Results 141 to 150 of about 64,042 (297)

Novel Bispecific Engagers Targeting the CεmX Domain of mIgE‐Expressing Cells

Allergy, EarlyView.
We developed bispecific TCE & NKCE targeting the CεmX domain of mIgE to eliminate IgE‐producing cells. Both constructs demonstrated potent, specific, dose‐dependent cytotoxicity and selective immune activation in vitro. These results highlight their promise as off‐the‐shelf, potentially curative therapeutics for IgE‐associated allergic diseases ...
Constantin Möller, Julia Hambach, Alessa Zoe Schaffrath, Thomas Eden, Sophia Cichutek, Anna Josephine Gebhardt, Natalie Tode, Ronald Maitschke‐Rajasekharan, Philipp Lewe, Sharon Qi, Susanne Witt, Marie Eggers, Nicola M. Tomas, Friedrich Haag, Friedrich Koch‐Nolte, Boris Fehse, Kristoffer Riecken   +16 more
wiley   +1 more source

Questionnaire Survey on Loquat‐Induced Oral Allergy Syndrome in School Children in Yamanashi, Japan

Allergy, EarlyView.
Ayumi Shimamura, Reiji Kojima, Hiroki Ishii, Tomokazu Matsuoka, Hisatake Ikeda, Daiju Sakurai   +5 more
wiley   +1 more source

Successful Application of the Mast Cell Activation Test in Immediate Hypersensitivity to Amoxicillin

Allergy, EarlyView.
This study included 28 amoxicillin‐allergic patients and 11 healthy exposed controls. Mast cells were differentiated from CD34+ progenitors over 8 weeks using cytokine cocktails. The mast cell activation test involved sensitization with patient or control sera and stimulation with free amoxicillin or G4/G5‐AXO dendrimers with successfully activated ...
Jose A. Céspedes, Clara Lebrón‐Martín, Lucía Vallecillos‐Azor, Pablo Torres, Amene Tesfaye Ayane, Gádor Bogas, María Salas, Adriana Ariza, María Isabel Montañez, María José Torres, Carlos José Aranda, Cristobalina Mayorga   +11 more
wiley   +1 more source

Anaphylaxis

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ANAPHYLAXIS Anaphylaxis (-
Richet, Charles R.
core  

Effect of Intramuscular Adrenaline on Histamine‐Induced Hypotension: A Randomised Placebo‐Controlled Pilot Trial

Allergy, EarlyView.
Histamine infusions induce reproducible severe hypotension. Intramuscular adrenaline showed ‘supposedly therapeutic’ plasma concentrations but did not produce a sustained clinically relevant improvement in shock in the majority of recipients. These findings question adrenaline pharmacokinetic surrogate thresholds and support the need for faster and ...
Matthias Weiss‐Tessbach, Al Medina Dizdarevic, Thorsten Bischof, Christa Firbas, Alexander Taschner, Eva‐Luise Ritter‐Hobl, Barbara Steinlechner, Eva Fischer, Lorenz Sonnberger, Georg Gelbenegger, Jolanta M. Siller‐Matula, Christian Schoergenhofer, Bernd Jilma   +12 more
wiley   +1 more source

The Evolution of Sesame Seed Allergy Over Time

Allergy, EarlyView.
This study analyzes the natural history of sesame over time and the changes in biomarkers between sesame allergic and sesame sensitised but tolerant children. The period prevalence of sesame allergy increased from 0.5% between 12 and 36 m to 1.5% between 7 and 12 y children in the EAT‐On study with 10 children developing new sesame allergy. Sesame‐sIgE
Ru‐Xin Foong, George Du Toit, Henry T. Bahnson, Ronald van Ree, Suzana Radulovic, Serge A. Versteeg, Joanna Craven, Matthew Kwok, Zainab Jama, Helen A. Brough, Kirsty Logan, Michael R. Perkin, Carsten Flohr, Alexandra F. Santos, Gideon Lack   +14 more
wiley   +1 more source

Navigating Oral Food Challenges in Clinical Trials to Keep the Science Moving Forward

Allergy, EarlyView.
ABSTRACT The oral food challenge (OFC) has long been the reference standard for food allergy diagnosis, as well as to confirm natural development of oral tolerance. The utilization of OFCs has significantly broadened from its role in defining disease to defining participant eligibility, individual allergen reactivity thresholds and treatment outcomes ...
Edwin H. Kim, J. Andrew Bird, Helen A. Brough, David M. Fleischer, Stacie M. Jones, Ildiko Kun, Wayne Shreffler, Claire Van Eenwyk, Brian P. Vickery, Julie Wang, Alexandra F. Santos   +10 more
wiley   +1 more source

Polymeric α‐Hairpinin Allergens Induce a Functional Response via a Single Antibody

Allergy, EarlyView.
Gage O. Leighton, Taylor M. Cosey, Emmanuel R. De Diavoukana, Isabelle R. Lytle, Alexander C. Y. Foo, Lars C. Pedersen, Scott A. Gabel, Robert M. Petrovich, Min Shi, Venu Aruva, Paige Creeks, Joyce J. W. Wong, Jian Zhang, R. Stokes Peebles Jr., Derek Croote, Scott A. Smith, Geoffrey A. Mueller   +16 more
wiley   +1 more source

Frequency and Severity of Allergic Reactions to Non‐Mandatory Labelled Allergenic Foods—Data From Two Large European Cohorts

Allergy, EarlyView.
In two large European cohorts, 589 reactions to non‐mandatory labelled plant‐based foods were identified with sunflower seed, pine nut, pea and lentil as the most frequent triggers. Reaction severity was not different between mandatory and non‐mandatory labelled allergenic foods. Their frequency and rising trends (e.g., fenugreek, pumpkin seed) support
Sabine Dölle‐Bierke, Alejandro Gonzalo‐Fernández, Dominique Sabouraud‐Leclerc, Laura Barreales‐Tolosa, Barbara Ballmer‐Weber, Simona Belohlavkova, Maria B. Bilò, Ruta Dubakiene, Karin Hartmann, Monika Jedrzejczak‐Czechowicz, Thuy‐My Le, Lars Lange, Nikolaos G. Papadopoulos, Guillaume Pouessel, Isabel Reig, Athanasios Sinaniotis, E. N. Clare Mills, Margitta Worm, Montserrat Fernández‐Rivas   +18 more
wiley   +1 more source

Hypersensitivity to Excipients in Drugs: An EAACI Position Paper

Allergy, EarlyView.
ABSTRACT Drugs contain active pharmaceutical ingredients and excipients, compounds which enhance the pharmacokinetics, stability and palatability of the pharmaceutical formulation. While most drug hypersensitivity reactions (DHR) are caused by active ingredients, excipients may also be involved.
Lene H. Garvey, Knut Brockow, Annick Barbaud, Charlotte G. Mortz, Gianfranco Calogiuri, Asli Gelincik, Osman O. Yeğit, Alla Nakonechna, Annette Wagner, Rik Schrijvers, Toon Ieven   +10 more
wiley   +1 more source