Results 111 to 120 of about 66,778 (245)

Lysine demethylase 4A is a centrosome‐associated protein required for centrosome integrity and genomic stability

open access: yesThe FEBS Journal, EarlyView.
KDM4A, a chromatin eraser, localizes to the centrosomes. Its demethylase activity is essential for maintaining centrosome number and integrity, independent of gene expression changes. Loss of KDM4A leads to centrosome amplification, pseudo‐bipolar spindle formation, and chromosome segregation errors, including micronuclei and chromatin bridges.
Pratim Chowdhury   +16 more
wiley   +1 more source

DNA damage in mitosis: SOD1 delays anaphase onset

open access: yesThe FEBS Journal, EarlyView.
Mitotic cells do not exhibit a DNA damage checkpoint delay and do not repair DNA double strand breaks (DSBs) until the next cell cycle. Instead, DSBs can delay anaphase through the mitotic spindle checkpoint, by an incompletely understood mechanism. Li et al.
George Zachos
wiley   +1 more source

On the Anaphase Movement of Chromosomes [PDF]

open access: yesProceedings of the National Academy of Sciences, 1942
Hilda Vilkomerson, M. M. Rhoades
openaire   +2 more sources

Mycobacterium avium Subsp. paratuberculosis and Human Endogenous Retrovirus in Italian Patients With Inflammatory Bowel Disease (IBD) and Irritable Bowel Syndrome (IBS)

open access: yesImmunology, EarlyView.
Inflammatory bowel disease (IBD), comprising ulcerative colitis (UC) and Crohn's disease (CD), is a recognised gastrointestinal disorder. Mycobacterium avium subspecies paratuberculosis (MAP) is implicated in IBD pathogenesis. Persistent exposure and active infections by MAP may contribute to the unsilencing of human endogenous retroviruses (HERV ...
Stefano Ruberto   +14 more
wiley   +1 more source

Editing a gibberellin receptor gene improves yield and nitrogen fixation in soybean

open access: yesJournal of Integrative Plant Biology, EarlyView.
Knockout of the soybean gibberellin receptor gene GmGID1‐2 reduced plant height; strengthened stems; increased the number of branches, nodes, pods, and seeds; and improved yield, seed oil content and nitrogen fixation. ABSTRACT Soybean is an important source of oil, protein, and feed. However, its yield is far below that of major cereal crops.
Jiajun Tang   +11 more
wiley   +1 more source

PLK4 is a potential therapeutic target in nonmelanoma skin cancers: Evidence from molecular and in vivo studies

open access: yesPhotochemistry and Photobiology, EarlyView.
Exposure to solar ultraviolet radiation is the main etiologic driver of nonmelanoma skin cancers (NMSCs), including basal cell (BCC) and cutaneous squamous cell carcinomas (cSCC), which are the most prevalent types of cancers in the US. In this study, we demonstrate that the serine/threonine kinase Polo‐like kinase 4 (PLK4) is overexpressed in NMSCs ...
Mary A. Ndiaye   +5 more
wiley   +1 more source

MEPDB: Database of microExons in plants

open access: yesNew Phytologist, Volume 248, Issue 1, Page 32-37, October 2025.
Summary Microexons, ≤ 51‐nucleotide (nt), particularly ultra‐short ones (1–15 nt), are challenging to identify due to their small size and frequent absence in genome annotations, which limits understanding of their biological roles. Using our developed pipeline, we identified 2398 small internal microexons across 10 diverse plant species, and most of ...
Yakub Islamov   +3 more
wiley   +1 more source

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