 regulate chromosome segregation and mitotic synchrony in Giardia intestinalis, a binucleate protist lacking an anaphase-promoting complex. [PDF]
, 2014 The binucleate pathogen Giardia intestinalis is a highly divergent eukaryote with a semiopen mitosis, lacking an anaphase-promoting complex/cyclosome (APC/C) and many of the mitotic checkpoint complex (MCC) proteins.
Cande, W Zacheus, Vicente, Juan-Jesus
core +2 more sources
Visualizing the complex functions and mechanisms of the anaphase promoting complex/cyclosome (APC/C) [PDF]
Open Biology, 2017 The anaphase promoting complex or cyclosome (APC/C) is a large multi-subunit E3 ubiquitin ligase that orchestrates cell cycle progression by mediating the degradation of important cell cycle regulators.
Claudio Alfieri +2 more
doaj +1 more source
Transferring an optimized TAP-toolbox for the isolation of protein complexes to a portfolio of rice tissues [PDF]
, 2016 Proteins are the cell's functional entities. Rather than operating independently, they interact with other proteins. Capturing in vivo protein complexes is therefore crucial to gain understanding of the function of a protein in a cellular context ...
Cannoot, Bernard +12 more
core +1 more source
The anaphase-promoting complex/cyclosome: APC/C [PDF]
Journal of Cell Science, 2006 The major ubiquitin ligase required for mitosis is the anaphase-promoting complex/cyclosome (APC/C). This unusually complex E3 ubiquitin ligase targets cell-cycle-related proteins such as cyclins and securin for degradation by the proteasome in mitosis and meiosis.
Claire, Acquaviva, Jonathon, Pines
openaire +2 more sources
Advanced Biomedical Research, 2017 Background: Anaphase promoting complex (APC) is the biggest Cullin-RING E3 ligase and is very important in cell cycle control; many anti-cancer agents target this.
Hamzeh Rahimi +5 more
doaj +1 more source