Results 131 to 140 of about 113,928,477 (177)
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Mass Spectrometric Analysis of Anatoxin-a
Journal of Analytical Toxicology, 1989Secondary ion mass spectrometry (SIMS), gas chromatography/mass spectrometry (GC/MS), desorption chemical ionization/mass spectrometry (DCI/MS), and thermospray/mass spectrometry (TSP/MS) were evaluated for the detection of a low-molecular weight biological toxin, anatoxin-a.
M M, Ross, D A, Kidwell, J H, Callahan
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Revista Intertox de Toxicologia, Risco Ambiental e Sociedade, 2015
Current natural conditions as well as human activities have been promoting changes and increasing stress in the freshwater and marine environment. One of the consequences is the worldwide occurrence of cyanobacterial (blue-green algae) blooms, which is considered a serious environmental and economic problem (ARAOZ, et al 2005).
Vania Rodríguez, Ernani Pinto
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Current natural conditions as well as human activities have been promoting changes and increasing stress in the freshwater and marine environment. One of the consequences is the worldwide occurrence of cyanobacterial (blue-green algae) blooms, which is considered a serious environmental and economic problem (ARAOZ, et al 2005).
Vania Rodríguez, Ernani Pinto
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The Journal of Organic Chemistry, 1990
A straightforward and good yielding route to side-chain analogues of the potent neurotoxin and neurotransmitter (+)-anatoxin (1) has been developed. Peroxy acid oxidation of the (silyloxy)butadiene 43 derived from readily synthesized, optically pure (Ifl)-t-BOC-anatoxin (42) affords silyloxy ketone 44.
Michael H. Howard +2 more
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A straightforward and good yielding route to side-chain analogues of the potent neurotoxin and neurotransmitter (+)-anatoxin (1) has been developed. Peroxy acid oxidation of the (silyloxy)butadiene 43 derived from readily synthesized, optically pure (Ifl)-t-BOC-anatoxin (42) affords silyloxy ketone 44.
Michael H. Howard +2 more
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2000
Abstract Anatoxin-a is a bicyclic secondary amine isolated from at least three genera of freshwater cyanobacteria (blue-green algae) including Anabaena, Aphanizomenon, and Oscilla toria. Certain strains of Oscillatoria rubescens also produce a methylene homologue of anatoxin-a called homoanatoxin a (4). The structure of anatoxin-a was
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Abstract Anatoxin-a is a bicyclic secondary amine isolated from at least three genera of freshwater cyanobacteria (blue-green algae) including Anabaena, Aphanizomenon, and Oscilla toria. Certain strains of Oscillatoria rubescens also produce a methylene homologue of anatoxin-a called homoanatoxin a (4). The structure of anatoxin-a was
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The Journal of Organic Chemistry, 2005
[reaction: see text] This paper describes the total synthesis of the naturally occurring alkaloids pinnamine (1) and anatoxin-a (2) from a common enantiomerically pure intermediate (7) easily available from pyroglutamic acid. The synthesis of enantiopure pinnamine proceeded in 10 steps and 4.8% overall yield, and the route was flexible enough to allow ...
Thomas, Hjelmgaard +2 more
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[reaction: see text] This paper describes the total synthesis of the naturally occurring alkaloids pinnamine (1) and anatoxin-a (2) from a common enantiomerically pure intermediate (7) easily available from pyroglutamic acid. The synthesis of enantiopure pinnamine proceeded in 10 steps and 4.8% overall yield, and the route was flexible enough to allow ...
Thomas, Hjelmgaard +2 more
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An efficient synthesis of (+)-anatoxin-a.
Tetrahedron: Asymmetry, 1992Abstract An efficient synthesis (38 % overall yield in 8 steps starting from 2) of the potent neurotoxin (+)-anatoxin-a is described. The key step involves the stereoselective addition of 5-hexenylcopper to the chiral N-acyliminium ion 2a .
Marco Skrinjar +2 more
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Evaluation of the subacute toxicity and teratogenicity of anatoxin-a
Toxicon, 1980Abstract A sublethal dose in rats (i.p. and oral) had no effect on food consumption, growth, blood cells, serum enzymes or hepatic mixed function oxidase nor were morphological changes observed at necropsy. In hamsters there were no skeletal or soft tissue malformations, however, fetal stunting was observed.
N B, Astrachan +2 more
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A short and enantioselective synthesis of (+)-Anatoxin-a
Tetrahedron Letters, 1992Abstract A short and enantioselective total synthesis of the neurotoxic alkaloid (+)-Anatoxin-a ( 1 ) from the L-pyroglutamic acid derivative 2 is described. The key step involves an intramolecular cyclisation of an N-tosyl iminium ion derived from the corresponding α-methoxy sulfonamide.
Peter Somfai, Jens Åhman
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Toxic Effects Produced by Anatoxin-a under Laboratory Conditions: A Review
Toxins, 2022Angeles Mencía Jos Gallego +2 more
exaly