Results 61 to 70 of about 53,781 (249)

Smc5/6 coordinates formation and resolution of joint molecules with chromosome morphology to ensure meiotic divisions [PDF]

, 2013
During meiosis, Structural Maintenance of Chromosome (SMC) complexes underpin two fundamental features of meiosis: homologous recombination and chromosome segregation.
A Chavez, A De Muyt, A Hochwagen, A Hochwagen, A Irmisch, A McAleenan, A Schwacha, A Sourirajan, A Svetlanov, AC Chan, AJ Wood, AL Marston, Alex D. Herbert, Alice Copsey, Andreas Hochwagen, Andrew Chi-ho Chan, B Rockmill, BH Lee, C Buhler, C Tapia-Alveal, DM Sheedy, E Ampatzidou, EA Andrews, EA Outwin, ER Hoffmann, Eva Hoffmann, F Osman, FZ Watts, G De Piccoli, G Vader, GA Cromie, GR Smith, GV Borner, H Murakami, Hannah G. Blitzblau, HB Lindroos, HG Blitzblau, HG Blitzblau, HG Yu, HG Yu, I Lilienthal, J Gregan, J Matos, J Matos, J Palecek, J Pan, J Torres-Rosell, J Zalevsky, JA Carballo, JA Downs, JK Holloway, JM Murray, JR Mullen, JR Mullen, JS Bickel, K Nishimura, K Zakharyevich, K Zakharyevich, KA Henderson, KP Kim, KP Kohl, KT Nishant, L Jessop, L Jessop, L Newnham, L Wu, L Xu, LE Berchowitz, LE Hang, LJ Gaskell, Louise Newnham, M Bermudez-Lopez, M Xaver, MA Roy, Michael Lichten, MJ Neale, MN Boddy, MS McMahill, N Hunter, N Hunter, N Wu, Neil Hunter, NK Kolas, O Yildiz, P Jordan, Philip W. Jordan, PR Potts, PR Potts, Prakash Arumugam, RK Clyne, S Agarwal, S Chu, S Farmer, S Gray, S Panizza, S Pebernard, S Wehrkamp-Richter, SB Buonomo, SD Oh, SD Oh, Shangming Tang, SL Andersen, Sonya Newcombe, Stephen Gray, T de los Santos, T Snowden, T Wechsler, TM Carlile, TS Kitajima, V Kaliraman, WM Fricke, X Zhao, Y Blat, YH Chen, YH Chen, Zhaobo Li   +115 more
core   +3 more sources

Molecular mechanisms of APC/C release from spindle assembly checkpoint inhibition by APC/C SUMOylation

Cell Reports, 2021
Summary: The anaphase-promoting complex/cyclosome (APC/C) is an E3 ubiquitin ligase that controls cell cycle transitions. Its regulation by the spindle assembly checkpoint (SAC) is coordinated with the attachment of sister chromatids to the mitotic ...
Stanislau Yatskevich, Jessie S. Kroonen, Claudio Alfieri, Thomas Tischer, Anna C. Howes, Linda Clijsters, Jing Yang, Ziguo Zhang, Kaige Yan, Alfred C.O. Vertegaal, David Barford   +10 more
doaj   +1 more source

Baculovirus expression: tackling the complexity challenge [PDF]

, 2013
This article is made available for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source.
Barford, David, Berger, Imre, Schultz, Patrick, Takagi, Yuichiro   +3 more
core   +2 more sources

The Drosophila MCPH1-B isoform is a substrate of the APCCdh1 E3 ubiquitin ligase complex

Biology Open, 2014
The Anaphase-Promoting Complex (APC) is a multi-subunit E3 ubiquitin ligase that coordinates progression through the cell cycle by temporally and spatially promoting the degradation of key proteins. Many of these targeted proteins have been shown to play
Sarah G. Hainline, Jamie L. Rickmyre, Leif R. Neitzel, Laura A. Lee, Ethan Lee   +4 more
doaj   +1 more source

