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The Events and Regulation of Anaphase Onset
1993Aneuploidy results from the mal-segregation of one or more chromosomes during mitosis or meiosis. It can occur from the non-disjunction of a chromosome, the complete failure of a chromosome to attach to the spindle, the assembly of a multipolar spindle, or the failure of a monooriented chromosome to achieve a bipolar attachment prior to chromatid ...
Greenfield Sluder, Conly L. Rieder
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The anaphase promoting complex/cyclosome: a machine designed to destroy
Nature reviews. Molecular cell biology, 2006J. Peters
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Subunits and Substrates of the Anaphase-Promoting Complex
Experimental Cell Research, 1999The initiation of anaphase and exit from mitosis depend on a ubiquitination complex called the anaphase-promoting complex (APC) or cyclosome. The APC is composed of more than 10 constitutive subunits and associates with additional regulatory factors in mitosis and during the G1 phase of the cell cycle.
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2014
Cdk1 is an important cell cycle regulator that, in association with different cyclin regulatory subunits, is responsible for signaling important cell cycle events in all eukaryotic cells. In budding yeast, inhibition of Cdk1 by selective deletion of cyclin subunits has been shown to prevent anaphase onset, suggesting that Cdk1 activity is critically ...
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Cdk1 is an important cell cycle regulator that, in association with different cyclin regulatory subunits, is responsible for signaling important cell cycle events in all eukaryotic cells. In budding yeast, inhibition of Cdk1 by selective deletion of cyclin subunits has been shown to prevent anaphase onset, suggesting that Cdk1 activity is critically ...
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Anaphase: a fortune-teller of genomic instability.
Current Opinion in Cell Biology, 2018Anna H. Bizard, I. Hickson
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Sister-chromatid separation at anaphase onset is promoted by cleavage of the cohesin subunit Scc1
Nature, 1999F. Uhlmann, F. Lottspeich, K. Nasmyth
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