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Conditional Localization Pharmacology Manipulates the Cell Cycle with Spatiotemporal Precision. [PDF]
J Am Chem SocDeng C +7 more
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Seminars in Cell & Developmental Biology, 2021
Anaphase A is the motion of recently separated chromosomes to the spindle pole they face. It is accompanied by the shortening of kinetochore-attached microtubules. The requisite tubulin depolymerization may occur at kinetochores, at poles, or both, depending on the species and/or the time in mitosis.
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Anaphase A is the motion of recently separated chromosomes to the spindle pole they face. It is accompanied by the shortening of kinetochore-attached microtubules. The requisite tubulin depolymerization may occur at kinetochores, at poles, or both, depending on the species and/or the time in mitosis.
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Cdc14-regulated midzone assembly controls anaphase B [PDF]
Journal of Cell Biology, 2007 Spindle elongation in anaphase of mitosis is a cell cycle-regulated process that requires coordination between polymerization, cross-linking, and sliding of microtubules (MTs).
Anton Khmelinskii +2 more
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Trends in Biochemical Sciences, 2005
Anaphase is the stage of the cell cycle in which duplicated chromosomes separate and move towards opposite poles of the cell. Although its chromosome movements have always been viewed as majestic, until recently anaphase lacked obvious landmarks of regulation.
Armand, de Gramont, Orna, Cohen-Fix
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Anaphase is the stage of the cell cycle in which duplicated chromosomes separate and move towards opposite poles of the cell. Although its chromosome movements have always been viewed as majestic, until recently anaphase lacked obvious landmarks of regulation.
Armand, de Gramont, Orna, Cohen-Fix
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Nocodazole pretreatment in anaphase selectively reduces anaphase B in PtK1 cells
Cell Motility, 1983AbstractDuring early anaphase PtK1 cells were briefly treated with the rapidly reversible microtubule (MT) poison nocodazole. This treatment abruptly stopped chromosome motion and effected a large decrease in spindle birefringence. On removal of the drug, chromosome to pole motion (anaphase A) returned, though at a lesser rate but not extent than ...
J A, Snyder, S I, Vogt, S L, McLelland
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Anaphase Inactivation of the Spindle Checkpoint
Science, 2006The spindle checkpoint delays cell cycle progression until microtubules attach each pair of sister chromosomes to opposite poles of the mitotic spindle. Following sister chromatid separation, however, the checkpoint ignores chromosomes whose kinetochores are attached to only one spindle pole, a state that activates the checkpoint prior to metaphase. We
William J, Palframan +4 more
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