Results 61 to 70 of about 137,810 (238)
Specificity of the Anaphase Promoting Complex: a single-molecule study
Science, 2015 Single-molecule assay of ubiquitylation Many biological processes in cells are regulated by ubiquitin peptides that are attached to proteins. Measurement of single fluorescent molecules in cell extracts can be used to trace the kinetics of such reactions.
Ying Lu, Weiping Wang, M. Kirschner
semanticscholar +1 more source
Advanced Science, EarlyView.ABSTRACT The muscle capsule of Trichinella is a critical structure that impedes immune attacks and drug penetration, yet the molecular mechanisms underlying its formation remain poorly understood. Using a high‐quality super‐pangenome comprising 12 Trichinella species, we compared extensive genomic variations between encapsulating and non‐encapsulating ...
Qingbo Lv +8 more
wiley +1 more source
Multipolar spindle pole coalescence is a major source of kinetochore mis-attachment and chromosome mis-segregation in cancer cells. [PDF]
PLoS ONE, 2009 Many cancer cells display a CIN (Chromosome Instability) phenotype, by which they exhibit high rates of chromosome loss or gain at each cell cycle. Over the years, a number of different mechanisms, including mitotic spindle multipolarity, cytokinesis ...
William T Silkworth +3 more
doaj +1 more source
Covalent Reprogramming of Kinase Binders to Modulate Protein Abundance
Advanced Science, EarlyView.Electrophilic remodeling of a broad‐spectrum kinase binder reveals how subtle chemical changes reprogram protein fate. An acrylamide analog of a multi‐kinase binder selectively stabilizes Aurora kinase A (AURKA) by suppressing its ubiquitination, while a short‐linker variant converts this stabilizer into a degrader.
Chen Mozes +4 more
wiley +1 more source
Meiotic behavior of small chromosomes in maize
Frontiers in Plant Science, 2013 The typical behavior of chromosomes in meiosis is that homologous pairs synapse, recombine and then separate at anaphase I. At anaphase II, sister chromatids separate.
James A. Birchler, Fangpu eHan
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eLife, 2020 During mitosis, the Spindle Assembly Checkpoint (SAC) maintains genome stability while also ensuring timely anaphase onset. To maintain genome stability, the SAC must be strong to delay anaphase even if just one chromosome is unattached, but for timely ...
Babhrubahan Roy +3 more
doaj +1 more source
Condensin II resolves chromosomal associations to enable anaphase I segregation in Drosophila male meiosis. [PDF]
PLoS Genetics, 2008 Several meiotic processes ensure faithful chromosome segregation to create haploid gametes. Errors to any one of these processes can lead to zygotic aneuploidy with the potential for developmental abnormalities.
Tom A Hartl +3 more
doaj +1 more source
Cyclin B3 Is a Mitotic Cyclin that Promotes the Metaphase-Anaphase Transition
Current Biology, 2015 Summary The timing mechanism for mitotic progression is still poorly understood. The spindle assembly checkpoint (SAC), whose reversal upon chromosome alignment is thought to time anaphase [1–3], is functional during the rapid mitotic cycles of the ...
Kai Yuan, P. O’Farrell
semanticscholar +1 more source
Advanced Science, EarlyView.ZDHHC17 palmitoylates CDK4, which together with TRAF6‐mediated ubiquitination, drives cell cycle progression and immune surveillance, revealing a rational combination of CDK4 inhibitors with immune checkpoint blockers for ZDHHC17‐driven cancers. ABSTRACT Uncontrolled cell cycle progression is a hallmark of cancer, tightly regulated by both intrinsic ...
Zekang Wang +7 more
wiley +1 more source
A theoretical model of anaphase
Mathematical BiosciencesThis paper develops a theory for anaphase in cells. After a brief description of microtubules, the mitotic spindle and the centrosome, a mathematical model for anaphase is introduced and developed in the context of the cell cytoplasm and liquid crystalline structures.
Sleeman, Brian D., Stewart, Iain W.
openaire +4 more sources