Results 131 to 140 of about 1,413 (181)
Some of the next articles are maybe not open access.
Synthesis of nor-anatoxin-a and anatoxin-a
Canadian Journal of Chemistry, 1977The neuro-muscular post-synaptic depolarizing agent anatoxin-a from Anabaena flos-aquae (Lyngb.) de Bréb. has been synthesized from cocaine.
Henry F. Campbell +2 more
openaire +1 more source
Homoanatoxin: A potent analogue of anatoxin-a
Biochemical Pharmacology, 1992The natural toxin anatoxin-a (AnTx) is a potent nicotinic agonist that is valuable for the study of nicotinic receptors. We have synthesized 2-(propan-1-oxo-1-yl)-9-azabicyclo[4.2.1]non-2-ene, the homologue of AnTx in which the side-chain is extended by one methylene unit from a methyl to an ethyl ketone.
Wonnacott, S +5 more
openaire +2 more sources
Mass Spectrometric Analysis of Anatoxin-a
Journal of Analytical Toxicology, 1989Secondary ion mass spectrometry (SIMS), gas chromatography/mass spectrometry (GC/MS), desorption chemical ionization/mass spectrometry (DCI/MS), and thermospray/mass spectrometry (TSP/MS) were evaluated for the detection of a low-molecular weight biological toxin, anatoxin-a.
M M, Ross, D A, Kidwell, J H, Callahan
openaire +2 more sources
Conformational studies on (+)-anatoxin-a and derivatives
Journal of Computer-Aided Molecular Design, 1992Anatoxin-a (AnTX) is a highly potent agonist acting at the nicotinic acetylcholine receptor (nAChR) and represents a valuable tool in the study of this receptor. Molecular mechanics, semi-empirical and ab initio molecular orbital energy minimization procedures were conducted to investigate the conformation of AnTX.
Philip E. Thompson +3 more
openaire +2 more sources
Revista Intertox de Toxicologia, Risco Ambiental e Sociedade, 2015
Current natural conditions as well as human activities have been promoting changes and increasing stress in the freshwater and marine environment. One of the consequences is the worldwide occurrence of cyanobacterial (blue-green algae) blooms, which is considered a serious environmental and economic problem (ARAOZ, et al 2005).
Vania Rodríguez, Ernani Pinto
openaire +1 more source
Current natural conditions as well as human activities have been promoting changes and increasing stress in the freshwater and marine environment. One of the consequences is the worldwide occurrence of cyanobacterial (blue-green algae) blooms, which is considered a serious environmental and economic problem (ARAOZ, et al 2005).
Vania Rodríguez, Ernani Pinto
openaire +1 more source
The Journal of Organic Chemistry, 2005
[reaction: see text] This paper describes the total synthesis of the naturally occurring alkaloids pinnamine (1) and anatoxin-a (2) from a common enantiomerically pure intermediate (7) easily available from pyroglutamic acid. The synthesis of enantiopure pinnamine proceeded in 10 steps and 4.8% overall yield, and the route was flexible enough to allow ...
Thomas, Hjelmgaard +2 more
openaire +2 more sources
[reaction: see text] This paper describes the total synthesis of the naturally occurring alkaloids pinnamine (1) and anatoxin-a (2) from a common enantiomerically pure intermediate (7) easily available from pyroglutamic acid. The synthesis of enantiopure pinnamine proceeded in 10 steps and 4.8% overall yield, and the route was flexible enough to allow ...
Thomas, Hjelmgaard +2 more
openaire +2 more sources
2000
Abstract Anatoxin-a is a bicyclic secondary amine isolated from at least three genera of freshwater cyanobacteria (blue-green algae) including Anabaena, Aphanizomenon, and Oscilla toria. Certain strains of Oscillatoria rubescens also produce a methylene homologue of anatoxin-a called homoanatoxin a (4). The structure of anatoxin-a was
openaire +1 more source
Abstract Anatoxin-a is a bicyclic secondary amine isolated from at least three genera of freshwater cyanobacteria (blue-green algae) including Anabaena, Aphanizomenon, and Oscilla toria. Certain strains of Oscillatoria rubescens also produce a methylene homologue of anatoxin-a called homoanatoxin a (4). The structure of anatoxin-a was
openaire +1 more source
Gaston Ramon (to Centenary of the discovery of anatoxins)
Problems of Social Hygiene Public Health and History of Medicine, 2023In the history of science, there are great scientists who, without being physicians, wrote golden pages in the History of Medicine. Such was Louis Pasteur, founder of scientific microbiology and immunology. Such was his follower Gaston Ramon (1886-1963), French veterinarian and immunologist who created 100 years ago first anatoxin for active prevention
A E, Ershov +2 more
openaire +2 more sources
The Journal of Organic Chemistry, 1990
A straightforward and good yielding route to side-chain analogues of the potent neurotoxin and neurotransmitter (+)-anatoxin (1) has been developed. Peroxy acid oxidation of the (silyloxy)butadiene 43 derived from readily synthesized, optically pure (Ifl)-t-BOC-anatoxin (42) affords silyloxy ketone 44.
Michael H. Howard +2 more
openaire +1 more source
A straightforward and good yielding route to side-chain analogues of the potent neurotoxin and neurotransmitter (+)-anatoxin (1) has been developed. Peroxy acid oxidation of the (silyloxy)butadiene 43 derived from readily synthesized, optically pure (Ifl)-t-BOC-anatoxin (42) affords silyloxy ketone 44.
Michael H. Howard +2 more
openaire +1 more source
An efficient synthesis of (+)-anatoxin-a.
Tetrahedron: Asymmetry, 1992Abstract An efficient synthesis (38 % overall yield in 8 steps starting from 2) of the potent neurotoxin (+)-anatoxin-a is described. The key step involves the stereoselective addition of 5-hexenylcopper to the chiral N-acyliminium ion 2a .
Marco Skrinjar +2 more
openaire +1 more source