Results 11 to 20 of about 120,539 (178)
Biology, 2016 Anaphase B spindle elongation is characterized by the sliding apart of overlapping antiparallel interpolar (ip) microtubules (MTs) as the two opposite spindle poles separate, pulling along disjoined sister chromatids, thereby contributing to chromosome ...
Jonathan M. Scholey +2 more
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Cell Reports, 2017 The onset of anaphase is triggered by activation of the anaphase-promoting complex/cyclosome (APC/C) following silencing of the spindle assembly checkpoint (SAC).
John C. Meadows +7 more
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APC/C-Cdh1-targeted substrates as potential therapies for Alzheimer’s disease
Frontiers in Pharmacology, 2022 Alzheimer’s disease (AD) is the most prevalent neurodegenerative disorder and the main cause of dementia in the elderly. The disease has a high impact on individuals and their families and represents a growing public health and socio-economic burden ...
Rebeca Lapresa +7 more
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Proceedings of the National Academy of Sciences, 1996 Despite their varied appearances, all mitotic spindles have a similar architecture: they are organized as two half spindles, and the microtubules in each half spindle are of the same polarity, with many of the plus ends of the microtubules that grow out from the poles interacting with chromosomes or the microtubules of the other half spindle.
W Z, Cande, H J, Wein
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Male meiotic spindle features that efficiently segregate paired and lagging chromosomes
eLife, 2020 Chromosome segregation during male meiosis is tailored to rapidly generate multitudes of sperm. Little is known about mechanisms that efficiently partition chromosomes to produce sperm.
Gunar Fabig +9 more
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Pathogenic mutations in the chromokinesin KIF22 disrupt anaphase chromosome segregation
eLife, 2022 The chromokinesin KIF22 generates forces that contribute to mitotic chromosome congression and alignment. Mutations in the α2 helix of the motor domain of KIF22 have been identified in patients with abnormal skeletal development, and we report the ...
Alex F Thompson +7 more
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A Regulatory Switch Alters Chromosome Motions at the Metaphase-to-Anaphase Transition
Cell Reports, 2016 To achieve chromosome segregation during mitosis, sister chromatids must undergo a dramatic change in their behavior to switch from balanced oscillations at the metaphase plate to directed poleward motion during anaphase.
Kuan-Chung Su +5 more
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Bub1-mediated adaptation of the spindle checkpoint. [PDF]
PLoS Genetics, 2011 During cell division, the spindle checkpoint ensures accurate chromosome segregation by monitoring the kinetochore-microtubule interaction and delaying the onset of anaphase until each pair of sister chromosomes is properly attached to microtubules.
Greicy H Goto +4 more
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Anaphase B Precedes Anaphase A in the Mouse Egg [PDF]
Current Biology, 2012 Segregation of chromosomes at the time of cell division is achieved by the microtubules and associated molecules of the spindle. Chromosomes attach to kinetochore microtubules (kMTs), which extend from the spindle pole region to kinetochores assembled upon centromeric DNA.
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Some assembly required: Redefining the mitotic checkpoint
Molecular & Cellular Oncology, 2017 The spindle assembly checkpoint (also known as the spindle or mitotic checkpoint) is a surveillance system that ensures fidelity of chromosome segregation.
John C. Meadows, Jonathan B. A. Millar
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