Results 21 to 30 of about 137,810 (238)
The perpetual movements of anaphase [PDF]
Cellular and Molecular Life Sciences, 2010 One of the most extraordinary events in the lifetime of a cell is the coordinated separation of sister chromatids during cell division. This is truly the essence of the entire mitotic process and the reason for the most profound morphological changes in cytoskeleton and nuclear organization that a cell may ever experience.
Maiato, H, Lince-Faria, M
openaire +3 more sources
Rif1 Regulates the Fate of DNA Entanglements during Mitosis
Cell Reports, 2016 Clearance of entangled DNA from the anaphase mid-region must accurately proceed in order for chromosomes to segregate with high fidelity. Loss of Taz1 (fission yeast ortholog of human TRF1/TRF2) leads to stalled telomeric replication forks that trigger ...
Sophie Zaaijer +3 more
doaj +1 more source
Anaphase B Precedes Anaphase A in the Mouse Egg [PDF]
Current Biology, 2012 Segregation of chromosomes at the time of cell division is achieved by the microtubules and associated molecules of the spindle. Chromosomes attach to kinetochore microtubules (kMTs), which extend from the spindle pole region to kinetochores assembled upon centromeric DNA.
openaire +3 more sources
Journal of Cell Biology, 2019 Chromosome alignment at the equator of the mitotic spindle is a highly conserved step during cell division; however, its importance to genomic stability and cellular fitness is not understood.
Cindy L. Fonseca +10 more
semanticscholar +1 more source
The anaphase-promoting complex: proteolysis in mitosis and beyond. [PDF]
Molecular Cell, 2002 J. Peters
semanticscholar +2 more sources
Cell Reports, 2017 The onset of anaphase is triggered by activation of the anaphase-promoting complex/cyclosome (APC/C) following silencing of the spindle assembly checkpoint (SAC).
John C. Meadows +7 more
doaj +1 more source
APC/C-Cdh1-targeted substrates as potential therapies for Alzheimer’s disease
Frontiers in Pharmacology, 2022 Alzheimer’s disease (AD) is the most prevalent neurodegenerative disorder and the main cause of dementia in the elderly. The disease has a high impact on individuals and their families and represents a growing public health and socio-economic burden ...
Rebeca Lapresa +7 more
doaj +1 more source
Force-generating mechanisms of anaphase in human cells
Journal of Cell Science, 2019 What forces drive chromosome segregation remains one of the most challenging questions in cell division. Even though the duration of anaphase is short, it is of utmost importance for genome fidelity that no mistakes are made.
Kruno Vukušić, Renata Buđa, I. Tolic
semanticscholar +1 more source
Journal of Cell Biology, 2003 The Aurora/Ipl1 family of protein kinases plays multiple roles in mitosis and cytokinesis. Here, we describe ZM447439, a novel selective Aurora kinase inhibitor.
Claire Ditchfield +8 more
semanticscholar +1 more source
Visualizing the complex functions and mechanisms of the anaphase promoting complex/cyclosome (APC/C)
Open Biology, 2017 The anaphase promoting complex or cyclosome (APC/C) is a large multi-subunit E3 ubiquitin ligase that orchestrates cell cycle progression by mediating the degradation of important cell cycle regulators.
C. Alfieri, Suyang Zhang, D. Barford
semanticscholar +1 more source