Results 111 to 120 of about 8,073,410 (232)

Heterogeneity of injury in vasculitis: influence of anti neutrophil cytoplasm antibody IgG subclass and endothelial susceptibility. [PDF]

, 2010
This study examined IgG subclass in ANCA associated vasculitis and glomerular endothelial cell (GEC) phenotype predisposes to injury. Using the flow model, interaction of neutrophils with normal immunoglobulin subclasses was compared to interaction with ...
Pankhurst, Tanya
core   +3 more sources

Similarities and Differences Between Patients Diagnosed with ANCA-Associated Vasculitis Who Are Positive and Negative for ANCA: University Clinic Practice and Expertise

Medicina
Background and objective. Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) affects small- to medium-sized vessels and is characterized by the production of ANCAs. The ANCA-negative term is used if the patient otherwise fulfills the
Giedre Dereseviciene, Jolanta Dadoniene, Dalia Miltiniene   +2 more
doaj   +1 more source

When to consider an inborn error of immunity: clues for physicians

Internal Medicine Journal, Volume 56, Issue 9, Page 1488-1499, September 2026.
Abstract The term inborn errors of immunity (IEIs) refers to the rapidly expanding group of genetic disorders causing dysregulation of the immune system. With improved genetic testing in recent years, the number of defined IEIs and their range of phenotypic presentations has grown vastly, with more than 550 IEIs now described.
Meera Thangarajah, Lucinda J. Berglund
wiley   +1 more source

Complement Activation by Post‐Translationally Modified Proteins: Links to Chronic Inflammation and Autoimmunity

Immunological Reviews, Volume 342, Issue 1, September 2026.
ABSTRACT Post‐translational modifications (PTMs) of proteins are essential to maintain homeostasis as many cellular processes rely on reversible PTMs. However, several PTMs, particularly irreversible PTMs in the extracellular space, can contribute to tissue dysfunction, inflammation, and may even trigger the development of autoimmunity against PTM ...
Marleen M. J. van Greevenbroek, Leendert A. Trouw   +1 more
wiley   +1 more source

Vasculitis por Propiltiouracilo: reporte de un caso

Acta Médica Costarricense, 2002
Se reporta el caso clínico de una paciente femenina de 43 años que presentó dos complicaciones secundarias al uso de propiltiouracilo: vasculitis y agranulocitosis.La vasculitis asociada con el tratamiento antitiroideo es una entidad clínica bien ...
Donato A. Salas-Segura, Juan I. Padilla-Cuadra, Juliana Salas-Segura   +2 more
doaj  

Mapping the Altered Landscape of TCR Repertoire in Autoimmune Diseases

Immunological Reviews, Volume 342, Issue 1, September 2026.
ABSTRACT Autoimmune diseases arise from the breakdown of immune tolerance through complex interactions between genetic predisposition, environmental exposures, and adaptive immune responses. High‐throughput T‐cell receptor (TCR) repertoire sequencing has transformed our ability to characterize these responses, providing unprecedented insights into ...
Celine Albalaa, Martin Pezous, David Klatzmann, Encarnita Mariotti‐Ferrandiz   +3 more
wiley   +1 more source

Acute Fulminant Systemic Granulocytic Vasculitis Involving Arteries and Veins in Vacuoles, E1 Enzyme, X‐Linked, Autoinflammatory, Somatic (VEXAS) Syndrome: An Autopsy Case Report

Pathology International, Volume 76, Issue 9, September 2026.
We report an autopsy case of VEXAS syndrome presenting with aggressive clinical course. Pathologically, the disease manifested as systemic granulocytic vasculitis affecting both arteries and veins, characterized by the presence of histiocytoid myeloid cells associated with low‐risk MDS.
Kayo Ueda, Masakazu Fujimoto, Yumi Shiroishi, Masafumi Ito, Masahiko Osawa, Mayumi Inaba   +5 more
wiley   +1 more source

The Src‐Family Kinases Hck, Fgr and Lyn Drive Immune Complex‐Mediated Glomerulonephritis Through the Syk Tyrosine Kinase

The FASEB Journal, Volume 40, Issue 16, 31 August 2026.
The study aimed to test the role of three Src‐family kinases, Hck, Fgr, and Lyn in immune complex glomerulonephritis. Hck, Fgr, and Lyn were overexpressed in human lupus nephritis and mouse nephrotoxic nephritis. Combined genetic deficiency of the three kinases practically completely protected mice from nephrotoxic nephritis.
Lukács S. Lesinszki, Dorottya Deli, Lili K. Boldizsár, Áron Pánczél, Attila Fintha, Michael G. Robson, Attila Mócsai   +6 more
wiley   +1 more source

Pharmacogenetics of rituximab in anca-associated vasculitis

, 2017
Background: Rituximab is effective for induction and maintenance of remission in ANCA-associated vasculitis; however, response to treatment is highly variable and relapse is common after its discontinuation. Biomarkers predicting response to rituximab do
Alberici, Federico
core   +2 more sources

Extreme thrombocytosis and ANCA-associated vasculitis in an adult patient: a case report

BMC Rheumatology
Introduction We describe the case of a 39-year-old woman who presented with extreme reactive thrombocytosis as a prominent and unusual feature in the context of anti-neutrophil cytoplasmic antibody (myeloperoxidase, MPO)-associated vasculitis.
Andrés Hormaza-Jaramillo, Maria J. Varela, Daniela Peñaloza Gonzalez, Sara Alejandra Benavides-Ibarra, Carlos Jimenez, David Aguirre-Valencia   +5 more
doaj   +1 more source