Results 51 to 60 of about 11,236,914 (284)

One origin for metallo-β-lactamase activity, or two? An investigation assessing a diverse set of reconstructed ancestral sequences based on a sample of phylogenetic trees [PDF]

, 2014
This work was supported by BBSRC (grant BB/F016778/1)Bacteria use metallo-β-lactamase enzymes to hydrolyse lactam rings found in many antibiotics, rendering them ineffective.
Barker, Daniel, Rosanna G. Alderson, John B. O. Mitchell, Daniel Barker, Alderson, Rosanna Grace, Alderson, Rosanna G, Mitchell, John B O, Mitchell, John B. O.   +7 more
core   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Puesta en valor de la alfarería ancestral – caso de estudio Museo Malta Huasi [PDF]

, 2023
La alfarería ancestral emerge como un tesoro tangible y arraigado en el tiempo. En esta búsqueda por rescatar y preservar el legado de la alfarería tiene como objetivo revalorizar los utensilios de barro del museo Malta Huasi a través de la ...
Pistala Yamá, Leidy Yohana
core   +1 more source

A comparative analysis of pollinator type and pollen ornamentation in the Araceae and the Arecaceae, two unrelated families of the monocots

BMC Research Notes, 2009
Background The high diversity of ornamentation type in pollen grains of angiosperms has often been suggested to be linked to diversity in pollination systems.
Anstett Marie-Charlotte, Baker William J, Sannier Julie, Nadot Sophie   +3 more
doaj   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Evaluation of Ancestral Sequence Reconstruction Methods to Infer Nonstationary Patterns of Nucleotide Substitution [PDF]

Genetics, 2015
AbstractInference of gene sequences in ancestral species has been widely used to test hypotheses concerning the process of molecular sequence evolution. However, the approach may produce spurious results, mainly because using the single best reconstruction while ignoring the suboptimal ones creates systematic biases.
Tomotaka, Matsumoto, Hiroshi, Akashi, Ziheng, Yang   +2 more
openaire   +2 more sources

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

A New Method for Integrating Ecological Niche Modeling with Phylogenetics to Estimate Ancestral Distributions

Systematic Biology, 2021
Abstract Ancestral range estimation and projection of niche models into the past have both become common in evolutionary studies where the ancient distributions of organisms are in question. However, these methods are hampered by complementary hurdles: discrete characterization of areas in ancestral range estimation can be overly ...
Wilson X, Guillory, Jason L, Brown
openaire   +2 more sources

Intercultural Education from Ancestral Logic: Application of the Ayni Method Multi-Neutrosophic to Strengthen Mixed Methodology in the Waorani Community [PDF]

Neutrosophic Sets and Systems
Research aimed at determining the Ayni method Multi -Neutrosophic by which a successful blended learning experience enhances multicultural education respecting Ancestral Logic of the Waoranis to create a hybridization of Ancestral Logic and institutional
Johanna Estefanía Calle Imbaquingo, Karen Milagros Díaz Salambay, Jordy Alexis Vargas Yumbo, Kevin Christopher Carrasco Azogue   +3 more
doaj   +1 more source

p190A/ARHGAP35 and p190B/ARHGAP5 proteins in endometrial cancer: a novel cancer‐relevant paralog interplay

Molecular Oncology, EarlyView.
This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault, Capucine Heraud, Mélissa Correia de Oliveira, Véronique Neaud, Valérie Valesco, Valérie Prouzet‐Mauleon, Béatrice Turcq, Jean‐William Dupuy, Anne‐Aurélie Raymond, Sabrina Croce, Frédéric Saltel, Valérie Lagrée, Violaine Moreau   +12 more
wiley   +1 more source