Results 21 to 30 of about 134,346 (229)

Relocation of Aurora B from centromeres to the central spindle at the metaphase to anaphase transition requires MKlp2 [PDF]

, 2004
Mitotic kinases of the Polo and Aurora families are key regulators of chromosome segregation and cytokinesis. Here, we have investigated the role of MKlp1 and MKlp2, two vertebrate mitotic kinesins essential for cytokinesis, in the spatial regulation of ...
Erich A. Nigg, Francis A. Barr, Barr, FA, Neef, Rüdiger, Nigg, EA, Rüdiger Neef, Gruneberg, Ulrike, Honda, R, Ulrike Gruneberg, Nigg, Erich A., Neef, R, Reiko Honda, Honda, Reiko, Barr, Francis A.   +13 more
core   +1 more source

Ultrafine anaphase bridges, broken DNA and illegitimate recombination induced by a replication fork barrier [PDF]

, 2011
Most DNA double-strand breaks (DSBs) in S- and G2-phase cells are repaired accurately by Rad51-dependent sister chromatid recombination. However, a minority give rise to gross chromosome rearrangements (GCRs), which can result in disease/death.
Ledesma, Jennifer, Whitby, Matthew C., Castagnetti, S, Sofueva, Sevil, Alexander Lorenz, Steinacher, R, Fekret Osman, Lorenz, Alexander, Sofueva, S, Ledesma, J, Castagnetti, Stefania, Whitby, Matthew, Steinacher, Roland, Sevil Sofueva, Stefania Castagnetti, Osman, F, Lorenz, A, Matthew C. Whitby, Whitby, MC, Osman, Fekret, Roland Steinacher, Jennifer Ledesma   +21 more
core   +1 more source

Identification of a Sgo2-Dependent but Mad2-Independent Pathway Controlling Anaphase Onset in Fission Yeast

Cell Reports, 2017
The onset of anaphase is triggered by activation of the anaphase-promoting complex/cyclosome (APC/C) following silencing of the spindle assembly checkpoint (SAC).
John C. Meadows, Theresa C. Lancaster, Graham J. Buttrick, Alicja M. Sochaj, Liam J. Messin, Maria del Mar Mora-Santos, Kevin G. Hardwick, Jonathan B.A. Millar   +7 more
doaj   +1 more source

APC/C-Cdh1-targeted substrates as potential therapies for Alzheimer’s disease

Frontiers in Pharmacology, 2022
Alzheimer’s disease (AD) is the most prevalent neurodegenerative disorder and the main cause of dementia in the elderly. The disease has a high impact on individuals and their families and represents a growing public health and socio-economic burden ...
Rebeca Lapresa, Rebeca Lapresa, Jesus Agulla, Jesus Agulla, Juan P. Bolaños, Juan P. Bolaños, Angeles Almeida, Angeles Almeida   +7 more
doaj   +1 more source

Fission yeast bub1 is a mitotic centromere protein essential for the spindle checkpoint and the preservation of correct ploidy through mitosis [PDF]

, 1998
The spindle checkpoint ensures proper chromosome segregation by delaying anaphase until all chromosomes are correctly attached to the mitotic spindle.
Javerzat, Jean-Paul, Javerzat, J P, Bernard, P, Hardwick, K.G., Hardwick, Kevin, Bernard, Pascal, Pascal Bernard, Jean-Paul Javerzat, Kevin Hardwick   +8 more
core   +1 more source

Bub3p facilitates spindle checkpoint silencing in fission yeast [PDF]

, 2009
Although critical for spindle checkpoint signaling, the role kinetochores play in anaphase promoting complex (APC) inhibition remains unclear. Here we show that spindle checkpoint proteins are severely depleted from unattached kinetochores in fission ...
Hardwick, Kevin G., Millar, Jonathan B.A., van der Sar, Sjaak J. A., van der Sar, Sjaak J A, van Der Sar, Sjaak J.A., Millar, Jonathan B. A., Vanoosthuyse, Vincent, Millar, Jonathan B A, Meadows, John C, Vanoosthuyse, V., Hardwick, Kevin, Meadows, John, Meadows, John C., Hardwick, Kevin G   +13 more
core   +1 more source

Aurora B suppresses microtubule dynamics and limits central spindle size by locally activating KIF4A [PDF]

, 2013
Anaphase central spindle formation is controlled by the microtubule-stabilizing factor PRC1 and the kinesin KIF4A. We show that an MKlp2-dependent pool of Aurora B at the central spindle, rather than global Aurora B activity, regulates KIF4A accumulation
Erich A. Nigg, Francis A. Barr, Baron, Ryan D., Ricardo Nunes Bastos, Nunes Bastos, R, Ryan D. Baron, Nigg, EA, Gruneberg, Ulrike, Gandhi, Sapan R., Baron, RD, Barr, Francis, Gandhi, SR, Nunes Bastos, Ricardo, Ulrike Gruneberg, Nigg, Erich A., Sapan R. Gandhi, Barr, Francis A.   +16 more
core   +1 more source

Male meiotic spindle features that efficiently segregate paired and lagging chromosomes

eLife, 2020
Chromosome segregation during male meiosis is tailored to rapidly generate multitudes of sperm. Little is known about mechanisms that efficiently partition chromosomes to produce sperm.
Gunar Fabig, Robert Kiewisz, Norbert Lindow, James A Powers, Vanessa Cota, Luis J Quintanilla, Jan Brugués, Steffen Prohaska, Diana S Chu, Thomas Müller-Reichert   +9 more
doaj   +1 more source

Pathogenic mutations in the chromokinesin KIF22 disrupt anaphase chromosome segregation

eLife, 2022
The chromokinesin KIF22 generates forces that contribute to mitotic chromosome congression and alignment. Mutations in the α2 helix of the motor domain of KIF22 have been identified in patients with abnormal skeletal development, and we report the ...
Alex F Thompson, Patrick R Blackburn, Noah S Arons, Sarah N Stevens, Dusica Babovic-Vuksanovic, Jane B Lian, Eric W Klee, Jason Stumpff   +7 more
doaj   +1 more source

Anaphase in vitro. [PDF]

Proceedings of the National Academy of Sciences, 1996
Despite their varied appearances, all mitotic spindles have a similar architecture: they are organized as two half spindles, and the microtubules in each half spindle are of the same polarity, with many of the plus ends of the microtubules that grow out from the poles interacting with chromosomes or the microtubules of the other half spindle.
W Z, Cande, H J, Wein
openaire   +2 more sources