Results 121 to 130 of about 113,928,477 (177)

[Studies on botulin anatoxins. IV. Botulin anatoxin type E].

Zhurnal mikrobiologii, epidemiologii i immunobiologii, 1998
A A, VOROB'EV, N N, VASIL'EV, L M, SAMORODOV, I V, VORONTSOV, G T, PATRIKEEV, M M, MAKARENKO   +5 more
openaire   +1 more source

Synthesis of (±)-Anatoxin-a and Analogues

Tetrahedron, 2000
A new and highly efficient synthesis of the potent nicotinic acetylcholine receptor agonist, anatoxin-a and its analogues is described, which uses a s-lactam ring opening-transannular cyclisation sequence to set up the bridged bicyclic framework of the natural product.
Philip Parsons
exaly   +3 more sources

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Biosynthesis of Anatoxins in Cyanobacteria: Identification of the Carboxy-anatoxins as the Penultimate Biosynthetic Intermediates

Journal of Natural Products, 2020
Anatoxin-a, homoanatoxin-a, and dihydroanatoxin-a are potent cyanobacterial neurotoxins. They are biosynthesized in cyanobacteria from proline and acetate by a pathway involving three polyketide synthases. We report the identification of carboxy-anatoxin-a, carboxy-homoanatoxin-a, and carboxy-dihydroanatoxin-a in acidic extracts of Cuspidothrix ...
Andreja Kust, Annick Méjean, Olivier Ploux   +2 more
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Biosynthesis of anatoxin-a and analogues (anatoxins) in cyanobacteria

Toxicon, 2014
Freshwater cyanobacteria produce secondary metabolites that are toxic to humans and animals, the so-called cyanotoxins. Among them, anatoxin-a and homoanatoxin-a are potent neurotoxins that are agonists of the nicotinic acetylcholine receptor. These alkaloids provoke a rapid death if ingested at low doses. Recently, the cluster of genes responsible for
Annick, Méjean, Guillaume, Paci, Valérie, Gautier, Olivier, Ploux   +3 more
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Anatoxin

Chemical Communications, 2014
Anatoxin-a (AN) and homoanatoxin (HMAN) are two powerful nicotinic agonists. Symptoms of AN and HMAN toxicosis include tremors, convulsions, muscle fasciculations, and rapid death due to respiratory failure. AN is unstable under natural conditions and is naturally degraded either partially or totally to the nontoxic products dihydroanatoxin-a and ...
Justine Dauphard, Mary Lehane, Frank van Pelt, John O'Halloran, Ambrose Furey   +4 more
openaire   +3 more sources

Anatoxin-a elicits an increase in peroxidase and glutathione S-transferase activity in aquatic plants

Aquatic Toxicology, 2004
Although the toxic effects of cyanotoxins on animals have been examined extensively, little research has focused on their effects on macrophytes and macroalgae. To date only microcystins have been found to be detrimental to aquatic plants.
Simon Mitrović, Stephan Pflugmacher, Ambrose Furey   +2 more
exaly   +2 more sources

Analysis of Anatoxin-a by GCIECD*

Journal of Analytical Toxicology, 1988
Anatoxin-a (ANTX-a), a potent cholinergic alkaloid produced by some toxigenic strains of the cyanobacterium Anabaena flos-aquae, has been responsible for death of livestock, pets, and wildlife. An increase in the frequency of cyanobacterial blooms in fresh waters of temperate North America has produced a concomitant increase in the threat posed by ...
D K, Stevens, R I, Krieger
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Synthesis of nor-anatoxin-a and anatoxin-a

Canadian Journal of Chemistry, 1977
The neuro-muscular post-synaptic depolarizing agent anatoxin-a from Anabaena flos-aquae (Lyngb.) de Bréb. has been synthesized from cocaine.
Henry F. Campbell, Oliver E. Edwards, Ralph Kolt   +2 more
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Conformational studies on (+)-anatoxin-a and derivatives

Journal of Computer-Aided Molecular Design, 1992
Anatoxin-a (AnTX) is a highly potent agonist acting at the nicotinic acetylcholine receptor (nAChR) and represents a valuable tool in the study of this receptor. Molecular mechanics, semi-empirical and ab initio molecular orbital energy minimization procedures were conducted to investigate the conformation of AnTX.
Philip E. Thompson, David T. Manallack, Frank E. Blaney, Timothy Gallagher   +3 more
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Homoanatoxin: A potent analogue of anatoxin-a

Biochemical Pharmacology, 1992
The natural toxin anatoxin-a (AnTx) is a potent nicotinic agonist that is valuable for the study of nicotinic receptors. We have synthesized 2-(propan-1-oxo-1-yl)-9-azabicyclo[4.2.1]non-2-ene, the homologue of AnTx in which the side-chain is extended by one methylene unit from a methyl to an ethyl ketone.
Wonnacott, S, Swanson, EL, Albuquerque, EX, Huby, NJS, Thompson, P, Gallagher, TC   +5 more
openaire   +2 more sources