Results 31 to 40 of about 134,346 (229)
A Regulatory Switch Alters Chromosome Motions at the Metaphase-to-Anaphase Transition
Cell Reports, 2016 To achieve chromosome segregation during mitosis, sister chromatids must undergo a dramatic change in their behavior to switch from balanced oscillations at the metaphase plate to directed poleward motion during anaphase.
Kuan-Chung Su +5 more
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Some assembly required: Redefining the mitotic checkpoint
Molecular & Cellular Oncology, 2017 The spindle assembly checkpoint (also known as the spindle or mitotic checkpoint) is a surveillance system that ensures fidelity of chromosome segregation.
John C. Meadows, Jonathan B. A. Millar
doaj +1 more source
Cell Reports, 2015 Condensin is a conserved chromosomal complex necessary to promote mitotic chromosome condensation and sister chromatid resolution during anaphase. Here, we report that yeast condensin binds to replicated centromere regions.
Joanne Leonard +6 more
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The preprophase band is dispensable for robust cell division orientation in wood-forming cambium stem cells. [PDF]
New PhytolCharacterization of periclinal and anticlinal cell divisions in dividing cambium stem cells (CSCs). (a) Scheme indicating periclinal and anticlinal cell divisions in CSCs in the Arabidopsis hypocotyl. The orange dashed ring in the middle panel represents the cambium area. The orange cuboids represent individual CSCs.
Liu X +4 more
europepmc +2 more sources
Bub1-mediated adaptation of the spindle checkpoint. [PDF]
PLoS Genetics, 2011 During cell division, the spindle checkpoint ensures accurate chromosome segregation by monitoring the kinetochore-microtubule interaction and delaying the onset of anaphase until each pair of sister chromosomes is properly attached to microtubules.
Greicy H Goto +4 more
doaj +1 more source
Phosphorylation of Sli15 by Ipl1 is important for proper CPC localization and chromosome stability in Saccharomyces cerevisiae [PDF]
, 2014 The chromosomal passenger complex (CPC) is a key regulator of eukaryotic cell division, consisting of the protein kinase Aurora B/Ipl1 in association with its activator (INCENP/Sli15) and two additional proteins (Survivin/Bir1 and Borealin/Nbl1). Here we
David A Robinson +17 more
core +1 more source
Early onset of APC/C activity renders SAC inefficient in mouse embryos
Frontiers in Cell and Developmental BiologyControl mechanisms of spindle assembly and chromosome segregation are vital for preventing aneuploidy during cell division. The mammalian germ cells and embryos are prone to chromosome segregation errors, and the resulting aneuploidy is a major cause of ...
Adela Horakova +9 more
doaj +1 more source
CENP-F-dependent DRP1 function regulates APC/C activity during oocyte meiosis I
Nature Communications, 2022 Spindle assembly checkpoint controls anaphase onset and guarantees appropriate chromosome segregation. Here, the authors report that dynamin-related protein 1 is recruited to kinetochores by CENP-F to regulate metaphase-to-anaphase transition by ...
Cheng-Jie Zhou +8 more
doaj +1 more source
Keeping Order in Anaphase [PDF]
Developmental Cell, 2015 The critical components of chromosome segregation machinery are well established, but how they orchestrate the relative order of events during mitosis remains unclear. Kamenz et al. (2015) now report in Molecular Cell quantitative data suggesting competing networks and adaptive thresholds in the control of mitotic exit by the anaphase-promoting complex.
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Anaphase Promoting Complex or Cyclosome? [PDF]
Cell Cycle, 2005 The anaphase promoting complex/cyclosome (APC/C) was initially described as a multi-subunit protein complex that ubiquitinates anaphase inhibitors thus targeting them for destruction by proteasomes to initiate loss of sister chromatid cohesion. However, recent studies have identified important new functions of the APC/C.
Duncan J, Clarke +2 more
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