Results 271 to 280 of about 154,428 (289)
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Enzymology of the Anaphase‐Promoting Complex
2005The anaphase-promoting complex (APC) is an ubiquitin-protein ligase that promotes mitotic progression by catalyzing the ubiquitination of numerous proteins, including securin and cyclin. Its complex subunit composition and extensive regulation make the APC an active subject of investigation for both cell biologists and enzymologists.
Christopher W, Carroll, David O, Morgan
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The role of telomeres at anaphase
Chromosoma, 19621. Chromosomes ofAllium cepa, Tradescantia virginiana andT. paludosa were studied at mitosis in order to investigate the behavior of telomeres at anaphase. The studies were made in untreated fixed material, in cochicine treated cells, and in living staminal hairs. 2. InAllium cepa andT.
A. Lima-de-Faria, S. Bose
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Cohesin and Cdk1: an anaphase barricade
Nature Cell Biology, 2010Separation of sister chromatids at anaphase in metazoan cells requires only the cleavage of the kleisin subunit of centromeric cohesin, but efficient poleward movement of separated sisters requires the associated loss in Cdk1 activity. Activation of the anaphase-promoting complex/cyclosome ensures these events are coordinated.
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Rephrasing anaphase: separase FEARs shugoshin
Chromosoma, 2005Cleavage of the ring-like cohesin complex by separase triggers segregation of sister chromatids in anaphase. This simplistic model has recently been extended by exciting discoveries on three levels: regulation of anaphase by posttranslational modifications and the cohesin protector shugoshin; non-proteolytic roles of separase; and cohesin-independent ...
Stemmann, Olaf +2 more
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The anaphase promoting complex.
Cancer surveys, 1997We have proposed a preliminary model of how the anaphase promoting complex functions throughout the cell cycle, but despite the flurry of recent publications characterizing the APC--its components, regulation and substrate specificity--many fundamental questions remain to be answered.
A M, Page, P, Hieter
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