Results 181 to 190 of about 154,428 (289)

E3 Ubiquitin Ligases: Structures, Biological Functions, Diseases, and Therapy

MedComm, Volume 6, Issue 12, December 2025.
E3 ligases function as critical regulators of cellular protein degradation, and their dysregulation is a core pathogenic mechanism in a wide array of human diseases, including cancer, cardiovascular conditions, neurodegenerative disorders, and autoimmune diseases.
Haochen Wang, Junbo Peng, Hongchan Li, Yuzhe Lan, Jing Guo, Qiang Qiu, Xuan Huang   +6 more
wiley   +1 more source

Direct Binding of CDC20 Protein Family Members Activates the Anaphase-Promoting Complex in Mitosis and G1 [PDF]

, 1998
Guowei Fang, Hongtao Yu, Marc W. Kirschner   +2 more
openalex   +1 more source

Parkinson's Disease and Cancer: Mechanistic Insights and Therapeutic Opportunities From Cancer Neuroscience

MedComm – Oncology, Volume 4, Issue 4, December 2025.
Parkinson's disease (PD) and glioma are neurological disorders with distinct and even opposing mechanisms: α‐synuclein deposition and neuronal loss in PD versus glial cell malignancy in glioma. Despite these differences, their contrasting pathologies highlight multiple therapeutic targets.
Tianli Pan, Lin Yuan, Ruoyang Zhao, Liting Lu, Yinghao Zhi, Yuying Li, Min Wu, Yongye Huang   +7 more
wiley   +1 more source

Identification of genomic regions associated with partial resistance to Aphanomyces root rot in pea

The Plant Genome, Volume 18, Issue 4, December 2025.
Abstract Root rot caused by Aphanomyces euteiches is a major concern in pea (Pisum sativum L.). The lack of other effective control strategies makes crucial the development of resistant varieties. Although partial resistance has been reported, its quantitative inheritance, the association of resistance‐linked genomic regions with unfavorable agronomic ...
Sara Rodriguez‐Mena, Maria Carlota Vaz Patto, Susana Trindade Leitão, Diego Rubiales, Mario González   +4 more
wiley   +1 more source

The two coiled-coil domains of the fission yeast kinesin-6 Klp9 are required for motor tetramerization and spindle elongation. [PDF]

MicroPubl Biol
Nguyen MT, Ji L, Tran PT.
europepmc   +1 more source

Accumulation of Substrates of the Anaphase-Promoting Complex (APC) during Human Cytomegalovirus Infection Is Associated with the Phosphorylation of Cdh1 and the Dissociation and Relocalization of APC Subunits

, 2007
Karen Tran, Jeffrey A. Mahr, Jiwon Choi, Jose G. Teodoro, Michael R. Green, Deborah H. Spector   +5 more
openalex   +2 more sources

A Novel Destruction Sequence Targets the Meiotic Regulator Spo13 for Anaphase-promoting Complex-dependent Degradation in Anaphase I [PDF]

, 2007
Matt Sullivan, David O. Morgan
openalex   +1 more source

Deletion of the Mis12C‐Binding Domain of CENP‐C Promotes Chromosomal Aneuploidy in Cutaneous Squamous Cell Carcinoma

Cancer Science, Volume 116, Issue 12, Page 3532-3539, December 2025.
M12BD deficiency increases a chromosomal aneuploidy, particularly trisomy of chromosomes 6 and 10. ABSTRACT CENP‐C, an essential component of the kinetochore, connects centromeric chromatin to the outer kinetochore, and thereby ensures accurate chromosome segregation.
Megumi Saito, Kazuhiro Okumura, Yurika Tokunaga, Sora Tanaka, Keisuke Otoyama, Yoshinori Hasegawa, Masatoshi Hara, Masakazu Hashimoto, Toshihiko Fujimori, Tatsuo Fukagawa, Yuichi Wakabayashi   +10 more
wiley   +1 more source

14,15-dihydroclerodin (C₂₄H₃₆O₇) induced cell cycle delay, antimitotic and cytotoxic effects in Allium cepa L. root tip cells. [PDF]

Sci Rep
Ghosh P, Roy S, Ray S.
europepmc   +1 more source

Nocodazole-Induced Expression and Phosphorylation of Anillin and Other Mitotic Proteins Are Decreased in DNA-Dependent Protein Kinase Catalytic Subunit-Deficient Cells and Rescued by Inhibition of the Anaphase-Promoting Complex/Cyclosome with proTAME but Not Apcin

, 2020
Pauline Douglas, Ruiqiong Ye, Suraj Radhamani, Alexander Cobban, Nicole P. Jenkins, Edward Bartlett, Jonathan Roveredo, Arminja N. Kettenbach, Susan P. Lees‐Miller   +8 more
openalex   +2 more sources