The FEAR protein Slk19 restricts Cdc14 phosphatase to the nucleus until the end of anaphase, regulating its participation in mitotic exit in Saccharomyces cerevisiae. [PDF]
PLoS ONE, 2013 In Saccharomyces cerevisiae mitosis, the protein Slk19 plays an important role in the initial release of Cdc14 phosphatase from the nucleolus to the nucleus in early anaphase, an event that is critical for proper anaphase progression. A role for Slk19 in
Ann Marie E Faust +4 more
doaj +1 more source
Journal of Cell Biology, 2014 Active recruitment of Aurora B and its counteracting phosphatase PP2A–B56 to the anaphase spindle is promoted by the kinesins MKlp2 and KIF4A, respectively.
R. Bastos, M. J. Cundell, F. Barr
semanticscholar +1 more source
Mitotic Cdc6 Stabilizes Anaphase-Promoting Complex Substrates by a Partially Cdc28-Independent Mechanism, and This Stabilization Is Suppressed by Deletion of Cdc55 [PDF]
, 2006 Ectopic expression of Cdc6p results in mitotic delay, and this has been attributed to Cdc6p-mediated inhibition of Cdc28 protein kinase and failure to activate the anaphase-promoting complex (APC).
Boronat, Susanna, Campbell, Judith L.
core +2 more sources
The Anaphase-Promoting Complex/Cyclosome Is Required for Anaphase Progression in Multinucleated Ashbya gossypii Cells [PDF]
Eukaryotic Cell, 2007 ABSTRACT Regulated protein degradation is essential for eukaryotic cell cycle progression. The anaphase-promoting complex/cyclosome (APC/C) is responsible for the protein destruction required for the initiation of anaphase and the exit from mitosis, including the degradation of securin and B-type cyclins.
Gladfelter, A. S. +5 more
openaire +3 more sources
Chiasmata promote monopolar attachment of sister chromatids and their co-segregation toward the proper pole during meiosis I. [PDF]
PLoS Genetics, 2011 The chiasma is a structure that forms between a pair of homologous chromosomes by crossover recombination and physically links the homologous chromosomes during meiosis. Chiasmata are essential for the attachment of the homologous chromosomes to opposite
Yukinobu Hirose +8 more
doaj +1 more source
Molecular Biology of the Cell, 2014 The mitotic apparatus protein NuMA has an intrinsic membrane-targeting mechanism that is regulated by CDK1-mediated phosphorylation, underlies anaphase-specific cortical accumulation of dynein, and contributes to chromosome separation.
Zhen Zheng +3 more
semanticscholar +1 more source
The Anaphase-Promoting Complex (APC) ubiquitin ligase affects chemosensory behavior in \u3cem\u3eC. elegans\u3c/em\u3e [PDF]
, 2016 The regulation of fundamental aspects of neurobiological function has been linked to the ubiquitin signaling system (USS), which regulates the degradation and activity of proteins and is catalyzed by E1, E2, and E3 enzymes. The Anaphase-Promoting Complex
Jennings, Alexandra K. +2 more
core +3 more sources
Cell Division: SACing the Anaphase Problem [PDF]
Current Biology, 2014 Errors in chromosome segregation are safeguarded by the spindle assembly checkpoint. Yet the very defects that trigger this checkpoint are inescapable consequences of sister chromatid segregation in anaphase. Three new studies provide clues to how cells cope with this problem.
openaire +3 more sources
On the origins of ultra-fine anaphase bridges [PDF]
Cell Cycle, 2009 Comment on: Chan KL, Palmai-Pallag T, Ying S, Hickson ID. Replication stress induces sister-chromatid bridging at fragile site loci in mitosis. Nat Cell Biol 2009; 11:753-60.
Kok-Lung Chan, Ian D. Hickson
openaire +2 more sources
Automated three-dimensional single cell phenotyping of spindle dynamics, cell shape, and volume [PDF]
arXiv, 2015 We present feature finding and tracking algorithms in 3D in living cells, and demonstrate their utility to measure metrics important in cell biological processes. We developed a computational imaging hybrid approach that combines automated three-dimensional tracking of point-like features with surface determination from which cell (or nuclear) volume ...
arxiv