Results 151 to 160 of about 78,527 (313)

The dynamics of replication licensing in live Caenorhabditis elegans embryos [PDF]

, 2012
Accurate DNA replication requires proper regulation of replication licensing, which entails loading MCM-2-7 onto replication origins. In this paper, we provide the first comprehensive view of replication licensing in vivo, using video microscopy of ...
Anton Gartner, Ashley Craig, Baldinger, Blow, Blow, Brauchle, Brenner, Cheeseman, Chen, Clarey, Clarey, DePamphilis, Drury, Edgar, Encalada, Evrin, Galy, Gambus, Gillespie, Hadwiger, Harvey, Ilves, J. Julian Blow, Kamath, Kim, Kisielewska, Korzelius, Kuipers, Li, Li, Li, Liu, Matthieu Querenet, McNairn, McNally, Moyer, Oehlmann, Praitis, Prokhorova, Quinn, Randell, Remi Sonneville, Remus, Rothbauer, Rowles, Shelton, Siddiqui, Speck, Sönnichsen, Tada, Timmons, Waga, Wallenfang, Wohlschlegel, Yanagi, Yang, Zhong   +56 more
core   +3 more sources

Cyclin B3 activates the Anaphase-Promoting Complex/Cyclosome in meiosis and mitosis.

PLoS Genetics, 2020
In mitosis and meiosis, chromosome segregation is triggered by the Anaphase-Promoting Complex/Cyclosome (APC/C), a multi-subunit ubiquitin ligase that targets proteins for degradation, leading to the separation of chromatids.
Damien Garrido, Mohammed Bourouh, Éric Bonneil, Pierre Thibault, Andrew Swan, Vincent Archambault   +5 more
doaj   +1 more source

Gibberellin signalling mediates nucleocytoplasmic trafficking of Sucrose Synthase 1 to regulate the drought tolerance in rice

Plant Biotechnology Journal, EarlyView.
Summary The Green Revolution (GR) has substantially improved cereal crop yields and enhanced adaptation to diverse environmental challenges. However, the molecular and cellular mechanisms involving GR‐related genes that regulate drought tolerance in plants remain largely unclear.
Jishuai Huang, Bin Xie, Fengjun Xian, Kejia Liu, Qian Yan, Yurong He, Lin Zhu, Wei Liu, Yue Jiang, Yuting Chen, Leilei Peng, Yuwei Zhou, Jun Hu   +12 more
wiley   +1 more source

Splicing factors Sf3A2 and Prp31 have direct roles in mitotic chromosome segregation [PDF]

, 2018
Several studies have shown that RNAi-mediated depletion of splicing factors (SFs) results in mitotic abnormalities. However, it is currently unclear whether these abnormalities reflect defective splicing of specific pre-mRNAs or a direct role of the SFs ...
Alushin, Antrobus, Auckland, Beyer, Blower, Blower, Bobkov, Bonaccorsi, Buffin, Burns, Buttrick, Chase, Ciferri, Conduit, De Renzis, DeLuca, DeLuca, Feijão, Giansanti, Giansanti, Giansanti, Giet, Goshima, Goto, Grenfell, Grenfell, Guilgur, Hanisch, Harel, Hayward, Heeger, Helgeson, Herold, Hofmann, Hofmann, Huranová, Janczyk, Khodor, Kiseleva, Kittler, Lehner, Liu, Maslon, Montembault, Neumann, Nguyen, Pacheco, Peretz, Przewloka, Raffa, Renda, Rogers, Roscioli, Rošić, Schittenhelm, Schweizer, Sharp, Shin, Silljé, Somma, Somma, Sundaramoorthy, Tadros, Takenaka, Tanenbaum, Toso, van der Lelij, Varma, Venkei, Vernì, Walker, Williams, Williams, Wu, Zalokar   +74 more
core   +1 more source

Exploration of histone protein γ‐H2AX as a prognostic factor in soft tissue sarcomas and its association with biological behavior, immune cell environment and survival in leiomyosarcoma

International Journal of Cancer, Volume 156, Issue 11, Page 2237-2250, 1 June 2025.
What's new? The remarkably poor prognosis of metastasized soft tissue sarcoma (STS) has motivated a search for novel biomarkers and therapeutic approaches. A promising candidate biomarker is H2A histone family member X (H2AX), a key player in DNA damage detection and repair pathways.
Adrian Georg Simon, Su Ir Lyu, Anne Maria Schultheis, David Stahl, Nora Wuerdemann, Sebastian Walter, Lena Hieggelke, Reinhard Buettner, Christiane Josephine Bruns, Peer Eysel, Lars Mortimer Schiffmann, Karl Knipper, Peter Mallmann, Alexander Quaas, Roland Ullrich   +14 more
wiley   +1 more source

Sequestration of CDH1 by MAD2L2 prevents premature APC/C activation prior to anaphase onset

Journal of Cell Biology, 2013
MAD2L2 is rapidly degraded by APC/CCDC20 at the onset of anaphase, allowing release of sequestered CDH1 to activate the dephosphorylated APC/C.
T. Listovsky, J. Sale
semanticscholar   +1 more source

Cyto‐Genotoxic Assessment of Sulfoxaflor in Allium cepa Root Cells and DNA Docking Studies

Microscopy Research and Technique, Volume 88, Issue 5, Page 1521-1533, May 2025.
Cyto‐genotoxic Assessment of Sulfoxaflor in Allium cepa Root Cells and DNA Docking Studies. ABSTRACT Sulfoxaflor (SFX) is an insecticide that is commonly used for the control of sap‐feeding insects. Since SFX is extensively applied globally, it has been implicated in the substantial induction of environmental toxicity.
Recep Liman, Muhammad Muddassir Ali, Erman Salih İstifli, İbrahim Hakkı Ciğerci, Ümran Tınaz, Sidal Kırlangıç, Nejla Altay, Yudum Yeltekin Uğur   +7 more
wiley   +1 more source

Patronin mediates a switch from kinesin-13–dependent poleward flux to anaphase B spindle elongation

Journal of Cell Biology, 2013
Patronin counteracts KLP10A activity at spindle poles to stabilize microtubule minus ends and induce spindle elongation during anaphase B.
Haifeng Wang, I. Brust-Mascher, G. Civelekoglu-Scholey, J. Scholey   +3 more
semanticscholar   +1 more source

Multi‐Omic Evaluation of PLK1 Inhibitor—Onvansertib—In Colorectal Cancer Spheroids

Journal of Mass Spectrometry, Volume 60, Issue 5, May 2025.
ABSTRACT Polo‐like kinase 1 (Plk1) is a serine/threonine kinase involved in regulating the cell cycle. It is activated by aurora kinase B along with the cofactors Borealin, INCE, and survivin. Plk1 is involved in the development of resistances to chemotherapeutics such as doxorubicin, Taxol, and gemcitabine.
Brian D. Fries, Emily R. Sekera, Joseph H. Holbrook, Amanda B. Hummon   +3 more
wiley   +1 more source

Meiotic cellular rejuvenation is coupled to nuclear remodeling in budding yeast. [PDF]

, 2019
Production of healthy gametes in meiosis relies on the quality control and proper distribution of both nuclear and cytoplasmic contents. Meiotic differentiation naturally eliminates age-induced cellular damage by an unknown mechanism.
Chetlapalli, Keerthana, Goodman, Jay S, Jorgens, Danielle M, King, Grant A, McDonald, Kent L, Schick, Jennifer G, Ünal, Elçin   +6 more
core   +1 more source