Results 81 to 90 of about 134,346 (229)

Trace Levels of Triclosan May Affect Root Growth and Morphology in Cultivated Plants

Environmental Toxicology, EarlyView.
ABSTRACT Triclosan (TCS) is a micropollutant frequently detected in biosolids applied to agricultural soils. In soil solution—where it is potentially bioavailable to roots—it occurs at residual concentrations (ng L−1). Nevertheless, the ecotoxicological implications of TCS exposure in agricultural crops at these concentrations are still not fully ...
Lizandra de Souza Ratuchinski, Edson Araujo de Almeida, Matheus Cristiano Hermann Massariol, Diego Espirito Santo, Carmem Lúcia Henrich, Bianca da Cruz, Danielle Cristina da Silva de Oliveira, Gideã Taques Tractz, Regiane da Silva Gonzalez, Osvaldo Valarini Junior, Ana Paula Peron   +10 more
wiley   +1 more source

Cohesin is dispensable for centromere cohesion in human cells.

PLoS ONE, 2007
BackgroundProper regulation of the cohesion at the centromeres of human chromosomes is essential for accurate genome transmission. Exactly how cohesion is maintained and is then dissolved in anaphase is not understood.Principal findingsWe have ...
Laura A Díaz-Martínez, Juan F Giménez-Abián, Duncan J Clarke   +2 more
doaj   +1 more source

Chromosome Bridges Maintain Kinetochore-Microtubule Attachment throughout Mitosis and Rarely Break during Anaphase. [PDF]

PLoS ONE, 2016
Accurate chromosome segregation during cell division is essential to maintain genome stability, and chromosome segregation errors are causally linked to genetic disorders and cancer.
Judit Pampalona, Emanuele Roscioli, William T Silkworth, Brent Bowden, Anna Genescà, Laura Tusell, Daniela Cimini   +6 more
doaj   +1 more source

Chromosomal and immune dysregulation underlying granular mitosis in glioblastoma

Brain Pathology, EarlyView.
Granular mitosis (GM) morphology is linked to PI3K/PTEN pathway alterations, chromosomal disorganization, and impaired innate immunity. Cells exhibiting GM morphology are associated with localized immune responses within their immediate spatial microenvironment.
Rachel Barboza, Xuan Wang, August Lin, Eric Liu, Pramath Kakodkar, Yayuan Zhao, Quinn Le, Christina A. Castellani, Qi Zhang   +8 more
wiley   +1 more source

Structures of the UBR4 complex reveal a giant arena to capture diverse substrates for ubiquitin chain elongation

The FEBS Journal, EarlyView.
This review summarizes recent structures of the UBR4 complex, a giant E4 ubiquitin ligase which recognizes proteins with pre‐existing ubiquitin modifications and marks them for degradation. The UBR4 complex uses a large arena lined with substrate interaction modules to select features on ubiquitinated substrates, such as the presence of N‐degrons or ...
Daniel B. Grabarczyk, Tim Clausen
wiley   +1 more source

Investigation of FEAR and MEN pathway homologs in multinucleate cells [PDF]

, 2011
The cell cycle is a sequence of events enabling a cell to replicate and proliferate. Common landmark events in most eukaryotic cell cycles are duplication of the DNA, mitosis, and cell separation.
Finlayson, Mark
core   +1 more source

The RepID–CRL4 ubiquitin ligase complex regulates metaphase to anaphase transition via BUB3 degradation

Nature Communications, 2020
The spindle assembly checkpoint (SAC) safeguards chromosome segregation by regulating the anaphase promoting complex/cyclosome (APC/C), allowing chromosomes to correctly attach to mitotic spindles. Here the authors reveal a role for Cullin–RING ubiquitin
Sang-Min Jang, Jenny F. Nathans, Haiqing Fu, Christophe E. Redon, Lisa M. Jenkins, Bhushan L. Thakur, Lőrinc S. Pongor, Adrian M. Baris, Jacob M. Gross, Maura J. OʹNeill, Fred E. Indig, Steven D. Cappell, Mirit I. Aladjem   +12 more
doaj   +1 more source

A guide to transcriptional cyclin‐dependent kinases in cancer

The FEBS Journal, EarlyView.
Transcriptional cyclin‐dependent‐kinases (tCDKs) facilitate gene expression by promoting RNA polymerase II (RNAPII) progression through discrete phases of the transcription cycle. Aberrant tCDK activity is detectable in different human cancers, thereby contributing to de‐regulated gene expression programs that drive oncogenic phenotypes.
Jennifer R. Devlin, Salla Kyheröinen, Ricky W. Johnstone   +2 more
wiley   +1 more source

Real time observation of anaphase in vitro. [PDF]

, 1996
We used digital fluorescence microscopy to make real-time observations of anaphase chromosome movement and changes in microtubule organization in spindles assembled in Xenopus egg extracts.
E. D. Salmon, Salmon, E. D., Desai, A. B., A. W. Murray, Murray, A. W., A. B. Desai   +5 more
core   +1 more source

UK recommendations for Ki‐67 immunohistochemical staining and interpretation in breast cancer

Histopathology, EarlyView.
Where possible, a validated digital imaging system should be utilized. If this is not available, then intermediate scores (5%–30%) should be thoroughly assessed using the Ki‐67 International Working Group guidance. Difficult cases should be double scored.
Abeer M Shaaban, Andrew Dodson, Emad Rakha, Ian Ellis, Daniel Rea, Cecily Quinn, Elena Provenzano, Sarah Pinder, on behalf of the UK National Coordinating Committee for Breast Pathology (NCCBP), Association of Breast Pathology (ABP) and the UK National External Quality Assessment Scheme for Immunohistochemistry and In Situ Hybridisation (UK NEQAS ICC & ISH)   +9 more
wiley   +1 more source