Results 161 to 170 of about 78,527 (313)

PI 3-kinase-dependent phosphorylation of Plk1–Ser99 promotes association with 14-3-3γ and is required for metaphase–anaphase transition

Nature Communications, 2013
Polo-like kinase 1 (Plk1) controls multiple aspects of mitosis and is activated through its phosphorylation at Thr210. Here we identify Ser99 on Plk1 as a novel mitosis-specific phosphorylation site, which operates independently of Plk1–Thr210 ...
Kousuke Kasahara, H. Goto, I. Izawa, T. Kiyono, N. Watanabe, S. Elowe, E. Nigg, M. Inagaki   +7 more
semanticscholar   +1 more source

SKA1 promotes oncogenic properties in oral dysplasia and oral squamous cell carcinoma, and augments resistance to radiotherapy

Molecular Oncology, Volume 19, Issue 4, Page 1054-1074, April 2025.
The mitosis‐related gene SKA1 was among 629 genes consistently dysregulated in OSCC across nine public gene expression datasets. In OSCC cell lines, SKA1 promoted proliferation and migration, enhanced radioresistance, and reduced radiation‐induced senescence.
Alexander Michael Grandits, Barbara Andrea Reinoehl, Renate Wagner, Peter Kuess, Franziska Eckert, Anna Sophie Berghoff, Thorsten Fuereder, Rotraud Wieser   +7 more
wiley   +1 more source

ACAT1‐Mediated ME2 Acetylation Drives Chemoresistance in Ovarian Cancer by Linking Glutaminolysis to Lactate Production

Advanced Science, Volume 12, Issue 14, April 10, 2025.
Chemotherapy reduces glucose transporter expression and glucose uptake in cancer cells, leading to decreased pyruvate levels. This decline prompts ACAT1‐mediated acetylation of ME2 at Lys156, enhancing ME2 activity and promoting lactate production from glutamine.
Cuimiao Zheng, Hao Tan, Gang Niu, Xi Huang, Jingyi Lu, Siqi Chen, Haoyuan Li, Jiayu Zhu, Zhou Zhou, Manman Xu, Chaoyun Pan, Junxiu Liu, Jie Li   +12 more
wiley   +1 more source

ACTION SPECTRA FOR MITOTIC SPINDLE DESTRUCTION AND ANAPHASE DELAY FOLLOWING IRRADIATION OF THE CYTOPLASM WITH AN ULTRAVIOLET MICROBEAM* [PDF]

, 1967
Darrell Q. Brown, Raymond E. Zirkle
openalex   +1 more source

Precocious activation of APC/C-Cdh1 at pre-anaphase causes genome instability [PDF]

, 2008
Faithful chromosome segregation and thereby accurate gene transmission are crucial for all organisms. Until proper attachment of the mitotic spindle to the kinetochore is established, the ubiquitin ligase (E3) Cdc20-activated APC/C (anaphase promoting ...
Asuka Suzuki, Ayumu Yamamoto, Kazuhiro Toda, Masahiro Uritani, Masaru Ueno, Takanori Ohyoshi, Takashi Ushimaru   +6 more
core   +1 more source

The checkpoint delaying anaphase in response to chromosome monoorientation is mediated by an inhibitory signal produced by unattached kinetochores

Journal of Cell Biology, 1995
During mitosis in Ptk1 cells anaphase is not initiated until, on average, 23 +/- 1 min after the last monooriented chromosome acquires a bipolar attachment to the spindle--an event that may require 3 h (Rieder, C. L., A. Schultz, R. W.
C. Rieder, R. Cole, A. Khodjakov, G. Sluder   +3 more
semanticscholar   +1 more source

Molecular mechanism of Mad2 conformational conversion promoted by the Mad2‐interaction motif of Cdc20

Protein Science, Volume 34, Issue 4, April 2025.
Abstract During mitosis, unattached kinetochores trigger the spindle assembly checkpoint by promoting the assembly of the mitotic checkpoint complex, a heterotetramer comprising Mad2, Cdc20, BubR1, and Bub3. Critical to this process is the kinetochore‐mediated catalysis of an intrinsically slow conformational conversion of Mad2 from an open (O‐Mad2 ...
Conny W. H. Yu, Elyse S. Fischer, Joe G. Greener, Jing Yang, Ziguo Zhang, Stefan M. V. Freund, David Barford   +6 more
wiley   +1 more source

THE BEHAVIOR OF STRONG AND WEAK CENTROMERES AT SECOND ANAPHASE OF DROSOPHILA MELANOGASTER [PDF]

, 1960
Mark Ptashne
openalex   +1 more source

Ovarian Endometrioma Disrupts Oocyte‐Cumulus Communication and Mitochondrial Function, With Melatonin Mitigating the Effects

Cell Proliferation, Volume 58, Issue 4, April 2025.
Diagram illustrating the impact of OEM on oocyte‐cumulus communication, showing reduced TZPs, mitochondrial dysfunction, increased oxidative stress, DNA damage, and apoptosis. Melatonin (MLT) treatment improves communication, enhances mitochondrial function, reduces DNA damage, and restores oocyte quality, offering insights into potential therapeutic ...
Lei Ge, Yali Yang, Yuqing Gao, Tianxia Xiao, Wakam Chang, Hefei Wang, Zhonglin Xiao, Jie Chen, Mengxia Li, Ming Yu, Ping Jin, Jian V. Zhang   +11 more
wiley   +1 more source

Are dicentric anaphase bridges formed by somatic recombination in X chromosome inversion heterozygotes of Drosophila melanogaster? [PDF]

, 1972
J. R. Merriam, Rolf Nöthiger, Antonio Garcı́a-Bellido   +2 more
openalex   +1 more source