Results 51 to 60 of about 282,951 (269)

Ubiquitination site preferences in anaphase promoting complex/cyclosome (APC/C) substrates [PDF]

Open Biology, 2013
Ordered progression of mitosis requires precise control in abundance of mitotic regulators. The anaphase promoting complex/cyclosome (APC/C) ubiquitin ligase plays a key role by directing ubiquitin-mediated destruction of targets in a temporally and ...
Mingwei Min, Ugo Mayor, Catherine Lindon   +2 more
doaj   +1 more source

Regulation of OLC1 protein expression by the anaphase-promoting complex. [PDF]

Oncol Lett, 2019
Overexpressed in lung cancer 1 (OLC1) is a potential oncogene overexpressed in human lung cancer and in other types of malignant tumor. The elevated expression of OLC1 contributes to tumor genesis and progression. However, the mechanisms regulating the expression of OLC1 remain unclear. In the present study, using lung and esophageal cancer cell lines,
Zhang X, Chen W, Yin N, Dong L, Fu M, Zhan Q, Tong T.   +6 more
europepmc   +4 more sources

Phosphorylation of Sli15 by Ipl1 is important for proper CPC localization and chromosome stability in Saccharomyces cerevisiae [PDF]

, 2014
The chromosomal passenger complex (CPC) is a key regulator of eukaryotic cell division, consisting of the protein kinase Aurora B/Ipl1 in association with its activator (INCENP/Sli15) and two additional proteins (Survivin/Bir1 and Borealin/Nbl1). Here we
Corbishley, Stephen, Makrantoni, Vasso, Morrice, Nicholas A., Rachidi, Najma, Robinson, David A., Stark, Michael J. R.   +5 more
core   +4 more sources

Arabidopsis ULTRAVIOLET-B-INSENSITIVE4 maintains cell division activity by temporal inhibition of the anaphase-promoting complex/cyclosome [PDF]

, 2011
The anaphase-promoting complex/cyclosome (APC/C) is a multisubunit ubiquitin ligase that regulates progression through the cell cycle by marking key cell division proteins for destruction.
Berckmans, Barbara, Boudolf, Véronique, De Jaeger, Geert, De Veylder, Lieven, De Wit, Kevin, Heyman, Jefri, Koncz, Csaba, Lessa Alvim Kamei, Claire, Van Den Daele, Hilde, Verkest, Aurine   +9 more
core   +2 more sources

Novel functions for the anaphase-promoting complex in neurobiology [PDF]

Seminars in Cell & Developmental Biology, 2011
In recent years, diverse and unexpected neurobiological functions have been uncovered for the major cell cycle-regulated ubiquitin ligase, the anaphase-promoting complex (APC). Functions of the APC in the nervous system range from orchestrating neuronal morphogenesis and synapse development to the regulation of neuronal differentiation, survival, and ...
Azad Bonni, Sidharth V. Puram
openaire   +3 more sources

BubR1 is frequently repressed in acute myeloid leukemia and its re-expression sensitizes cells to antimitotic therapy

Haematologica, 2013
Spindle poison-based therapy is of only limited benefit in acute myeloid leukemia while lymphoblastic leukemia/lymphoma responds well. In this study, we demonstrated that the spindle assembly checkpoint protein BubR1 was down-regulated in the vast ...
Dominik Schnerch, Andrea Schmidts, Marie Follo, Josefina Udi, Julia Felthaus, Dietmar Pfeifer, Monika Engelhardt, Ralph Wäsch   +7 more
doaj   +1 more source

A minimal anaphase promoting complex/cyclosome (APC/C) in Trypanosoma brucei. [PDF]

PLoS ONE, 2013
The anaphase-promoting complex/cyclosome (APC/C) is a multi-subunit E3 ubiquitin ligase that initiates chromosome segregation and mitotic exit by targeting critical cell-cycle regulators for proteolytic destruction.
Mohamed Bessat, Giselle Knudsen, Alma L Burlingame, Ching C Wang   +3 more
doaj   +1 more source

Novel regulation of mitotic exit by the Cdc42 effectors Gic1 and Gic2 [PDF]

, 2004
Copyright @ The Rockefeller University PressThe guanine nucleotide exchange factor Cdc24, the GTPase Cdc42, and the Cdc42 effectors Cla4 and Ste20, two p21-activated kinases, form a signal transduction cascade that promotes mitotic exit in yeast.
Höfken, T, Schiebel, E
core   +2 more sources

How to halve ploidy : lessons from budding yeast meiosis [PDF]

, 2012
Maintenance of ploidy in sexually reproducing organisms requires a specialized form of cell division called meiosis that generates genetically diverse haploid gametes from diploid germ cells.
Arumugam, Prakash, Kerr, Gary W., Sarkar, Sourav   +2 more
core   +1 more source

Structural Insight into Anaphase Promoting Complex 3 Structure and Docking with a Natural Inhibitory Compound

Advanced Biomedical Research, 2017
Background: Anaphase promoting complex (APC) is the biggest Cullin-RING E3 ligase and is very important in cell cycle control; many anti-cancer agents target this.
Hamzeh Rahimi, Mohammad Ali Shokrgozar, Armin Madadkar-Sobhani, Reza Mahdian, Alireza Foroumadi, Morteza Karimipoor   +5 more
doaj   +1 more source