Results 11 to 20 of about 137,810 (238)
Single-motor and multi-motor motility properties of kinesin-6 family members
Biology Open, 2022 Kinesin motor proteins are responsible for orchestrating a variety of microtubule-based processes including intracellular transport, cell division, cytoskeletal organization, and cilium function.
Andrew Poulos +2 more
doaj +1 more source
Cell Reports, 2021 Summary Micronuclei are a hallmark of cancer and several other human disorders. Recently, micronuclei were implicated in chromothripsis, a series of massive genomic rearrangements that may drive tumor evolution and progression.
B. Orr +6 more
semanticscholar +1 more source
Kinetochore life histories reveal an Aurora-B-dependent error correction mechanism in anaphase
Developmental Cell, 2021 Summary Chromosome mis-segregation during mitosis leads to aneuploidy, which is a hallmark of cancer and linked to cancer genome evolution. Errors can manifest as “lagging chromosomes” in anaphase, although their mechanistic origins and likelihood of ...
Onur Sen +3 more
semanticscholar +1 more source
Mechanical Mechanisms of Chromosome Segregation
Cells, 2021 Chromosome segregation—the partitioning of genetic material into two daughter cells—is one of the most crucial processes in cell division. In all Eukaryotes, chromosome segregation is driven by the spindle, a microtubule-based, self-organizing ...
Maya I. Anjur-Dietrich +2 more
doaj +1 more source
eLife, 2022 During anaphase B, molecular motors slide interpolar microtubules to elongate the mitotic spindle, contributing to the separation of chromosomes. However, sliding of antiparallel microtubules reduces their overlap, which may lead to spindle breakage ...
Manuel Lera-Ramirez +2 more
doaj +1 more source
Frontiers in Molecular Biosciences, 2021 In normal anaphase cells, telomeres of each separating chromosome pair are connected to each other by tethers. Tethers are elastic at the start of anaphase: arm fragments cut from anaphase chromosomes in early anaphase move across the equator to the ...
Arthur Forer +7 more
doaj +1 more source
Structural evidence for elastic tethers connecting separating chromosomes in crane-fly spermatocytes
Life Science Alliance, 2023 Correlative live imaging with electron tomography provides evidence that physical filamentous connections extend between separating telomeres at all stages of anaphase.
Arthur Forer, Shotaro Otsuka
doaj +1 more source
eLife, 2022 Chromosome segregation requires both the separation of sister chromatids and the sustained condensation of chromatids during anaphase. In yeast cells, cohesin is not only required for sister chromatid cohesion but also plays a major role determining the ...
Jonay Garcia-Luis +4 more
doaj +1 more source
PLoS Genetics, 2021 The spindle assembly checkpoint (SAC) prevents anaphase onset in response to chromosome attachment defects, and SAC silencing is essential for anaphase onset. Following anaphase onset, activated Cdc14 phosphatase dephosphorylates the substrates of cyclin-
Michael Bokros +3 more
doaj +1 more source
Ubc1 turnover contributes to the spindle assembly checkpoint in Saccharomyces cerevisiae
G3: Genes, Genomes, Genetics, 2021 The spindle assembly checkpoint protects the integrity of the genome by ensuring that chromosomes are properly attached to the mitotic spindle before they are segregated during anaphase.
Heather E Arsenault +8 more
doaj +1 more source