Results 141 to 150 of about 96,097 (301)

Anaphylaxis

Ear, Nose & Throat Journal, 1996
G A, Friday, P, Fireman
openaire   +2 more sources

Questionnaire Survey on Loquat‐Induced Oral Allergy Syndrome in School Children in Yamanashi, Japan

Allergy, EarlyView.
Ayumi Shimamura, Reiji Kojima, Hiroki Ishii, Tomokazu Matsuoka, Hisatake Ikeda, Daiju Sakurai   +5 more
wiley   +1 more source

Development of Betalactam‐Predictor: A Clinical Decision Tool for Delabeling Low‐Risk Betalactam Allergy Patients. Initial Validation in Penicillin Allergy

Allergy, EarlyView.
BL‐Predictor has emerged as a new tool for delabeling penicillin allergy. External validation has shown a specificity of 93% for detecting low‐risk patients. This score could potentially reduce diagnostic costs and the negative consequences associated with incorrect antibiotic allergy labels.
Marina Labella, Rafael Nuñez, Inmaculada Doña, Julia Rodríguez de Guzmán, Esther Moreno, Lene Heise Garvey, Jose Julio Laguna, Annick Barbaud, Patrizia Bonnadona, Jonas Bredtoft Boel, Holger Mosbech, Giovanna Sfriso, Mariana Castells, Elizabeth Phillips, María José Torres   +14 more
wiley   +1 more source

Early Risk Assessment and Recognition of Allergies in Children: Rationale, Methodology, and Proposed Algorithms

Allergy, EarlyView.
ABSTRACT Background Atopic diseases—including atopic dermatitis (AD), food allergy (FA), allergic rhinitis (AR), and asthma—are the most common chronic conditions in childhood and adolescence, affecting up to 30% of the global population. In Germany alone, more than 2.1 million children and adolescents are affected.
E. Hamelmann, B. Schaub, K. Beyer, K. Blümchen, M. Gerstlauer, M. V. Kopp, L. Lange, S. Lau, N. Maison, H. Ott, S. M. Schmidt, T. Spindler, C. Traidl‐Hoffmann, C. Vogelberg   +13 more
wiley   +1 more source

Allergic Sensitization to Inhalant Allergens in the Upper Respiratory Tract—the B Cell Side

Allergy, EarlyView.
ABSTRACT Allergic diseases are on the rise worldwide, driven by respiratory epithelial barrier dysfunction that promotes sensitization to inhalant allergens such as pollen, dust mites, pet dander, and fungal spores. These antigens trigger IgE‐mediated immune responses that lead to diseases such as allergic rhinitis (AR) and asthma.
Ola Grimsholm, Mohammed Zghaebi, Bita Hambrecht, Tanja Kalic, Christopher C. Udoye, Rudolf Manz, Barbara Bohle, Katarzyna M. Sitnik, Julia Eckl‐Dorna, Heimo Breiteneder   +9 more
wiley   +1 more source

Novel Bispecific Engagers Targeting the CεmX Domain of mIgE‐Expressing Cells

Allergy, EarlyView.
We developed bispecific TCE & NKCE targeting the CεmX domain of mIgE to eliminate IgE‐producing cells. Both constructs demonstrated potent, specific, dose‐dependent cytotoxicity and selective immune activation in vitro. These results highlight their promise as off‐the‐shelf, potentially curative therapeutics for IgE‐associated allergic diseases ...
Constantin Möller, Julia Hambach, Alessa Zoe Schaffrath, Thomas Eden, Sophia Cichutek, Anna Josephine Gebhardt, Natalie Tode, Ronald Maitschke‐Rajasekharan, Philipp Lewe, Sharon Qi, Susanne Witt, Marie Eggers, Nicola M. Tomas, Friedrich Haag, Friedrich Koch‐Nolte, Boris Fehse, Kristoffer Riecken   +16 more
wiley   +1 more source

Polymeric α‐Hairpinin Allergens Induce a Functional Response via a Single Antibody

Allergy, EarlyView.
Gage O. Leighton, Taylor M. Cosey, Emmanuel R. De Diavoukana, Isabelle R. Lytle, Alexander C. Y. Foo, Lars C. Pedersen, Scott A. Gabel, Robert M. Petrovich, Min Shi, Venu Aruva, Paige Creeks, Joyce J. W. Wong, Jian Zhang, R. Stokes Peebles Jr., Derek Croote, Scott A. Smith, Geoffrey A. Mueller   +16 more
wiley   +1 more source

Structural Basis for Trivalent Cross‐Linking of a Patient‐Derived IgE Antibody by the Major Peanut Allergen Ara h 2.0201

Allergy, EarlyView.
Graphical The crystal structure of a major peanut allergen Ara h 2.0201 in a complex with a human‐derived IgE Fab fragment has been determined. The immunocomplex shows the trivalent binding of Fabs, creating a cross‐linked structure effective in the formation of large complexes on the surface of effector cells. Hydroxylation of proline has implications
Tarja Parkkinen, Heidi Heiniluoto, Janne Jänis, Kristiina Takkinen, Juha Rouvinen   +4 more
wiley   +1 more source

Clonal Mast Cell Disorders and Mutation Profile in Adults Initially Presenting with Mast Cell Activation (Anaphylaxis) versus Non-Anaphylactic Presentations: A Joint Allergy-Hematology Cohort. [PDF]

J Asthma Allergy
Pornsuthirat P, Owattanapanich W, Wongsa C, Thongngarm T, Sompornrattanaphan M.   +4 more
europepmc   +1 more source

Successful Application of the Mast Cell Activation Test in Immediate Hypersensitivity to Amoxicillin

Allergy, EarlyView.
This study included 28 amoxicillin‐allergic patients and 11 healthy exposed controls. Mast cells were differentiated from CD34+ progenitors over 8 weeks using cytokine cocktails. The mast cell activation test involved sensitization with patient or control sera and stimulation with free amoxicillin or G4/G5‐AXO dendrimers with successfully activated ...
Jose A. Céspedes, Clara Lebrón‐Martín, Lucía Vallecillos‐Azor, Pablo Torres, Amene Tesfaye Ayane, Gádor Bogas, María Salas, Adriana Ariza, María Isabel Montañez, María José Torres, Carlos José Aranda, Cristobalina Mayorga   +11 more
wiley   +1 more source