M2I-1 disrupts the in vivo interaction between CDC20 and MAD2 and increases the sensitivities of cancer cell lines to anti-mitotic drugs via MCL-1s [PDF]

, 2019
Background Drugs such as taxanes, epothilones, and vinca alkaloids are widely used in the treatment of breast, ovarian, and lung cancers but come with major side effects such as neuropathy and loss of neutrophils and as single agents have a lack of ...
Dang, Nanmao, Gao, Fei, Huang, Dong, Huang, Jun-Yong, Jowsey, Paul, Li, Jianquan, Lightowlers, Robert N., Martinez-Lopez, Nuria   +7 more
core   +1 more source

Modeling Dual Pathways for the Metazoan Spindle Assembly Checkpoint [PDF]

, 2006
Using computational modelling, we investigate mechanisms of signal transduction focusing on the spindle assembly checkpoint where a single unattached kinetochore is able to signal to prevent cell cycle progression.
Acquaviva, Castro, Clute, De Antoni, DeAntoni, Heinrich, Howell, Kraft, Lang, Luo, M. Howard, Mapelli, McEwen, Musacchio, Nasmyth, Nickell, Northrup, Pan, R. P. Sear, Rieder, Rieder, Rieder, Shah, Sironi, Sudakin, Tang, Tang, Vink, Wojcieszyn, Wollman   +29 more
core   +3 more sources

Securin Is Not Required for Chromosomal Stability in Human Cells [PDF]

, 2005
Abnormalities of chromosome number are frequently observed in cancers. The mechanisms regulating chromosome segregation in human cells are therefore of great interest.
Azofeifa, Bunz, Cahill, Ciosk, Cohen-Fix, Funabiki, Giménez-Abián, Gorr, Gruber, Haering, Hauf, Hauf, Huang, Jallepalli, Jürgen Cox, Katrin Pfleghaar, Losada, McGuinness, Mei, Michael R Speicher, Michor, Nasmyth, Olaf Stemmann, R. Scott Hawley, Ramos-Morales, Saez, Simone Heubes, Speicher, Stemmann, Stemmann, Uhlmann, Waizenegger, Zou   +32 more
core   +4 more sources

Phase‐Separation of YAP Mediates AJUBA Super Enhancer Activation to Promote Aberrant Mitosis in Breast Cancer

Advanced Science, EarlyView.
YAP undergoes phase separation to activate the AJUBA super‐enhancer, driving aberrant mitosis through spindle checkpoint dysregulation in breast cancer. This study uncovers a mechanistic link between YAP condensates, super‐enhancer activation, and aneuploidy formation.
Rui Zhang, Qingwen Huang, Zhuo Chen, Weijian Meng, Hongliang Dong, Zhihong Qi, Liang Liu, Jie Shen, Daxing Xie   +8 more
wiley   +1 more source

CCDC41 Drives Oocyte Meiotic Progression by Promoting Rab11a/Rab7‐Positive Vesicle Fusion with Target Membranes

Advanced Science, EarlyView.
CCDC41 is essential for meiotic maturation in mouse oocytes through regulating Rab7‐positive endosomes fusion with lysosomes and Rab11a‐positive vesicle fusion with the plasma membrane. Abstract Coiled‐coil domain‐containing protein 41 (CCDC41), a core component of centriolar distal appendages involved in centriole assembly and ciliary vesicle docking,
Ying Tian, Jiatong Li, Jingyi Kang, Xiangning Xu, Bicheng Wang, Shuo Lou, Jingyu Li, Yuying Yang, Yanbing Zhang, Yangzi Zheng, Jing Weng, Yuanjing Liang, Wei Ma   +12 more
wiley   +1 more source

Anaphase-Promoting Complex in Caenorhabditis elegans [PDF]

Molecular and Cellular Biology, 2004
Progression through critical events in cell division relies to a large extent on the destruction of key effectors of the cell cycle. An example can be seen in the regulation of the major cell cycle effector, the cyclin-dependent kinases (CDKs). CDKs depend upon the binding of their activators, the cyclins, to drive specific events at particular stages ...
openaire   +2 more sources