Results 151 to 160 of about 167,277 (315)

The checkpoint delaying anaphase in response to chromosome monoorientation is mediated by an inhibitory signal produced by unattached kinetochores

Journal of Cell Biology, 1995
During mitosis in Ptk1 cells anaphase is not initiated until, on average, 23 +/- 1 min after the last monooriented chromosome acquires a bipolar attachment to the spindle--an event that may require 3 h (Rieder, C. L., A. Schultz, R. W.
C. Rieder, R. Cole, A. Khodjakov, G. Sluder   +3 more
semanticscholar   +1 more source

Ecotoxicological Evaluation of Organic Sunscreens Used Worldwide, Alone and in Mixture, on Terrestrial Plants

Environmental Toxicology, EarlyView.
ABSTRACT The environmental hazards of sunscreens are discussed worldwide. However, there are few ecotoxicological studies on these compounds alone for edaphic organisms, and none for their mixtures. Avobenzone (1 and 10 ng/L), octocrylene (10 and 100 μg/L), and oxybenzone (2 and 20 μg/L), alone and in binary combinations (between the lowest and the ...
Diego Espirito Santo, Edson Araújo de Almeida, Elisângela Dusman, A. C. Downs, Regiane da Silva Gonzalez, Osvaldo Valarini Junior, Ana Paula Peron   +6 more
wiley   +1 more source

Fin1-PP1 Helps Clear Spindle Assembly Checkpoint Protein Bub1 from Kinetochores in Anaphase

Cell Reports, 2016
Summary: The spindle assembly checkpoint (SAC) monitors chromosome attachment defects, and the assembly of SAC proteins at kinetochores is essential for its activation, but the SAC disassembly process remains unknown.
Michael Bokros, Curtis Gravenmier, Fengzhi Jin, Daniel Richmond, Yanchang Wang   +4 more
doaj   +1 more source

ACTION SPECTRA FOR MITOTIC SPINDLE DESTRUCTION AND ANAPHASE DELAY FOLLOWING IRRADIATION OF THE CYTOPLASM WITH AN ULTRAVIOLET MICROBEAM* [PDF]

, 1967
Darrell Q. Brown, Raymond E. Zirkle
openalex   +1 more source

In vitro reactivation of spindle elongation in fission yeast nuc2 mutant cells. [PDF]

, 1990
To investigate the mechanisms of spindle elongation and chromosome separation in the fission yeast Schizosaccharomyces pombe, we have developed an in vitro assay using a temperature-sensitive mutant strain, nuc2.
Cande, WZ, Hirano, T, Masuda, H, Yanagida, M   +3 more
core  

The checkpoint protein MAD2 and the mitotic regulator CDC20 form a ternary complex with the anaphase-promoting complex to control anaphase initiation.

Genes & Development, 1998
The spindle assembly checkpoint mechanism delays anaphase initiation until all chromosomes are aligned at the metaphase plate. Activation of the anaphase-promoting complex (APC) by binding of CDC20 and CDH1 is required for exit from mitosis, and APC has ...
G. Fang, Hongtao Yu, Hongtao Yu, M. Kirschner   +3 more
semanticscholar   +1 more source

Deletion of the Mis12C‐Binding Domain of CENP‐C Promotes Chromosomal Aneuploidy in Cutaneous Squamous Cell Carcinoma

Cancer Science, EarlyView.
M12BD deficiency increases a chromosomal aneuploidy, particularly trisomy of chromosomes 6 and 10. ABSTRACT CENP‐C, an essential component of the kinetochore, connects centromeric chromatin to the outer kinetochore, and thereby ensures accurate chromosome segregation.
Megumi Saito, Kazuhiro Okumura, Yurika Tokunaga, Sora Tanaka, Keisuke Otoyama, Yoshinori Hasegawa, Masatoshi Hara, Masakazu Hashimoto, Toshihiko Fujimori, Tatsuo Fukagawa, Yuichi Wakabayashi   +10 more
wiley   +1 more source

Are dicentric anaphase bridges formed by somatic recombination in X chromosome inversion heterozygotes of Drosophila melanogaster? [PDF]

, 1972
J. R. Merriam, Rolf Nöthiger, Antonio Garcı́a-Bellido   +2 more
openalex   +1 more source

YKT6 Is Essential for Male Fertility by Promoting Meiosis Progression During Spermatogenesis of Mice

Cell Proliferation, EarlyView.
Specifically ablating Ykt6 in pre‐meiotic germ cells and meiotic spermatocytes leads to complete sterility and meiotic arrest in conditional knockout male mice. YTK6 is required for stabilising intercellular bridges between spermatocytes due to its key role in maintaining protein homeostasis and vesicular transport‐dependent functions in spermatocytes,
Jie Cen, Xiaochen Yu, Ziqi Wang, Wenbo Liu, Jianze Xu, Qian Fang, Fei Gao, Yongzhi Cao, Hongbin Liu   +8 more
wiley   +1 more source

Detection of Anaphase Bridge Formation by Immunofluorescence Microscopy in Mammalian Cells

Bio-Protocol, 2016
The aim of this protocol is to provide a comprehensive description of the materials, equipment and reproducible methods to detect and analyze anaphase bridges in immunofluorescence microscopy using DAPI to detect cells that failed to completely segregate
Thomas Aschacher, Florian Enzmann
doaj   +1 more source