Results 101 to 110 of about 134,346 (229)

Modulation of Anaphase‐Promoting Complex Genes Regulates Root‐Knot Nematode Gall Development and Plant Susceptibility

open access: yesPlant, Cell &Environment, EarlyView.
ABSTRACT The anaphase‐promoting complex/cyclosome (APC/C) is a multi‐subunit E3 ubiquitin ligase that regulates cell cycle progression, but its role in plant‐pathogen interactions is poorly understood. Here, we demonstrate that regulation of the ubiquitin–proteasome system, involving APC/C‐associated components, is critical for coordinating host cell ...
Aline Köhn Carneiro   +8 more
wiley   +1 more source

Aberrant meiotic behavior in Agave tequilana Weber var. azul

open access: yesBMC Plant Biology, 2002
Background Agave tequilana Weber var. azul, is the only one variety permitted by federal law in México to be used for tequila production which is the most popular contemporary alcoholic beverage made from agave and recognized worldwide.
Rodríguez-Garay Benjamin   +1 more
doaj   +1 more source

Molecular Links Between Heat Stress and DNA Damage Response in Plants

open access: yesPlant, Cell &Environment, EarlyView.
ABSTRACT Climate change poses a major threat to agricultural productivity and, consequently, to global food security. Among the consequences of climate change, heat stress (HS) has emerged as a critical factor limiting crop performance. This has stimulated extensive research over the past decade to elucidate the molecular and physiological mechanisms ...
Adrian Calves‐Ubach   +1 more
wiley   +1 more source

Beta‐Arrestin‐2 Binds to Nucleolar Organizing Regions With P2X7 Receptor Stimulation and During Cell Division

open access: yesThe FASEB Journal, Volume 40, Issue 19, 15 October 2026.
Beta‐Arrestin‐2 but not Beta‐Arrestin‐1 can accumulate in the nucleolus and come in close contact with the Nucleolar Organizing Regions during two distinct processes: P2X7 receptor stimulation (A) and cell division (B). Both seem to be due to loss of nuclear membrane barrier that keeps Beta‐arrestin‐2 out of the nucleus.
Tuğba Gümüştaş   +4 more
wiley   +1 more source

Cyclin B3 activates the Anaphase-Promoting Complex/Cyclosome in meiosis and mitosis.

open access: yesPLoS Genetics, 2020
In mitosis and meiosis, chromosome segregation is triggered by the Anaphase-Promoting Complex/Cyclosome (APC/C), a multi-subunit ubiquitin ligase that targets proteins for degradation, leading to the separation of chromatids.
Damien Garrido   +5 more
doaj   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

open access: yesMolecular Oncology, Volume 20, Issue 10, Page 2490-2509, October 2026.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Crosstalk Between Parkinson's Disease and Colorectal Cancer: Genetic Mechanisms, Gut Microbiota, and Therapeutic Insights

open access: yesHealth Care Science, Volume 5, Issue 5, Page 495-513, October 2026.
This review elucidates the crosstalk between Parkinson's disease and colorectal cancer, driven by shared genetics (PRKN, PINK1, DJ‐1) involving oxidative stress, cell cycle regulation, and inflammation. It identifies the gut microbiota—via functional amyloids and short‐chain fatty acids (SCFAs)—as a mechanistic bridge, offering insights for dual ...
Jiacheng Ying   +6 more
wiley   +1 more source

Dynamic SUMO remodeling drives a series of critical events during the meiotic divisions in Caenorhabditis elegans.

open access: yesPLoS Genetics, 2018
Chromosome congression and segregation in C. elegans oocytes depend on a complex of conserved proteins that forms a ring around the center of each bivalent during prometaphase; these complexes are then removed from chromosomes at anaphase onset and ...
Amanda C Davis-Roca   +3 more
doaj   +1 more source

2‐Chloro‐5‐(trifluoromethyl)aniline‐Derived Schiff Base Palladium(II) Complexes: From Molecular Design to Acute Toxicity Assessment

open access: yesChemistryOpen, Volume 15, Issue 10, October 2026.
Four new Schiff bases derived from 2‐chloro‐5‐(trifluoromethyl)aniline and their corresponding palladium(II) complexes were obtained and analyzed by multiple spectroscopic techniques. Single‐crystal X‐ray diffraction elucidated the structures of all the ligands and complexes 2 and 4. Their toxicity was assessed on Triticum aestivum L.
Andreea Elena Ştefan   +10 more
wiley   +1 more source

Anaphase Analysis of CHO–M10

open access: yes, 2013
Cells were treated with 20 μM 5-aza-dC for a period of 3 d.(A) An untreated control cell undergoing normal anaphase, hybridized with M10-specific FISH probe to show correctly segregated M10 neocentromere (blue-green, filled arrowheads).(B and C) 5-aza-dC–
Nicholas C Wong (14627)   +7 more
core   +1 more source

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