Results 141 to 150 of about 144,883 (257)

Engineered Microvascular Model of the Blood–Brain–Tumor Barrier Reveals Endothelial Remodeling in Diffuse Midline Glioma

Advanced Healthcare Materials, EarlyView.
We developed a patient‐derived, functional microfluidic model of the diffuse midline glioma (DMG) blood–brain–tumor barrier (BBTB) comprised of endothelial cells, astrocytes, pericytes, and tumor cells. The system forms perfusable microvasculature, reveals the BBTB retains vascular integrity, identifies DMG‐specific transcriptomic changes distinct from
Kimberly R. Bennett, Yann S. Vanrobaeys, Tessy Teboh, Zakiya Smith, Anderson Scott, Cynthia Hajal, Paula T. Hammond, Joelle P. Straehla   +7 more
wiley   +1 more source

Influence of Cardiometabolic and Alzheimer Disease Genetics on Cognitive-Related Outcomes in a Diverse Population. [PDF]

Neurology
Kim D, McInerney K, Dagli C, Armstrong ND, Cushman M, Bennett A, Blue EE, Sofer T, Sawyer RP, Yuan Y, Crowe M, Judd SE, Olson NC, Irvin MR, Raffield LM.   +14 more
europepmc   +1 more source

Patterned ELR‐Gelatin Hydrogels Enable Rapid Endothelial Monolayer Formation via Bioactive Matrix Chemistry and Surface Topography

Advanced Healthcare Materials, EarlyView.
Micro‐ and nano‐patterned elastin‐like recombinamer (ELR) hydrogels integrate bioactive matrix chemistry with defined surface topography. The combined cues promote rapid endothelial cell capture, alignment, and monolayer formation on soft substrates.
Jagoda Litowczenko, Yannick Richter, Martyna Michalska, Piotr Paczos, Karine Tadevosyan, Daniel Uribe, Jose Carlos Rodriguez‐Cabello, Ioannis Papakonstantinou, Angel Raya   +8 more
wiley   +1 more source

Circulating proteomic landscape of lung function. [PDF]

Eur Respir J
Lee M, Austin TR, Lee Y, Edris A, Axelsson GT, Thareja G, Chen J, Bartz TM, Gudmundsdottir V, House JS, Ruggles KV, Li L, Belkadi A, Qatar Genome Program Research Consortium, Chen Z, Jennings LL, Suhre K, Motsinger-Reif AA, Tobin MD, Gudnason V, Walters RG, Psaty BM, Gharib SA, Yu B, London SJ.   +24 more
europepmc   +1 more source

Cellularized Skin Substitute Bioengineering for Regenerative Medicine: Cell Sources, Culture Strategies, and Transition Toward Defined, Xeno‐Free Culture Systems

Advanced Healthcare Materials, EarlyView.
Advances in cell sources, bioengineering, and manufacturing are reshaping the design of skin substitutes. This review highlights emerging strategies driving skin tissue engineering and discusses their potential to enable safer, reproducible, and clinically accessible skin substitutes for regenerative medicine.
Gilles Lemaître, Marina Trouillas, Tatiana Vinasco‐Sandoval, Cécile Giordano, Alexandre G. Lellouch, Walid Rachidi, Jean‐Jacques Lataillade, Nicolas O. Fortunel   +7 more
wiley   +1 more source

Identifying the contributions of progenitor Malus species to cultivated apple (M. domestica) using 20K SNP array data. [PDF]

BMC Genomics
Howard NP, Vanderzande S, Khan G, Luby JJ, Volk GM, Albach DC, Peace C.   +6 more
europepmc   +1 more source

Anisotropic Masked Mycobacterium Potentiates Amplified Antitumor Trained Immunity via Spleen Targeting and Myelopoiesis Conversion

Advanced Materials, EarlyView.
An engineered Trojan Mycobacterium, developed via a “peeling‐off and masking‐up” strategy, functions as a powerful splenic myelopoiesis converter. This spleen‐targeted nanomedicine induces trained immunity to reprogram immunosuppressive myeloid reservoirs into antitumoral effectors.
Jin‐Ho Choi, Sang Nam Lee, Jang Hun Heo, Soyoung Park, Sei Hyun Park, Yong Taik Lim   +5 more
wiley   +1 more source

Ancestry

, 2020
  +4 more sources

Faroese whole genomes provide insight into ancestry and recent selection. [PDF]

Elife
Hamid I, Mortensen Ó, Refoyo-Martínez A, Lydersen LN, Emde AK, Hendershott M, Apol KD, Andorsdóttir G, Meisner J, Wasik KA, Racimo F, Castel SE, Gregersen NO.   +12 more
europepmc   +1 more source

Engineering Pluripotent Stem Cells‐Derived Inner Ear Organoids With Enhanced Maturation and Reproducibility by Micro‐Topographical Cues

Advanced Materials, EarlyView.
Micro‐topographical cues applied through temporally controlled microscale confinement improve the reproducibility, spatial organization, and neurosensory‐associated features of pluripotent stem cell‐derived inner ear organoids. Integration with a vascularized organoid platform further enables controlled investigation of vascular‐epithelial interactions
Harshita Sharma, Jungeun Lim, Woochan Kim, Yeon Ju Kim, Dream Kim, Shinyull Lee, Chaeyeon Park, Stephen Rhee, Shruthy Kuttapan, Jungho Ha, Sang Wook Park, Kyunghoon Kim, Noo Li Jeon, Sunho Park, Yun‐Hoon Choung, Jangho Kim   +15 more
wiley   +1 more source