Results 51 to 60 of about 54,411 (234)
Developmental regulation of an organelle tether coordinates mitochondrial remodeling in meiosis. [PDF]
, 2018 Cellular differentiation involves remodeling cellular architecture to transform one cell type to another. By investigating mitochondrial dynamics during meiotic differentiation in budding yeast, we sought to understand how organelle morphogenesis is ...
Berchowitz, Luke +5 more
core +2 more sources
Meiotic nuclear divisions in budding yeast require PP2ACdc55-mediated antagonism of Net1 phosphorylation by Cdk [PDF]
, 2011 During meiosis, one round of deoxyribonucleic acid replication is followed by two rounds of nuclear division. In Saccharomyces cerevisiae, activation of the Cdc14 early anaphase release (FEAR) network is required for exit from meiosis I but does not lead
Arumugam, Prakash +5 more
core +3 more sources
Cell Reports, 2017 The anaphase-promoting complex/cyclosome (APC/C) is an E3 ubiquitin ligase that targets substrates for degradation to promote mitotic progression. Here, we show that the DNA damage response protein 53BP1 contains conserved KEN boxes that are required for
Thomas J. Kucharski +4 more
doaj +1 more source
The dynamics of replication licensing in live Caenorhabditis elegans embryos [PDF]
, 2012 Accurate DNA replication requires proper regulation of replication licensing, which entails loading MCM-2-7 onto replication origins. In this paper, we provide the first comprehensive view of replication licensing in vivo, using video microscopy of ...
Anton Gartner +56 more
core +4 more sources
Anaphase-Promoting Complex in Caenorhabditis elegans [PDF]
Molecular and Cellular Biology, 2004 Progression through critical events in cell division relies to a large extent on the destruction of key effectors of the cell cycle. An example can be seen in the regulation of the major cell cycle effector, the cyclin-dependent kinases (CDKs). CDKs depend upon the binding of their activators, the cyclins, to drive specific events at particular stages ...
openaire +2 more sources
M2I-1 disrupts the in vivo interaction between CDC20 and MAD2 and increases the sensitivities of cancer cell lines to anti-mitotic drugs via MCL-1s [PDF]
, 2019 Background Drugs such as taxanes, epothilones, and vinca alkaloids are widely used in the treatment of breast, ovarian, and lung cancers but come with major side effects such as neuropathy and loss of neutrophils and as single agents have a lack of ...
Dang, Nanmao +7 more
core +1 more source
Molecular architecture and mechanism of the anaphase-promoting complex [PDF]
Nature, 2014 The ubiquitination of cell cycle regulatory proteins by the anaphase-promoting complex/cyclosome (APC/C) controls sister chromatid segregation, cytokinesis and the establishment of the G1 phase of the cell cycle. The APC/C is an unusually large multimeric cullin-RING ligase.
Lei-Fu, Chang +4 more
openaire +2 more sources
The Drosophila MCPH1-B isoform is a substrate of the APCCdh1 E3 ubiquitin ligase complex
Biology Open, 2014 The Anaphase-Promoting Complex (APC) is a multi-subunit E3 ubiquitin ligase that coordinates progression through the cell cycle by temporally and spatially promoting the degradation of key proteins. Many of these targeted proteins have been shown to play
Sarah G. Hainline +4 more
doaj +1 more source
Cell Reports, 2021 Summary: The anaphase-promoting complex/cyclosome (APC/C) is an E3 ubiquitin ligase that controls cell cycle transitions. Its regulation by the spindle assembly checkpoint (SAC) is coordinated with the attachment of sister chromatids to the mitotic ...
Stanislau Yatskevich +10 more
doaj +1 more source
Baculovirus expression: tackling the complexity challenge [PDF]
, 2013 This article is made available for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source.
Barford, David +3 more
core +2 more sources