Results 41 to 50 of about 134,346 (229)
CDK-dependent nuclear localization of B-Cyclin Clb1 promotes FEAR activation during meiosis I in budding yeast [PDF]
, 2013 Cyclin-dependent kinases (CDK) are master regulators of the cell cycle in eukaryotes. CDK activity is regulated by the presence, post-translational modification and spatial localization of its regulatory subunit cyclin.
Sarkar, S. (Sourav) +19 more
core +2 more sources
The Plant Anaphase-Promoting Complex/Cyclosome
Annual Review of Cell and Developmental Biology, 2022 The anaphase-promoting complex/cyclosome (APC/C) represents a large multisubunit E3-ubiquitin ligase complex that controls the unidirectional progression through the cell cycle by the ubiquitination of specific target proteins, marking them for proteasomal destruction.
Willems, Alex, De Veylder, Lieven
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Spatiotemporal regulation of MELK during mitosis
Frontiers in Cell and Developmental BiologyMaternal Embryonic Leucine Zipper Kinase (MELK) has been studied intensively in recent years due to its overexpression in multiple cancers. However, the cell biology of MELK remains less characterized despite its well-documented association with mitosis.
Sreemita Majumdar, Song-Tao Liu
doaj +1 more source
Nur1 dephosphorylation confers positive feedback to mitotic exit phosphatase activation in budding yeast. [PDF]
PLoS Genetics, 2015 Substrate dephosphorylation by the cyclin-dependent kinase (Cdk)-opposing phosphatase, Cdc14, is vital for many events during budding yeast mitotic exit.
Molly Godfrey +2 more
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Functional characterization of PICH, a DNA-dependent ATPase required for faithful chromosome segregation during mitosis [PDF]
, 2010 PICH (Plk1-interacting checkpoint helicase), a DNA-dependent ATPase, was identified as a binding partner and substrate of Plk1. During mitosis, PICH localizes to the centromere/KTs of condensed mitotic chromosomes and to ultra-fine DNA bridges (UFBs ...
Kaulich, Manuel
core +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
Degradation of the kinesin Kip1p at anaphase onset is mediated by the anaphase-promoting complex and Cdc20p [PDF]
Proceedings of the National Academy of Sciences, 2001 Kip1p of Saccharomyces cerevisiae is a bipolar kinesin in the conserved bimC kinesin subfamily that mediates mitotic spindle–pole separation. Here, we show that Kip1p is regulated immediately after anaphase initiation by its rapid degradation. Degradation required the ubiquitin protein ligase
D M, Gordon, D M, Roof
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eLifeThe cohesin complex maintains sister chromatid cohesion from S phase to anaphase onset. Cohesin also plays roles in chromosome structure and DNA repair.
Jessel Ayra Plasencia +5 more
doaj +1 more source
PLoS ONE, 2012 Centromeres are specialized chromosome domains that control chromosome segregation during mitosis, but little is known about the mechanisms underlying the maintenance of their integrity.
Sébastien Rouzeau +8 more
doaj +1 more source