Results 131 to 140 of about 88,572 (244)

Characteristics and Outcomes of Male Participants in a Multicenter Longitudinal Australian Study Cohort

open access: yesArthritis Care &Research, Volume 78, Issue 11, Page 1701-1710, November 2026.
Objective The aim of this study was to determine the differences in demographic, serologic, and clinical characteristics between male and female patients with systemic sclerosis (SSc) in an Australian cohort. Methods This was a retrospective observational study using data from the Australian Scleroderma Cohort Study.
Emily Lin   +14 more
wiley   +1 more source

Severe ADEM‐Like Neuroinflammatory Disease and Cerebrovascular Fragility With Recurrent Pseudoaneurysms and Moyamoya in a Familial Germline CBL Mutation: Expanding the Clinical Phenotype

open access: yesAmerican Journal of Medical Genetics Part A, Volume 200, Issue 11, Page 2568-2574, November 2026.
ABSTRACT Heterozygous germline variants in CBL disrupt its function as a negative regulator of the Ras/MAPK pathway, classically predisposing to Juvenile myelomonocytic leukemia (JMML) and moyamoya. We describe two affected siblings carrying a paternally inherited CBL variant (c.1210 T> C, p.
Michal Bar‐Hakim   +12 more
wiley   +1 more source

Comparison of perinuclear (P-ANCA) and cytoplasmic (C-ANCA) anti-neutrophil cytoplasmic antibodies and ANCA against proteinase 3 (PR3) and myeloperoxidase (MPO) levels by classical and automated multiplex microbead assay analysis in one reaction environment.

open access: yes, 2014
PR3- and MPO-ANCA were determined by enzyme-linked immunosorbent assay (ELISA) and multiplex CytoBead microbead assay in 118 patients with ANCA-associated vasculitis, 300 with autoimmune and gastrointestinal diseases, 49 with infectious disorders, and ...
Rico Hiemann (355810)   +13 more
core   +1 more source

Tubulointerstitial Nephritis With Uveitis Syndrome: A Case Report and Review of Literature

open access: yesClinical Case Reports, Volume 14, Issue 11, November 2026.
ABSTRACT TINU syndrome should be considered in any child presenting with unexplained renal dysfunction and uveitis. Early recognition and a multidisciplinary approach involving nephrology and ophthalmology are essential to prevent irreversible renal and ocular damage.
Abdulelah Alshaiban
wiley   +1 more source

Blocking C5L2 decreased C5a-primed neutrophils for ANCA-induced degranulation.

open access: yes, 2013
ANCA-induced neutrophil degranulation was determined by measuring the lactoferrin concentrations in the supernatant. Blocking C5L2 reduced ANCA-induced lactoferrin release.
Jun Yuan (356273)   +4 more
core   +1 more source

Neutrophils: Heterogeneity, Biology, Diseases, and Therapeutic Strategies

open access: yesMedComm, Volume 7, Issue 11, November 2026.
Neutrophils exhibit remarkable functional plasticity and play dual roles in tissue protection and disease progression. This review summarizes their key biological functions and highlights the shift from conventional broad‐spectrum interventions to neutrophil‐based drug delivery systems.
Yibing Zhang   +4 more
wiley   +1 more source

MPO-C-ANCA-associated necrotising and crescentic glomerulonephritis

open access: yes, 2017
The patterns of ANCA staining usually relate closely to antibodies against myeloperoxidase and proteinase-3. C-ANCA is mainly antibodies to proteinase-3 and P-ANCA is antibodies to myeloperoxidase.
Abhilash Koratala   +3 more
core   +1 more source

Comparison of Interstitial Lung Disease Between Antineutrophil Cytoplasmic Antibodies Positive and Negative Patients: A Retrospective Cohort Study

open access: yesACR Open Rheumatology
Objective Positive antineutrophil cytoplasmic antibodies (ANCAs) may occur in the setting of interstitial lung disease (ILD), with or without ANCA‐associated vasculitis (AAV). We aim to compare the characteristics and clinical course of patients with ILD
Hao Cheng Shen   +7 more
doaj   +1 more source

PSC‐DM: A Validated Clinical Diagnostic Model for Distinguishing Primary From Secondary Sclerosing Cholangitis

open access: yesLiver International, Volume 46, Issue 11, November 2026.
ABSTRACT Background and Aims Primary sclerosing cholangitis (PSC) is a rare, progressive cholangiopathy for which diagnosis remains challenging because of the absence of disease‐specific markers and the presence of secondary causes of sclerosing cholangitis (SSC) that closely mimic its clinical presentation. Diagnostic uncertainty can delay appropriate
Miki Scaravaglio   +20 more
wiley   +1 more source

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