Results 41 to 50 of about 282,951 (269)

Inhibition of the anaphase-promoting complex by the Xnf7 ubiquitin ligase [PDF]

The Journal of Cell Biology, 2005
Degradation of specific protein substrates by the anaphase-promoting complex/cyclosome (APC) is critical for mitotic exit. We have identified the protein Xenopus nuclear factor 7 (Xnf7) as a novel APC inhibitor able to regulate the timing of exit from mitosis.
Jessica B. Casaletto, Leta K. Nutt, Qiju Wu, Jonathan D. Moore, Laurence D. Etkin, Peter K. Jackson, Tim Hunt, Sally Kornbluth   +7 more
openalex   +4 more sources

Control of mitotic transitions by the anaphase–promoting complex [PDF]

Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences, 1999
Proteolysis controls key transitions at several points in the cell cycle. In mitosis, the activation of a large ubiquitin–protein ligase, the anaphase–promoting complex (APC), is required for anaphase initiation and for exit from mitosis. We show that APC is under complex control by a network of regulatory factors, CDC20, CDH1 and MAD2.
Guowei Fang, Hongtao Yu, Hongtao Yu, Marc W. Kirschner   +3 more
openaire   +3 more sources

Co-activator independent differences in how the metaphase and anaphase APC/C recognise the same substrate

Biology Open, 2014
The Anaphase Promoting Complex or Cyclosome (APC/C) is critical to the control of mitosis. The APC/C is an ubiquitin ligase that targets specific mitotic regulators for proteolysis at distinct times in mitosis, but how this is achieved is not well ...
Takahiro Matsusaka, Maria Enquist-Newman, David O. Morgan, Jonathon Pines   +3 more
doaj   +1 more source

Phosphorylation of MCPH1 isoforms during mitosis followed by isoform‐specific degradation by APC/C‐CDH1 [PDF]

, 2019
Microcephalin‐1 (MCPH1) exists as 2 isoforms that regulate cyclin‐dependent kinase‐1 activation and chromosome condensation during mitosis, with MCPH1 mutations causing primary microcephaly.
Blain, Peter G., Dunn, Michael, Jowsey, Paul, Meyer, Stephanie K., Porter, Andrew, Vidier, Daniel S.   +5 more
core   +2 more sources

Upregulation of Cdh1 Attenuates Isoflurane-Induced Neuronal Apoptosis and Long-Term Cognitive Impairments in Developing Rats

Frontiers in Cellular Neuroscience, 2017
Neonatal exposure to isoflurane can result in neuroapoptosis and persistent cognitive impairments. However, the underlying mechanisms remain elusive. Anaphase-promoting complex/cyclosome (APC/C) and its co-activator Cdh1 are E3 ubiquitin ligases that ...
Xuan Li, Kai Wei, Rong Hu, Bo Zhang, Li Li, Li Wan, Chuanhan Zhang, Wenlong Yao   +7 more
doaj   +1 more source

The meiosis-specific Cdc20 family-member Ama1 promotes binding of the Ssp2 activator to the Smk1 MAP kinase. [PDF]

, 2018
Smk1 is a meiosis-specific MAP kinase (MAPK) in budding yeast that is required for spore formation. It is localized to prospore membranes (PSMs), the structures that engulf haploid cells during meiosis II (MII).
Diamond, Aviva, Neiman, Aaron M., Omerza, Gregory, Philips, Timothy, Tio, Chong Wai, Winter, Edward   +5 more
core   +3 more sources

The phylogenomic analysis of the anaphase promoting complex and its targets points to complex and modern-like control of the cell cycle in the last common ancestor of eukaryotes

BMC Evolutionary Biology, 2011
Background The Anaphase Promoting Complex or Cyclosome (APC/C) is the largest member of the ubiquitin ligase [E3] family. It plays a crucial role in the control of the cell cycle and cell proliferation by mediating the proteolysis of key components by ...
Brochier-Armanet Céline, Moreira David, Trilles Aurélie, Eme Laura   +3 more
doaj   +1 more source

The anaphase-promoting complex/cyclosome: APC/C [PDF]

Journal of Cell Science, 2006
The major ubiquitin ligase required for mitosis is the anaphase-promoting complex/cyclosome (APC/C). This unusually complex E3 ubiquitin ligase targets cell-cycle-related proteins such as cyclins and securin for degradation by the proteasome in mitosis and meiosis.
Claire Acquaviva, Jonathon Pines
openaire   +3 more sources

Mutations in CCNB3 affect its location thus causing a multiplicity of phenotypes in human oocytes maturation by aberrant CDK1 activity and APC/C activity at different stages

Journal of Ovarian Research, 2023
Background Oocyte maturation arrest results in female infertility and the genetic etiology of this phenotype remains largely unknown. Previous studies have proven that cyclins play a significant role in the cell cycle both in meiosis and mitosis.
Congjing Wang, Meng Xi Chen, Yuan Zhang, Xue Bai, Qiqi Cao, Jian Han, Nana Zhang, Chun Zhao, Xiufeng Ling, Ximan Rui, Yichun Guan, Junqiang Zhang, Ran Huo   +12 more
doaj   +1 more source

APC16 is a conserved subunit of the anaphase-promoting complex/cyclosome [PDF]

Journal of Cell Science, 2015
Error-free chromosome segregation depends on timely activation of the multi-subunit E3 ubiquitin ligase APC/C. Activation of the APC/C initiates chromosome segregation and mitotic exit by targeting critical cell-cycle regulators for destruction. The APC/C is the principle target of the mitotic checkpoint, which prevents segregation while chromosomes ...
G. Kops, Monique van der Voet, Michael S. Manak, M. H. V. van Osch, S. Naini, Andrea G. Brear, Ian Mcleod, Dirk M. Hentschel, J. Yates, S. van den Heuvel, J. Shah   +10 more
semanticscholar   +7 more sources